scholarly journals Combined Effects of the Angiotensin II Antagonist Candesartan Cilexetil(TCV-116) and Other Classes of Antihypertensive Drugs in Spontaneously Hypertensive Rats.

1996 ◽  
Vol 19 (4) ◽  
pp. 247-254 ◽  
Author(s):  
Takeo Wada ◽  
Tsukasa Sanada ◽  
Mami Ojima ◽  
Ray Kanagawa ◽  
Kohei Nishikawa ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Spontaneously Hypertensive Rats ◽  
Candesartan Cilexetil ◽  
Antihypertensive Drugs ◽  
Combined Effects ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Angiotensin Ii Antagonist

scholarly journals Candesartan prevents L-NAME-induced cardio-renal injury in spontaneously hypertensive rats beyond hypotensive effects

2001 ◽  
Vol 2 (1_suppl) ◽  
pp. S84-S90 ◽  
Author(s):  
Daniel Casellas ◽  
Abderraouf Herizi ◽  
Annie Artuso ◽  
Albert Mimran ◽  
Bernard Jover
Keyword(s):  
Angiotensin Ii ◽  
Cardiac Hypertrophy ◽  
Renal Injury ◽  
Spontaneously Hypertensive Rats ◽  
Candesartan Cilexetil ◽  
Vascular Lesions ◽  
Heart Weight ◽  
Hypertensive Rats ◽  
Renal Protection ◽  
Spontaneously Hypertensive

Our goal was to assess the cardiovascular and renal protection afforded by angiotensin II type 1-receptor blockade against NG-nitro-L-arginine methyl ester (L-NAME)-exacerbated hypertension in young spontaneously hypertensive rats (SHR), in comparison with the antihypertensive drug, hydralazine. Male SHR were assigned to four groups (n=8 per group): no treatment (controls); L-NAME-treated group (20 mg/kg/day, 10 days, orally); co-treatment with L-NAME and hydralazine (15 mg/kg/day, by gavage); co-treatment with L-NAME and candesartan cilexetil (10 mg/kg/day, by gavage), i.e. at a dose that inhibited acute pressor responses to 5—20 ng angiotensin II. One animal died in the L-NAME group, and tail-cuff systolic blood pressure (SBP) increased significantly compared with controls to 201±5 mmHg. Albumin excretion increased 235-fold in L-NAME-treated rats. Heart weight index averaged 3.5±0.1 and 3.8±0.1 mg/g body weight (p<0.05) in control and L-NAME rats, respectively, indicating moderate cardiac hypertrophy induced by L-NAME. Preglomerular vascular lesions affected 63±6% of interlobular arteries and 10±2% of afferent arterioles (vs. 8±3 and 0.8±0.4% in controls, respectively). Hydralazine and candesartan cilexetil treatment similarly reduced SBP to 153±7, and 165±6 mmHg, respectively. However, candesartan provided more protection, in terms of no significant change in albuminuria (vs. 25-fold increase with hydralazine), regression of cardiac hypertrophy, frequency of vascular lesions and histological indices of renal injury maintained within control values. In conclusion, candesartan cilexetil prevented L-NAME-exacerbated hypertension and associated cardio-renal injury in young SHR, the beneficial effects exceeding those of hydralazine.

scholarly journals Influence of Angiotensin II Subtype 2 Receptor (AT2R) Antagonist, PD123319, on Cardiovascular Remodelling of Aged Spontaneously Hypertensive Rats during Chronic Angiotensin II Subtype 1 Receptor (AT1R) Blockade

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Emma S. Jones ◽  
M. Jane Black ◽  
Robert E. Widdop
Keyword(s):  
Angiotensin Ii ◽  
Spontaneously Hypertensive Rats ◽  
Candesartan Cilexetil ◽  
Ventricular Volume ◽  
Left Ventricular ◽  
Hypertensive Rats ◽  
Simultaneous Treatment ◽  
Spontaneously Hypertensive ◽  
Severe Degree

Cardiac AT2R expression is upregulated in the normal process of aging. In this study we determined the contribution of AT2R to chronic antihypertensive and remodelling effects of AT1R blockade in aged hypertensive rats. Adult (20 weeks) and senescent (20 months) spontaneously hypertensive rats (SHRs) were treated with either the AT1R antagonist, candesartan cilexetil (2 mg/kg/day), the AT2R antagonist, PD123319 (10 mg/kg/day), or a combination of the 2 compounds. Mean arterial pressure (MAP) and left ventricular volume were markedly decreased by candesartan cilexetil, however, simultaneous treatment with PD123319 had no additional effect on either parameter. Perivascular fibrosis was significantly reduced by candesartan cilexetil in aged animals only, and this effect was reversed by concomitant PD123319 administration. Vascular hypertrophy was reduced by candesartan cilexetil, and these effects were reversed by simultaneous PD123319. These results suggest that AT2R stimulation does not significantly influence the antihypertensive effect of chronic AT1R blockade, but plays a role in the regulation of vascular structure. The severe degree of cardiac perivascular fibrosis in senescent animals was regressed by AT1R blockade and this effect was reversed by simultaneous AT2R inhibition, demonstrating an antifibrotic role of AT2R stimulation in the aging hypertensive heart.

Angiotensin II Increases Norepinephrine Turnover in the Anteroventral Third Ventricle of Spontaneously Hypertensive Rats

Hypertension ◽  
1996 ◽  
Vol 28 (2) ◽  
pp. 224-227 ◽  
Author(s):  
Akira Tsukashima ◽  
Takuya Tsuchihashi ◽  
Isao Abe ◽  
Kaoru Nakamura ◽  
Hideyuki Uchimura ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Spontaneously Hypertensive Rats ◽  
Third Ventricle ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Norepinephrine Turnover
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