scholarly journals Multi-Focal Splenic Tumour in a Belgian Patient and a Brief Review of the Literature on Littoral Cell Angioma

2020 ◽  
Author(s):  
Maaike Ramael ◽  
Patrick Schoeters ◽  
Karl De Pooter ◽  
Frederik Van Sonhoven ◽  
Hilde Van Steelandt ◽  
...  
Keyword(s):  
Vascular Tumour ◽  
Review Of The Literature ◽  
Littoral Cell ◽  
Littoral Cell Angioma ◽  
First Case ◽  
Littoral Cells ◽  
Splenic Red Pulp ◽  
Underlying Pathology ◽  
Red Pulp

We describe the case of a 66-year-old woman with littoral cell angioma (LCA) confirmed by histopathology and immunohistochemistry, to our knowledge the first case in Belgium. LCA is an extremely rare primary vascular tumour of the splenic red pulp, probably originating from littoral cells. If a splenic mass and nodules are incidentally identified on imaging and the patient has no associated signs or symptoms, LCA should be suspected. Histopathology and adjacent techniques are mandatory for definitive diagnosis. Splenectomy followed by adequate follow-up is necessary to exclude underlying pathology.

scholarly journals A Rare Case of Splenic Littoral Cell Angioma in a Child

2014 ◽  
Vol 6 (02) ◽  
pp. 117-120
Author(s):  
Recep Bedir ◽  
İbrahim Şehitoğlu ◽  
Ahmet Salih Calapoğlu ◽  
Cüneyt Yurdakul
Keyword(s):  
Clinical Situation ◽  
Definitive Diagnosis ◽  
Vascular Neoplasm ◽  
Littoral Cell ◽  
Littoral Cell Angioma ◽  
Littoral Cells ◽  
Long Term Follow Up ◽  
Red Pulp

ABSTRACTLittoral cell angioma (LCA) is a rare, benign primary vascular neoplasm of the spleen. The tumor originates from the littoral cells lining the sinuses of the red pulp of the spleen. Preoperative distinction of this tumor from other benign or malign splenic lesions is difficult. Radiologically most cases present as multiple nodules. Definitive diagnosis can only be made histopathologically and immunohistochemically following splenectomy. This clinical situation can coexist with various malignancies and autoimmune disorders. Even though, it is mostly benign, since it has the potential to become malignant after splenectomy, long-term follow-up is required. We present an LCA case, which appeared as a solitary mass in the spleen of an 11-year-old girl with abdominal pain admitted to our hospital.

Littoral cell angioma with splenic rupture in pregnancy

2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Ann McHugh ◽  
Catherine O’Gorman ◽  
Sharon Cooley ◽  
Gerry McEntee ◽  
Naomi Burke
Keyword(s):  
Splenic Rupture ◽  
Rare Event ◽  
Vascular Tumour ◽  
Third Trimester ◽  
Unique Case ◽  
Littoral Cell ◽  
Littoral Cell Angioma ◽  
Splenic Red Pulp ◽  
In Pregnancy ◽  
Red Pulp

Abstract Splenic rupture in pregnancy is a rare event. It is generally due to trauma or an underlying splenic pathology. Timely diagnosis and intervention of splenic rupture is essential given the high rates of associated maternal and fetal morbidity and mortality. This case illustrates a 38 year old lady in the third trimester of pregnancy who presented with maternal collapse and a non-reassuring foetal heart rate tracing following a fall at home one week previously. A massive hemoperitoneum was identified at caesarean section and a splenectomy was performed. Histological examination revealed a littoral cell angioma of the spleen. This vascular tumour arising in the splenic red pulp sinuses is a rare entity and specific immunophenotypic features help distinguish it from other vascular tumours of the spleen. Both trauma and an underlying splenic pathology led to splenic rupture in this unique case.

scholarly journals Littoral cell angioma mimicking metastatic tumors

2015 ◽  
Vol 28 (4) ◽  
pp. 247-249
Author(s):  
Justyna Szumilo ◽  
Anna Ostrowska ◽  
Malgorzata Zdunek ◽  
Slawomir Rudzki ◽  
Tomasz Chroscicki ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Vascular Tumor ◽  
Littoral Cell ◽  
Littoral Cell Angioma ◽  
Littoral Cells ◽  
Upper Abdominal ◽  
Splenic Red Pulp ◽  
Tomography Appearance ◽  
Red Pulp

