scholarly journals Angiotensin II-Induced Ventricular Hypertrophy and Extracellular Signal-Regulated Kinase Activation Are Suppressed in Mice Overexpressing Brain Natriuretic Peptide in Circulation

2003 ◽  
Vol 26 (10) ◽  
pp. 847-853 ◽  
Author(s):  
Nobuki TAKAHASHI ◽  
Yoshihiko SAITO ◽  
Koichiro KUWAHARA ◽  
Masaki HARADA ◽  
Ichiro KISHIMOTO ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Ventricular Hypertrophy ◽  
Kinase Activation ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

scholarly journals Interleukin-10 inhibits lipopolysaccharide-induced survival and extracellular signal-regulated kinase activation in human neutrophils

2005 ◽  
Vol 35 (9) ◽  
pp. 2728-2737 ◽  
Author(s):  
Carol Ward ◽  
Joanna Murray ◽  
April Clugston ◽  
Ian Dransfield ◽  
Christopher Haslett ◽  
...  
Keyword(s):  
Interleukin 10 ◽  
Human Neutrophils ◽  
Kinase Activation ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

scholarly journals Renin and prorenin have no direct effect on aldosterone synthesis in the human adrenocortical cell lines H295R and HAC15

2012 ◽  
Vol 13 (3) ◽  
pp. 360-366 ◽  
Author(s):  
Pieter M Jansen ◽  
Johannes Hofland ◽  
Anton H van den Meiracker ◽  
Frank H de Jong ◽  
AH Jan Danser
Keyword(s):  
Angiotensin Ii ◽  
Cell Lines ◽  
Renin Angiotensin System ◽  
Adrenocortical Cell ◽  
Transgenic Rats ◽  
Angiotensin System ◽  
Extracellular Signal Regulated Kinase ◽  
Erk Phosphorylation ◽  
Extracellular Signal ◽  
Aldosterone Production

Introduction: Transgenic rats expressing the human (pro)renin receptor (h(P)RR) have elevated plasma aldosterone levels despite unaltered levels, in plasma and adrenal, of renin and angiotensin II. Materials and methods: To investigate whether renin/prorenin–(P)RR interaction underlies these elevated aldosterone levels, the effect of (pro)renin on steroidogenesis was compared with that of angiotensin II in two (P)RR-expressing human adrenocortical cell lines, H295R and HAC15. Angiotensin II rapidly induced extracellular signal-regulated kinase (ERK) phosphorylation and increased the expression of STAR, CYP21A2, CYP11B2, and CYP17A1 at 6 and 24 hours, whereas the expression of CYP11A1 and HSD3B2 remained unaltered. Incubation with renin or prorenin at nanomolar concentrations had no effect on the expression of any of the steroidogenic enzymes tested, nor resulted in ERK phosphorylation. Angiotensin II, but not renin or prorenin, induced aldosterone production. Conclusion: Although the (P)RR is present in adrenocortical cells, renin and prorenin do not elicit ERK phosphorylation nor directly affect steroid production via this receptor at nanomolar concentrations. Thus, direct (pro)renin–(P)RR interaction is unlikely to contribute to the elevated aldosterone levels in human (P)RR transgenic rats. This conclusion also implies that the aldosterone rise that often occurs during prolonged renin–angiotensin system blockade is rather due to the angiotensin II ‘escape’ during such blockade.

scholarly journals Cue-Elicited Reward-Seeking Requires Extracellular Signal-Regulated Kinase Activation in the Nucleus Accumbens

2008 ◽  
Vol 28 (6) ◽  
pp. 1434-1443 ◽  
Author(s):  
M. W. Shiflett ◽  
R. P. Martini ◽  
J. C. Mauna ◽  
R. L. Foster ◽  
E. Peet ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Kinase Activation ◽  
Extracellular Signal Regulated Kinase ◽  
Reward Seeking ◽  
Extracellular Signal

Cyclooxygenase-2 Up-Regulates Ataxia Telangiectasia and Rad3 Related through Extracellular Signal-Regulated Kinase Activation

2009 ◽  
Vol 7 (7) ◽  
pp. 1158-1168 ◽  
Author(s):  
Young Mee Kim ◽  
Eun Jung Lee ◽  
Soo-Yeon Park ◽  
Kwan Ho Cho ◽  
Joo Young Kim ◽  
...  
Keyword(s):  
Ataxia Telangiectasia ◽  
Cyclooxygenase 2 ◽  
Kinase Activation ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal
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