scholarly journals Antiproliferative Action of an Angiotensin I-Converting Enzyme Inhibitory Peptide, Val-Tyr, via an L-Type Ca2+ Channel Inhibition in Cultured Vascular Smooth Muscle Cells

2005 ◽  
Vol 28 (6) ◽  
pp. 545-552 ◽  
Author(s):  
Toshiro MATSUI ◽  
Takao UENO ◽  
Mitsuru TANAKA ◽  
Hiromi OKA ◽  
Takahisa MIYAMOTO ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Inhibitory Peptide ◽  
Angiotensin I Converting Enzyme ◽  
Channel Inhibition

Endothelium-independent conversion of angiotensin I by vascular smooth muscle cells

2001 ◽  
Vol 303 (2) ◽  
pp. 227-234 ◽  
Author(s):  
Florence Coulet ◽  
Walter Gonzalez ◽  
Christophe Boixel ◽  
Olivier Meilhac ◽  
Maria E. Pueyo ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Angiotensin I

Influence of atorvastatin on angiotensin I metabolism in rat vascular smooth muscle cells

2013 ◽  
Vol 65 ◽  
pp. 47 ◽  
Author(s):  
Anna Gębska ◽  
Maciej Suski ◽  
Rafał Olszanecki ◽  
Aneta Stachowicz ◽  
Barbara Lorkowska-Zawicka ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Angiotensin I

scholarly journals The Serpin Proteinase Inhibitor 9 Is an Endogenous Inhibitor of Interleukin 1β–Converting Enzyme (Caspase-1) Activity in Human Vascular Smooth Muscle Cells

2000 ◽  
Vol 191 (9) ◽  
pp. 1535-1544 ◽  
Author(s):  
James L. Young ◽  
Galina K. Sukhova ◽  
Don Foster ◽  
Walter Kisiel ◽  
Peter Libby ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Inhibitory Activity ◽  
Proteinase Inhibitor ◽  
Muscle Cells ◽  
Converting Enzyme ◽  
Endogenous Inhibitor ◽  
Caspase 1

Interleukin-1β–converting enzyme (ICE, caspase-1) regulates key steps in inflammation and immunity, by activating the proinflammatory cytokines interleukin (IL-)1β and IL-18, or mediating apoptotic processes. We recently provided evidence for the regulation of caspase-1 activity via an endogenous inhibitor expressed by human vascular smooth muscle cells (SMCs) (Schönbeck, U., M. Herzberg, A. Petersen, C. Wohlenberg, J. Gerdes, H.-D. Flad, and H. Loppnow. 1997. J. Exp. Med. 185:1287–1294). However, the molecular identity of this endogenous inhibitor remained undefined. We report here that the serine proteinase inhibitor (serpin) PI-9 accounts for the endogenous caspase-1 inhibitory activity in human SMCs and prevents processing of the enzyme's natural substrates, IL-1β and IL-18 precursor. Treatment of SMC lysates with anti–PI-9 antibody abrogated the caspase-1 inhibitory activity and coprecipitated the enzyme, demonstrating protein–protein interaction. Furthermore, PI-9 antisense oligonucleotides coordinately reduced PI-9 expression and promoted IL-1β release. Since SMCs comprise the majority of cells in the vascular wall, and because IL-1 is implicated in atherogenesis, we tested the biological validity of our in vitro findings within human atheroma in situ. The unaffected arterial wall contains abundant and homogeneously distributed PI-9. In human atherosclerotic lesions, however, PI-9 expression correlated inversely with immunoreactive IL-1β, supporting a potential role of the endogenous caspase-1 inhibitor in this chronic inflammatory disease. Thus, our results provide new insights into the regulation of this enzyme involved in immune and inflammatory processes of chronic inflammatory diseases, and point to an endogenous antiinflammatory action of PI-9, dysregulated in a prevalent human disease.

scholarly journals A REVIEW ON ENDOTHELINS: AN UPDATE

2018 ◽  
Vol 11 (4) ◽  
pp. 38
Author(s):  
Anitha Nandagopal ◽  
Mubeen Unnisa Shamsia
Keyword(s):  
Endothelial Cells ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Converting Enzyme ◽  
Endothelin Converting Enzyme ◽  
Eta Receptor ◽  
Potent Vasoconstrictor

 Endothelin (ET) is the most potent vasoconstrictor. It is secreted by the endothelial cells. At low concentration, it acts as an agonist for endothelium-derived relaxing factors and thereby causes vasodilatation, and at higher concentration it acts as a potent vasoconstrictor. It is synthesized by proteolytic cleavage of preproendothelin to proendothelin by the action of metallopeptidases and chymase, which is further cleaved into mature form of ET by endothelin converting enzyme. There are four isoforms of ET, namely, ET-1, ET-2, ET-3, and ET-4. ET acts on 2 types of receptors. Binding of ET-1 to ETA receptor at the vascular smooth muscle cells induces vasoconstriction. It also produces vasoconstriction by acting on the ETB2 receptor of vascular smooth muscle cells but promotes vasodilatation at ETB1 receptor present on the endothelial cell.

scholarly journals Influence of atorvastatin on angiotensin I metabolism in resting and TNF-α -activated rat vascular smooth muscle cells

2013 ◽  
Vol 15 (4) ◽  
pp. 378-383 ◽  
Author(s):  
Maciej Suski ◽  
Anna Gębska ◽  
Rafal Olszanecki ◽  
Aneta Stachowicz ◽  
Danuta Uracz ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Angiotensin I ◽  
Tnf Α
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