Myoepithelial Molecular Markers in Human Breast Carcinoma PMC42-LA Cells are Induced by Extracellular Matrix and Stromal Cells

2006 ◽  
Author(s):  
Stephanie Lebret ◽  
Donald Newgreen ◽  
Mark Waltham ◽  
John Price ◽  
Erik Thompson ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Molecular Markers ◽  
Breast Carcinoma ◽  
Stromal Cells ◽  
Human Breast Carcinoma ◽  
Human Breast

scholarly journals Stromal CCL5 Promotes Breast Cancer Progression by Interacting with CCR3 in Tumor Cells

2021 ◽  
Vol 22 (4) ◽  
pp. 1918
Author(s):  
Mio Yamaguchi ◽  
Kiyoshi Takagi ◽  
Koki Narita ◽  
Yasuhiro Miki ◽  
Yoshiaki Onodera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Tumor Progression ◽  
Tumor Cells ◽  
Cancer Progression ◽  
Stromal Cells ◽  
Human Breast Carcinoma ◽  
Breast Cancer Patients ◽  
Breast Carcinomas ◽  
Human Breast

Chemokines secreted from stromal cells have important roles for interactions with carcinoma cells and regulating tumor progression. C-C motif chemokine ligand (CCL) 5 is expressed in various types of stromal cells and associated with tumor progression, interacting with C-C chemokine receptor (CCR) 1, 3 and 5 expressed in tumor cells. However, the expression on CCL5 and its receptors have so far not been well-examined in human breast carcinoma tissues. We therefore immunolocalized CCL5, as well as CCR1, 3 and 5, in 111 human breast carcinoma tissues and correlated them with clinicopathological characteristics. Stromal CCL5 immunoreactivity was significantly correlated with the aggressive phenotype of breast carcinomas. Importantly, this tendency was observed especially in the CCR3-positive group. Furthermore, the risk of recurrence was significantly higher in the patients with breast carcinomas positive for CCL5 and CCR3 but negative for CCR1 and CCR5, as compared with other patients. In summary, the CCL5-CCR3 axis might contribute to a worse prognosis in breast cancer patients, and these findings will contribute to a better understanding of the significance of the CCL5/CCRs axis in breast carcinoma microenvironment.

scholarly journals The Nuclear Pool of Tetraspanin CD9 Contributes to Mitotic Processes in Human Breast Carcinoma

2014 ◽  
Vol 12 (12) ◽  
pp. 1840-1850 ◽  
Author(s):  
Germana Rappa ◽  
Toni M. Green ◽  
Aurelio Lorico
Keyword(s):  
Breast Carcinoma ◽  
Human Breast Carcinoma ◽  
Human Breast
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