scholarly journals Differential Induction of Protein Kinase C Isoforms at the Cardiac Hypertrophy Stage and Congestive Heart Failure Stage in Dahl Salt-Sensitive Rats

2003 ◽  
Vol 26 (5) ◽  
pp. 421-426 ◽  
Author(s):  
Yuichi KOIDE ◽  
Kouichi TAMURA ◽  
Atsushi SUZUKI ◽  
Kouichi KITAMURA ◽  
Keiko YOKOYAMA ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cardiac Hypertrophy ◽  
Kinase C ◽  
Differential Induction ◽  
Protein Kinase C Isoforms

Expression of protein kinase C isoforms in cardiac hypertrophy and heart failure due to volume overload

2006 ◽  
Vol 84 (2) ◽  
pp. 227-238 ◽  
Author(s):  
Emmanuelle Sentex ◽  
Xi Wang ◽  
Xueliang Liu ◽  
Anton Lukas ◽  
Naranjan S. Dhalla
Keyword(s):  
Heart Failure ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cardiac Hypertrophy ◽  
Volume Overload ◽  
Aortocaval Shunt ◽  
Kinase C ◽  
Pkc Β ◽  
Pkc Ζ ◽  
Protein Kinase C Isoforms

The present study determined whether changes in the activity and isoforms of protein kinase C (PKC) are associated with cardiac hypertrophy and heart failure owing to volume overload induced by aortocaval shunt (AVS) in rats. A significant increase in Ca2+-dependent and Ca2+-independent PKC activities in the homogenate and particulate fractions, unlike the cystolic fraction, of the hypertrophied left ventricle (LV) were evident at 2 and 4 weeks after inducing the AVS. This increase coincided with increases in PKC-α and PKC-ζ contents at 2 week and increases in PKC-α, PKC-β1, PKC-β2, and PKC-ζ contents at 4 weeks in the hypertrophied LV. By 8 and 16 weeks of AVS, PKC activity and content were unchanged in the failing LV. On the other hand, no increase in the PKC activity or isoform content in the hypertrophied right ventricle (RV) was observed during the 16 weeks of AVS. The content of Gαq was increased in the LV at 2 weeks but then decreased at 16 weeks, whereas Gαq content was increased in RV at 2 and 4 weeks. Our data suggest that an increase in PKC isoform content neither plays an important role during the development of cardiac hypertrophy nor participates in the phase leading to heart failure owing to volume overload.

Changes of protein kinase C in congestive heart failure in rats

2001 ◽  
Vol 33 (6) ◽  
pp. A128 ◽  
Author(s):  
Jingwei Wang ◽  
Emmanuelle Sentex ◽  
Naranjan S. Dhalla
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Kinase C

scholarly journals Responses of Cardiac Protein Kinase C Isoforms to Distinct Pathological Stimuli Are Differentially Regulated

1999 ◽  
Vol 85 (3) ◽  
pp. 264-271 ◽  
Author(s):  
Yasuchika Takeishi ◽  
Thunder Jalili ◽  
Nancy A. Ball ◽  
Richard A. Walsh
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Kinase C ◽  
Protein Kinase C Isoforms

Glucocorticoid-induced insulin resistance associates with activation of protein kinase C isoforms

2001 ◽  
Vol 13 (3) ◽  
pp. 169-175 ◽  
Author(s):  
Kazuo Kajita ◽  
Tatsuo Ishizuka ◽  
Atsushi Miura ◽  
Yoshinori Kanoh ◽  
Masayoshi Ishizawa ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Kinase C ◽  
Protein Kinase C Isoforms

Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice

2005 ◽  
Vol 1060 (1-2) ◽  
pp. 62-72 ◽  
Author(s):  
Junfa Li ◽  
Chenchen Niu ◽  
Song Han ◽  
Pengyu Zu ◽  
Hua Li ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Hypoxic Preconditioning ◽  
Kinase C ◽  
Protein Kinase C Isoforms
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