scholarly journals Epidemiological Evidence of the Association between Dietary Protein Intake and Blood Pressure: A Meta-Analysis of Published Data.

2002 ◽  
Vol 25 (5) ◽  
pp. 689-695 ◽  
Author(s):  
Longjian LIU ◽  
Katsumi IKEDA ◽  
Dennis H SULLIVAN ◽  
Wenhua LING ◽  
Yukio YAMORI
Keyword(s):  
Blood Pressure ◽  
Dietary Protein ◽  
Protein Intake ◽  
Meta Analysis ◽  
Published Data ◽  
Dietary Protein Intake ◽  
Epidemiological Evidence

Abstract 023: The Effect of Dietary Protein on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Casey M Rebholz ◽  
Eleanor E Friedman ◽  
Lindsey J Powers ◽  
Whitney D Arroyave ◽  
Jiang He ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Randomized Controlled Trials ◽  
Diastolic Blood Pressure ◽  
Dietary Protein ◽  
Protein Intake ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Dietary Protein Intake ◽  
Randomized Controlled

Lifestyle modifications such as weight loss, increasing physical activity, and reducing alcohol consumption and salt intake have been consistently shown to decrease blood pressure. Less well understood is whether increased dietary protein intake may also reduce blood pressure and the risk of hypertension. We conducted a meta-analysis of randomized controlled trials to assess the hypothesis that increased dietary protein intake decreases systolic and diastolic blood pressure in adults. MEDLINE, EMBASE, Cochrane Library, Web of Science, a registry of soy research trials, bibliography review, and expert consultation were the sources of English and non-English articles published before April 2011. Search terms included randomized controlled trial, blood pressure, dietary proteins, dietary supplements, casein, soy, and meat. Forty randomized controlled trials including 3,277 participants in which amount or source of protein was the only difference between the intervention and comparison groups and that examined blood pressure were included. Using a standardized protocol and data extraction form, two investigators independently abstracted data on study design, participant characteristics, intervention, and treatment outcomes. Net effects of protein on blood pressure were pooled across trials and weighted by the inverse of the variance using random-effects models. Compared to carbohydrate, dietary protein was associated with significant decreases in mean systolic and diastolic blood pressure (95% confidence intervals) of -1.75 (-2.31, -1.19) and -1.16 (-1.60, -0.72) mmHg, respectively (all P<0.001). Blood pressure lowering effects of both vegetable and animal sources of protein were observed with significant decreases of -2.22 (-3.18, -1.26) and -2.54 (-3.55, -1.53) mmHg for systolic blood pressure, respectively (all P<0.001), and -1.25 (-2.12, -0.39) and -0.95 (-1.72, -0.19) mmHg for diastolic blood pressure, respectively (P=0.005 and 0.01, respectively). Blood pressure reduction was not significantly different when vegetable protein was compared directly to animal protein. In conclusion, dietary protein intake reduces systolic and diastolic blood pressure in adults. Replacement of carbohydrate intake with protein intake, from either vegetable or animal sources, could be an important strategy for helping to curb the growing pandemic of hypertension and related cardiovascular disease morbidity and mortality. Future research is indicated to assess potential differential effects of protein on blood pressure according to hypertension status.

scholarly journals Dietary Protein Intake and Blood Pressure: A Meta-Analysis of Randomized Controlled Trials

2012 ◽  
Vol 176 (suppl_7) ◽  
pp. S27-S43 ◽  
Author(s):  
Casey M. Rebholz ◽  
Eleanor E. Friedman ◽  
Lindsey J. Powers ◽  
Whitney D. Arroyave ◽  
Jiang He ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Randomized Controlled Trials ◽  
Dietary Protein ◽  
Protein Intake ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Dietary Protein Intake ◽  
Randomized Controlled

scholarly journals The relationship between dietary protein intake and blood pressure: results from the PREMIER study

2008 ◽  
Vol 22 (11) ◽  
pp. 745-754 ◽  
Author(s):  
Y F Wang ◽  
WS Yancy Jr ◽  
D Yu ◽  
C Champagne ◽  
L J Appel ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake ◽  
The Relationship

scholarly journals Genetic Susceptibility, Dietary Protein Intake, and Changes of Blood Pressure

