scholarly journals Cyclooxygenase-2 Inhibitors Attenuate Increased Blood Pressure in Renovascular Hypertensive Models, but Not in Deoxycorticosterone-Salt Hypertension.

2002 ◽  
Vol 25 (6) ◽  
pp. 927-938 ◽  
Author(s):  
Toshiaki OKUMURA ◽  
Izumi HAYASHI ◽  
Tomoaki IKEZAWA ◽  
Mariko YAMANAKA ◽  
Tesshu TAKATA ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cyclooxygenase 2 ◽  
Salt Hypertension ◽  
Cyclooxygenase 2 Inhibitors

Effect of Cyclooxygenase-2 Inhibitors on Blood Pressure

2003 ◽  
Vol 37 (3) ◽  
pp. 442-446 ◽  
Author(s):  
Deanna L Johnson ◽  
Tina M Hisel ◽  
Beth Bryles Phillips
Keyword(s):  
Blood Pressure ◽  
Cyclooxygenase 2 ◽  
Data Sources ◽  
Selective Inhibitors ◽  
Data Synthesis ◽  
Hypertensive Patients ◽  
Search Terms ◽  
Clinical Literature ◽  
Cox 2 ◽  
Cyclooxygenase 2 Inhibitors

OBJECTIVE: To evaluate the effect of cyclooxygenase-2 selective inhibitors (CSIs) on blood pressure. DATA SOURCES: Clinical literature accessed through MEDLINE (1966–May 2002). Key search terms included COX-2 selective inhibitors; anti-inflammatory agents, nonsteroidal; celecoxib; rofecoxib; and hypertension. DATA SYNTHESIS: Data from prospective studies on the effects of CSIs on blood pressure are conflicting. Several studies have reported increased blood pressure as an adverse effect of CSIs. CONCLUSIONS: Additional studies are needed to evaluate the effects of CSIs on blood pressure. CSIs should be used with caution in hypertensive patients and blood pressure monitored closely if a CSI is indicated.

Chemoprevention of Cancers in Gastrointestinal Tract with Cyclooxygenase 2 Inhibitors

2012 ◽  
Vol 19 (1) ◽  
pp. 115-125
Author(s):  
Rui Wang ◽  
Linjie Guo ◽  
Pu Wang ◽  
Wenjuan Yang ◽  
Yaoyao Lu ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Cyclooxygenase 2 ◽  
Cyclooxygenase 2 Inhibitors
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