scholarly journals Synergism of Hydrochlorothiazide and Nifedipine on Blood Pressure Variability Reduction and Organ Protection in Spontaneously Hypertensive Rats

2008 ◽  
Vol 31 (4) ◽  
pp. 685-691 ◽  
Author(s):  
He-Hui Xie ◽  
Xiao-Fei Zhang ◽  
Yuan-Yuan Chen ◽  
Fu-Ming Shen ◽  
Ding-Feng Su
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Organ Protection ◽  
Spontaneously Hypertensive

Effects of low-dose ketanserin on blood pressure variability, baroreflex sensitivity and end-organ damage in spontaneously hypertensive rats

2005 ◽  
Vol 108 (6) ◽  
pp. 547-552 ◽  
Author(s):  
He-Hui XIE ◽  
Fu-Ming SHEN ◽  
Yong-Bing CAO ◽  
Hui-Lin LI ◽  
Ding-Feng SU
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Spontaneously Hypertensive Rats ◽  
Baroreflex Sensitivity ◽  
Low Dose ◽  
Organ Damage ◽  
Left Ventricular ◽  
Hypertensive Rats ◽  
Organ Protection ◽  
Spontaneously Hypertensive

The present study was designed to investigate the effects of low-dose ketanserin on BPV (blood pressure variability), BRS (baroreflex sensitivity) and organ damage in SHR (spontaneously hypertensive rats). Ketanserin was mixed in rat chow at an estimated dose of 0.1 mg·kg−1 of body weight·day−1. SHR were treated for 4 months. BP (blood pressure) was then recorded continuously for 24 h in a conscious state. After determination of BRS, rats were killed for organ damage evaluation. It was found that long-term treatment with low-dose ketanserin did not lower BP levels, but significantly decreased BPV, enhanced BRS and reduced organ damage in SHR. Multiple regression analysis showed that the decrease in left ventricular hypertrophy was most closely correlated (or associated) with the increase in BRS, whereas the decrease in aortic hypertrophy was most closely associated with the decrease in diastolic BPV and the amelioration in renal lesion, with the increase in BRS and the decrease in diastolic BPV. In conclusion, low-dose ketanserin produces organ protection independently of its BP-lowering action in SHR, and this organ protection was importantly attributable to the enhancement of BRS and decrease in BPV.

Effects of Clonidine and Flesionoxan on Blood Pressure Variability in Conscious Spontaneously Hypertensive Rats

1997 ◽  
Vol 30 (2) ◽  
pp. 241-244 ◽  
Author(s):  
Kamel Chaouche-Teyara ◽  
Patrick Lacolley ◽  
Pascal Challande ◽  
Berthe Fournier ◽  
Stéphane Laurent ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Reduction of blood pressure variability by combination therapy in spontaneously hypertensive rats

2007 ◽  
Vol 25 (11) ◽  
pp. 2334-2344 ◽  
Author(s):  
He-Hui Xie ◽  
Fu-Ming Shen ◽  
Li-Ping Xu ◽  
Ping Han ◽  
Chao-Yu Miao ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Combination Therapy ◽  
Blood Pressure Variability ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive
Sign in / Sign up

Export Citation Format

Share Document