scholarly journals Hemodynamic Characterization of Recombinant Inbred Strains: Twenty Years Later

2008 ◽  
Vol 31 (8) ◽  
pp. 1659-1668 ◽  
Author(s):  
Jaroslav KUNES ◽  
Zdenka DOBESOVA ◽  
Alena MUSILOVA ◽  
Vaclav ZIDEK ◽  
Jaroslav VORLICEK ◽  
...  
Keyword(s):  
Recombinant Inbred ◽  
Inbred Strains ◽  
Recombinant Inbred Strains

GENETIC ANALYSIS OF PLASMA CORTICOSTERONE LEVELS IN TWO INBRED STRAINS OF MICE

1972 ◽  
Vol 55 (2) ◽  
pp. 415-420 ◽  
Author(s):  
B. E. ELEFTHERIOU ◽  
D. W. BAILEY
Keyword(s):  
Genetic Analysis ◽  
Recombinant Inbred ◽  
Epistatic Interaction ◽  
Genetic Model ◽  
Inbred Strains ◽  
Plasma Corticosterone ◽  
Experimental Results ◽  
Recombinant Inbred Strains ◽  
Inbred Strains Of Mice

SUMMARY Plasma corticosterone levels were determined fluorometrically in mice of two unrelated highly inbred strains, C57BL/6By and BALB/cBy, and in seven of their derived recombinant-inbred strains as well as their F1 hybrid and backcross generations necessary to arrive at a genetic model for plasma corticosterone levels. It was concluded that the simplest genetic model, and one which fits the experimental results, was one which assumed that plasma corticosterone levels are controlled genetically by two loci with the epistatic interaction indicating dependency of pathways of action for the two genes.

scholarly journals Genetic Contribution to Initial and Progressive Alcohol Intake Among Recombinant Inbred Strains of Mice

2018 ◽  
Vol 9 ◽  
Author(s):  
Megan K. Mulligan ◽  
Wenyuan Zhao ◽  
Morgan Dickerson ◽  
Danny Arends ◽  
Pjotr Prins ◽  
...  
Keyword(s):  
Recombinant Inbred ◽  
Alcohol Intake ◽  
Inbred Strains ◽  
Recombinant Inbred Strains ◽  
Genetic Contribution ◽  
Inbred Strains Of Mice

Strain distribution pattern in AXB and BXA recombinant inbred strains for loci on murine Chromosomes 10, 13, 17, and 18

1993 ◽  
Vol 4 (3) ◽  
pp. 148-152 ◽  
Author(s):  
Jian-Long Mu ◽  
J�rgen K. Naggert ◽  
Patsy M. Nishina ◽  
Yin-Chai Cheah ◽  
Beverly Paigen
Keyword(s):  
Distribution Pattern ◽  
Recombinant Inbred ◽  
Strain Distribution ◽  
Inbred Strains ◽  
Recombinant Inbred Strains ◽  
Strain Distribution Pattern

scholarly journals Rheumatoid factors in 129XB recombinant inbred strains. Igh-1-linked control of allotypic and isotypic specificities.

1984 ◽  
Vol 159 (2) ◽  
pp. 355-364 ◽  
Author(s):  
J Van Snick ◽  
J P Coutelier ◽  
E Van Roost ◽  
J L Guénet
Keyword(s):  
Recombinant Inbred ◽  
Inbred Strains ◽  
Recombinant Inbred Strains ◽  
Rheumatoid Factors ◽  
Additional Form

To examine the role of autologous IgG in the induction of murine rheumatoid factors (RF) we have analyzed the allotypic specificity of anti-IgG2a RF in recombinant inbred strains derived from 129/Sv (Igh-1a) and C57BL/6 (Igh-1b) mice. In five of six Igh-1a strains, anti-IgG2a RF reacted with IgG2aa but failed to react with IgG2ab. In contrast, isotype-specific RF, which reacted equally well with a and b allotypes of IgG2a, represented the major RF species in one Igh-1a and all five Igh-1b strains tested. An additional form of RF specific for IgG2ab and not reactive with IgG2aa was detected in one Igh-1b strain. RF specific for a give allotype was thus only found in the presence of that allotype, which strongly suggests the involvement of autologous IgG in the induction of mouse RF synthesis. The specificity of RF was apparently further controlled by genes linked to but different from the Igh-C locus, as indicated by the absence of IgG2aa-specific RF in one of the 6 Igh-1a strains tested. Because this strain, 129XBG, has been shown to express idiotypic markers characteristic of Igh-1b mice, it is likely that the genes, which in the presence of a given allotype induce the production of isotype rather than allotype-specific RF, are identical to those that control the expression of idiotypes. Evidence was also obtained to indicate that Igh-1-linked genes influence the isotypic specificity and the isotype of RF itself: IgA anti-IgG2a predominated in Igh-1a strains and IgM anti-IgG1 in Igh-1b strains. Interestingly enough, total IgA and IgG2a levels also were higher in Igh-1a than in Igh-1b strains.

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