scholarly journals Doxazosin Suppresses the Morning Increase in Blood Pressure and Sympathetic Nervous Activity in Patients with Essential Hypertension.

1997 ◽  
Vol 20 (3) ◽  
pp. 149-156 ◽  
Author(s):  
Yoshiyuki Kawano ◽  
Osamu Tochikubo ◽  
Yasujiro Watanabe ◽  
Eiji Miyajima ◽  
Masao Ishii
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous

Cerebral metabolism and its relationship with sympathetic nervous activity in essential hypertension

1996 ◽  
Vol 14 (8) ◽  
pp. 951???960 ◽  
Author(s):  
Gavin W. Lambert ◽  
Mario Vaz ◽  
Chakravarthi Rajkumar ◽  
Helen S. Cox ◽  
Andrea G. Turner ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Cerebral Metabolism ◽  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous

Choice of Control Groups in the Appraisal of Sympathetic Nervous Activity in Essential Hypertension

1979 ◽  
Vol 57 (4) ◽  
pp. 339-344 ◽  
Author(s):  
D. H. Jones ◽  
Carlene A. Hamilton ◽  
J. L. Reid
Keyword(s):  
Essential Hypertension ◽  
Nervous Activity ◽  
Plasma Noradrenaline ◽  
Sympathetic Nervous Activity ◽  
Urinary Catecholamine ◽  
Control Groups ◽  
Laboratory Staff ◽  
Metabolite Concentrations ◽  
Vanillyl Mandelic Acid ◽  
Sympathetic Nervous

1. Plasma noradrenaline concentrations were similar in normotensive and hypertensive outpatients, but were significantly lower in laboratory control subjects. 2. Standing plasma noradrenaline concentrations were similar in all three groups. 3. Urinary vanillyl mandelic acid, catecholamines and metanephrines were also similar in the normotensive and hypertensive groups. 4. Laboratory controls, possibly because of familiarity with the techniques of sphygmomanometry and blood sampling, may attain a ‘basal’ resting level of sympathetic nervous discharge more readily and rapidly than subjects who are unfamiliar with such procedures. 5. After orthostatic stimulation by standing for 2 min, the activity of the sympathetic nervous system, as determined by pulse rate and plasma noradrenaline concentrations, was similar in the three groups, despite the lower starting values in the laboratory staff. 6. The absence of differences in plasma noradrenaline or urinary catecholamine and metabolite concentrations does not support the hypothesis of excessive sympathetic nervous activity in essential hypertension.

Abstract 5430: Obstructive Sleep Apnoea Exacerbates Muscular Sympathetic Nervous Activity in Patients with Metabolic Syndrome

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Ivani C Trombetta ◽  
Cristiane M Nunes ◽  
Luciano F Drager ◽  
Raffael F Fraga ◽  
Maria Janieire N Alves ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Heart Rate ◽  
Oxygen Saturation ◽  
Obstructive Sleep Apnoea ◽  
Nervous Activity ◽  
Sleep Apnoea ◽  
Sympathetic Nervous Activity ◽  
Obstructive Sleep ◽  
Sympathetic Nervous

Obstructive sleep apnoea (OSA) and metabolic syndrome (MetS) independently increases muscular sympathetic nervous activity (MSNA). Unknown is whether OSA has an additive effect on MSNA in patients with MetS. We tested the hypothesis that: OSA would have an additive effect on MSNA in patients with MetS. In addition, we studied whether the increase in MSNA in patients with MetS is associated with alteration in arterial baroreflex sensitivity (BRS). Twenty four patients with MetS diagnosed according ATP-III were divided in two groups: MetS+OSA (n=14) and MetS (n=10). They were matched for age, body mass index, waist circumference, and metabolic profile: OSA was defined by an apnoea/hypopnoea index (AHI)>15 events/hour by polysonography. MSNA was recorded directly from the peroneal nerve using the technique of microneurography. Blood pressure (BP) was monitored on a beat-by-beat basis (Finapress) and heart rate by ECG. BRS was analyzed by spontaneous BP and heart rate fluctuations. AHI was higher (42±9 vs. 7±1 events/h, P =0.0001) and minimum oxygen saturation lower (77±2 vs. 87±1 %, P =0.001) in MetS+OSA patients. Patients MetS+OSA had higher MSNA (55±3 vs. 43±2 bursts/100 beats, P =0.01) and systolic BP (158±4 vs.144±3 mmHg, P =0.01) when compared with patients with MetS without OSA. Further analysis showed that AHI and minimum oxygen saturation have significant correlation with MSNA (r=0.65; P =0.001 and r=−0.48; P =0.017, respectively). Patients with MetS+OSA had lower BRS for increases (7.8±0.9 vs. 13.4 ± 1.4 msec/mmHg, P =0.01) and decreases (7.2±0.9 vs. 13.2 ± 2.0 msec/mmHg, P =0.03) in blood pressure than patients with MetS without OSA. MSNA significantly correlated with BRS during spontaneous increases in blood pressure (r=−0.56, P =0.01). OSA exacerbates MSNA in patients with MetS. In addition, the augmented MSNA in patients with MetS+OSA is associated with reduced BRS. These findings suggest that OSA increases the risk for cardiovascular disease in patients with MetS.

HEMODYNAMIC REACTIONS IN CIVIL AVIATION PILOTS TO SIMULATOR TRAINING

2021 ◽  
Vol 55 (5) ◽  
pp. 25-30
Author(s):  
V.V. Serikov ◽  
◽  
E.V. Zibarev ◽  
O.I. Yushkova ◽  
Kh.T. Oniani ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous Activity ◽  
Holter Monitoring ◽  
Simulator Training ◽  
Civil Aviation ◽  
Stress Index ◽  
Sympathetic Nervous Activity ◽  
Cardiovascular Monitoring ◽  
Sympathetic Nervous ◽  
Aviation Pilots

The paper presents the data of cardiovascular monitoring of civil pilots in the process of simulator training that included 24-hr BP and Holter monitoring and calculation of cardiac interval variation and Baevsky's stress index. Blood pressure increases correlated with a psycho-emotional stress level. Take-off and landing overstrained the cardiovascular system significantly. According to the Holter data, 42 % pilots had rhythmic disorders, ventricular and supraventricular extrasystoles; 50 % pilots had an expressed elevation of the sympathetic nervous activity.

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