A novel in vitro dermal wound healing model incorporating a response to mechanical wounding and repopulation of a fibrin provisional matrix

2003 ◽  
Author(s):  
Ronan O'Leary ◽  
Edward Wood
Keyword(s):  
Wound Healing ◽  
Mechanical Wounding ◽  
Dermal Wound Healing ◽  
Wound Healing Model ◽  
Dermal Wound ◽  
Healing Model

scholarly journals The effects of acacia honey on in vitro corneal abrasion wound healing model

2015 ◽  
Vol 16 (1) ◽  
pp. 2 ◽  
Author(s):  
Choy Ker-Woon ◽  
Norzana Abd Ghafar ◽  
Chua Kien Hui ◽  
Yasmin Mohd Yusof ◽  
Wan Wan Ngah
Keyword(s):  
Wound Healing ◽  
Corneal Abrasion ◽  
Acacia Honey ◽  
Wound Healing Model ◽  
Healing Model

scholarly journals Effects of fibrin-binding oligopeptide derived from fibronectin on osteoblast-like cell migration in in vitro wound healing model

2018 ◽  
Vol 29 ◽  
pp. 122-122
Author(s):  
Yoojin Hong ◽  
Sung Tae Kim ◽  
Ki-Tae Koo ◽  
Yang-Jo Seol ◽  
Yong-Moo Lee ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cell Migration ◽  
Wound Healing Model ◽  
Healing Model

scholarly journals Effect of Unloading Condition on the Healing Process and Effectiveness of Platelet Rich Plasma as a Countermeasure: Study on In Vivo and In Vitro Wound Healing Models

2020 ◽  
Vol 21 (2) ◽  
pp. 407 ◽  
Author(s):  
Francesca Cialdai ◽  
Alessandra Colciago ◽  
Desiré Pantalone ◽  
Angela Maria Rizzo ◽  
Stefania Zava ◽  
...  
Keyword(s):  
Wound Healing ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Physical Factors ◽  
Medical Evacuation ◽  
Fibroblast Migration ◽  
Wound Healing Model ◽  
Healing Model

Wound healing is a very complex process that allows organisms to survive injuries. It is strictly regulated by a number of biochemical and physical factors, mechanical forces included. Studying wound healing in space is interesting for two main reasons: (i) defining tools, procedures, and protocols to manage serious wounds and burns eventually occurring in future long-lasting space exploration missions, without the possibility of timely medical evacuation to Earth; (ii) understanding the role of gravity and mechanical factors in the healing process and scarring, thus contributing to unravelling the mechanisms underlying the switching between perfect regeneration and imperfect repair with scarring. In the study presented here, a new in vivo sutured wound healing model in the leech (Hirudo medicinalis) has been used to evaluate the effect of unloading conditions on the healing process and the effectiveness of platelet rich plasma (PRP) as a countermeasure. The results reveal that microgravity caused a healing delay and structural alterations in the repair tissue, which were prevented by PRP treatment. Moreover, investigating the effects of microgravity and PRP on an in vitro wound healing model, it was found that PRP is able to counteract the microgravity-induced impairment in fibroblast migration to the wound site. This could be one of the mechanisms underlying the effectiveness of PRP in preventing healing impairment in unloading conditions.

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