Hypertension ◽  
2019 ◽  
Vol 74 (6) ◽  
pp. 1460-1467 ◽  
Author(s):  
Dianjianyi Sun ◽  
Tao Zhou ◽  
Xiang Li ◽  
Yoriko Heianza ◽  
Zhaoxia Liang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Genetic Susceptibility ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake

scholarly journals Effects of protein intake on blood pressure, insulin sensitivity and blood lipids in children: a systematic review

2015 ◽  
Vol 113 (3) ◽  
pp. 383-402 ◽  
Author(s):  
Trudy Voortman ◽  
Anna Vitezova ◽  
Wichor M. Bramer ◽  
Charlotte L. Ars ◽  
Paula K. Bautista ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Insulin Sensitivity ◽  
Dietary Protein ◽  
Protein Intake ◽  
Blood Lipids ◽  
Healthy Children ◽  
Inverse Association ◽  
Dietary Protein Intake ◽  
Cross Sectional ◽  
Beneficial Effects

High protein intake in early childhood is associated with obesity, suggesting possible adverse effects on other cardiometabolic outcomes. However, studies in adults have suggested beneficial effects of protein intake on blood pressure (BP) and lipid profile. Whether dietary protein intake is associated with cardiovascular and metabolic health in children is unclear. Therefore, we aimed to systematically review the evidence on the associations of protein intake with BP, insulin sensitivity and blood lipids in children. We searched the databases Medline, Embase, Cochrane Central and PubMed for interventional and observational studies in healthy children up to the age of 18 years, in which associations of total, animal and/or vegetable protein intake with one or more of the following outcomes were reported: BP; measures of insulin sensitivity; cholesterol levels; or TAG levels. In the search, we identified 6636 abstracts, of which fifty-six studies met all selection criteria. In general, the quality of the included studies was low. Most studies were cross-sectional, and many did not control for potential confounders. No overall associations were observed between protein intake and insulin sensitivity or blood lipids. A few studies suggested an inverse association between dietary protein intake and BP, but evidence was inconclusive. Only four studies examined the effects of vegetable or animal protein intake, but with inconsistent results. In conclusion, the literature, to date provides insufficient evidence for effects of protein intake on BP, insulin sensitivity or blood lipids in children. Future studies could be improved by adequately adjusting for key confounders such as energy intake and obesity.

scholarly journals The association between dietary protein intake and esophageal cancer risk: a meta-analysis

2020 ◽  
Vol 40 (1) ◽  
Author(s):  
Fanjuan Kong ◽  
Erdong Geng ◽  
Juan Ning ◽  
Zhiyu Liu ◽  
Aihua Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Cancer Risk ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Dietary Protein ◽  
Protein Intake ◽  
Meta Analysis ◽  
Dietary Protein Intake

Abstract Several papers studied dietary protein intake as a potential influence factor for esophageal cancer, but their findings were inconsistent. Thus, this meta-analysis was performed to identify the effect of protein intake on esophageal cancer risk. Potential case–control studies or cohort studies from the databases of Embase, Web of Science and PubMed were searched. The strength of association was quantified by pooling odds ratio (OR) and 95% confidence interval (CI). In total, 11 articles involving 2537 cases and 11432 participants were included in this meta-analysis. As a result, dietary protein intake had non-significant association on esophageal cancer risk overall (pooled OR = 1.11, 95% CI = 0.88–1.40). Meanwhile, we obtained consistent results in the subgroups analyses by study design, protein type, geographic locations and number of cases. Interestingly, dietary protein intake could significantly increase the risk of esophageal squamous cell carcinoma (pooled OR = 1.29, 95% CI = 1.02–1.62), instead of other disease type. To sum up, dietary protein intake had no significant association with esophageal cancer risk in the overall analysis; but, protein intake may be associated with the risk of esophageal squamous cell carcinoma. While some limitations existed in the present paper, more studies with large sample size are warranted to further confirm this result.

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