scholarly journals Cross Talk between Angiotensin II Type 1 and Type 2 Receptors: Cellular Mechanism of Angiotensin Type 2 Receptor-Mediated Cell Growth Inhibition.

1999 ◽  
Vol 22 (2) ◽  
pp. 67-74 ◽  
Author(s):  
Masatsugu Horiuchi ◽  
Meiko Hamai ◽  
Tai-Xing Cui ◽  
Masaru Iwai ◽  
Yasuhiko Minokoshi
Keyword(s):  
Angiotensin Ii ◽  
Cell Growth ◽  
Growth Inhibition ◽  
Cross Talk ◽  
Cellular Mechanism ◽  
Cell Growth Inhibition ◽  
Angiotensin Type 2 Receptor ◽  
Angiotensin Type

scholarly journals Renal Angiotensin Type 2 Receptors Mediate Natriuresis Via Angiotensin III in the Angiotensin II Type 1 Receptor–Blocked Rat

Hypertension ◽  
2006 ◽  
Vol 47 (3) ◽  
pp. 537-544 ◽  
Author(s):  
Shetal H. Padia ◽  
Nancy L. Howell ◽  
Helmy M. Siragy ◽  
Robert M. Carey
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Iii ◽  
Angiotensin Type

1008 ANGIOTENSIN TYPE-2 RECEPTOR CONTRIBUTES TO REDUCED VASCULAR RESPONSE TO ANGIOTENSIN-II IN YOUNG RATS

2012 ◽  
Vol 30 ◽  
pp. e292
Author(s):  
Russell D. Brown ◽  
Rebecca Flower ◽  
Karen Moritz ◽  
Roger G Evans ◽  
Kate M. Denton
Keyword(s):  
Angiotensin Ii ◽  
Vascular Response ◽  
Young Rats ◽  
Angiotensin Type 2 Receptor ◽  
Angiotensin Type

scholarly journals Advances in the Renin-Angiotensin-Aldosterone System: Relevance to Diabetic Nephropathy

2008 ◽  
Vol 8 ◽  
pp. 434-445 ◽  
Author(s):  
Audrey Koitka ◽  
Christos Tikellis
Keyword(s):  
Diabetic Nephropathy ◽  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Renal Disease ◽  
Converting Enzyme ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
Angiotensin Type 2 Receptor

Hypertension is now recognized as a key contributory factor to the development and progression of kidney disease in both type 1 and type 2 diabetes. The renin angiotensin system (RAS) and its effector molecule angiotensin II, in particular, have a range of hemodynamic and nonhemodynamic effects that contribute not only to the development of hypertension, but also to renal disease. As a result, therapeutic inhibition of the RAS with angiotensin-converting enzyme inhibitors and/or selective angiotensin II type 1 receptor blockers has been proposed as a key strategy for reducing kidney damage beyond the expected effects one would observe with blood pressure reduction per se. Although the relationship between the RAS and the progression of diabetic renal disease has been known for many decades, recent advances have revealed a more complex paradigm with the discovery of a number of new components. Thus, further understanding of these new components of the renin angiotensin aldosterone system (RAAS), such as the angiotensin type 2 receptor subtype, angiotensin converting enzyme 2, and the recently cloned renin receptor, is likely to have therapeutic implications for disorders such as diabetic nephropathy, where interruption of the RAAS is widely used.

scholarly journals Pressor responsiveness to angiotensin II in female mice is enhanced with age: role of the angiotensin type 2 receptor

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Katrina M Mirabito ◽  
Lucinda M Hilliard ◽  
Geoffrey A Head ◽  
Robert E Widdop ◽  
Kate M Denton
Keyword(s):  
Angiotensin Ii ◽  
Female Mice ◽  
Angiotensin Type 2 Receptor ◽  
Angiotensin Type

scholarly journals Cell Growth Inhibition and Functioning of Human Somatostatin Receptor Type 2 Are Modulated by Receptor Heterodimerization

2008 ◽  
Vol 22 (10) ◽  
pp. 2278-2292 ◽  
Author(s):  
Michael Grant ◽  
Haydar Alturaihi ◽  
Philippe Jaquet ◽  
Brian Collier ◽  
Ujendra Ujendra
Keyword(s):  
Cell Growth ◽  
Growth Inhibition ◽  
Somatostatin Receptor ◽  
Receptor Type ◽  
Cell Growth Inhibition

Differential Activation of the STAT Pathway by Angiotensin II via Angiotensin Type 1 and Type 2 Receptors in Cultured Human Fetal Mesangial Cells

2001 ◽  
Vol 70 (3) ◽  
pp. 265-273 ◽  
Author(s):  
Frank A. Seebach ◽  
Thomas Welte ◽  
Xin-Yuan Fu ◽  
Lutz-Henning Block ◽  
Michael Kashgarian
Keyword(s):  
Angiotensin Ii ◽  
Mesangial Cells ◽  
Differential Activation ◽  
Angiotensin Type ◽  
Stat Pathway

scholarly journals Ontogeny of angiotensin type 2 and type 1 receptor expression in mice

2012 ◽  
Vol 13 (3) ◽  
pp. 341-352 ◽  
Author(s):  
Juan Gao ◽  
Jie Chao ◽  
Karma-Jaya K Parbhu ◽  
Li Yu ◽  
Liang Xiao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Protein Expression ◽  
Total Protein ◽  
Receptor Expression ◽  
Mrna Levels ◽  
Adult Mice ◽  
Angiotensin Type 2 Receptor ◽  
Angiotensin Type

In the current experiment, we determined angiotensin type 2 receptor (AT2R) and angiotensin type 1 receptor (AT1R) protein expression by western blot analysis in developing normal mice. The results indicate that: (1) in all detected brain regions and in the spinal cord, adult mice exhibited significantly higher AT2R expression and lower AT1R expression in total protein extracts compared to fetuses and neonates; (2) other major organs, including heart, lung, liver and kidney, exhibited the same expression pattern as the brain and spinal cord; (3) reciprocal changes in AT2R and AT1R expression were found in the total protein extracts from the brainstems of mice from one-day prenatal to six weeks of age, and there was a negative correlation between AT2R and AT1R protein expression; (4) in both membrane and cytosolic fractions from the brainstem, adult mice exhibited higher AT2R and lower AT1R expression than did fetuses and neonates; and (5) in the brainstem, there were no significant differences in AT2R and AT1R messenger RNA (mRNA) levels among fetal, neonatal and adult mice. The above results reconfirmed our previous finding in rats that adult animals have higher AT2R and lower AT1R expression compared to fetuses and neonates. These data imply an involvement of AT1R in fetal development and of AT2R in adult function.

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