Abstract Littoral cell angioma is a rare primary, vascular tumor thought to originate from the endothelial cells lining the sinuses of the splenic red pulp (the “littoral cells”). It is a benign, usually asymptomatic lesion diagnosed incidentally. Ultrasound and tomography appearance is not characteristic and histopathological examination is required. This work provides a case-study of littoral cell angioma which was seen in a 55-year-old female who complained of non-specific upper abdominal pain. Computed tomography revealed multiple hypo-attenuated splenic lesions suggestive for metastasis. A splenectomy was performed and routine microscopic examination supported by immunohistochemistry reactions with CD68, CD34 and CD31 showed littoral cell angioma.

Littoral Cell Angioma of the Spleen: An Additional Report of Four Cases with Emphasis on the Association with Visceral Organ Cancers

1998 ◽  
Vol 84 (5) ◽  
pp. 595-599 ◽  
Author(s):  
Michele Bisceglia ◽  
Joshua Z. Sickel ◽  
Felice Giangaspero ◽  
Vito Gomes ◽  
Mostafà Amini ◽  
...  
Keyword(s):  
Vascular Tumor ◽  
Clinical Syndrome ◽  
Vascular Tumors ◽  
Littoral Cell ◽  
Littoral Cell Angioma ◽  
Tentorial Meningioma ◽  
Clinical Observations ◽  
Littoral Cells ◽  
Tumors Of The Liver

Aims and background Littoral cell angioma (LCA) is an uncommon vascular tumor of the spleen recently described and interpreted as the tumoral counterpart of the normally present littoral cells lining the splenic sinus channels of red pulp. The diagnosis of LCA is suggested by a quite characteristic morphology and confirmed by the demonstration of a hybrid endothelial/histiocytic phenotype. Methods Four original and previously unreported cases of LCA are presented. All four splenic vascular tumors were investigated by light microscopy and immunohistochemistry for endothelial and histiocytic markers. Results All four cases were associated with visceral epithelial malignancies (colorectal adenocarcinoma in two cases, renal and pancreatic adenocarcinoma in one case each). One case was also associated with an intracranial tentorial meningioma. Conclusions We consider our findings as a novelty and signal the possible existence of a clinical syndrome. Five of a total of 21 previously reported cases in the literature were also described as being associated with other cancers (non-Hodgkin's lymphoma in two cases, two not further specified tumors of the liver and brain, an epithelial ovarian cancer, and a non-small cell lung cancer in one case each). Close follow-up and careful investigation in search of a second visceral neoplasm are strongly recommended in cases of LCA, but further clinical observations and more in-depth genetic and molecular studies are needed before any valid conclusions can be drawn.

scholarly journals Atipical immunophenotype in a littoral cell angioma

2009 ◽  
Vol 66 (1) ◽  
pp. 63-65 ◽  
Author(s):  
Radoje Colovic ◽  
Nada Suvajdzic ◽  
Nikica Grubor ◽  
Natasa Colovic ◽  
Tatjana Terzic
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Final Diagnosis ◽  
Vascular Tumor ◽  
Littoral Cell ◽  
Littoral Cell Angioma ◽  
Negative Case ◽  
Splenic Neoplasm ◽  
Littoral Cells ◽  
Red Pulp

Background. Littoral-cell angioma (LCA) is a recently described benign vascular tumor of the spleen, whose imaging and pathologic characteristics have been discussed only by a few authors. The tumor is characterized by a mixture of papillary and cystic areas lined by neoplastic cells deriving from normal splenic lining - littoral cells. The neoplastic LCA cells express both endothelial and histiocytic antigens associated with CD8 negativity, compared with the normal endothelium of the venous sinuses of the spleen red pulp that only expresses endothelial antigens and CD8 positivity. Therefore, the typical and characteristic immunohistochemical pattern of the LCA is as follows: CD31, CD68, CD163, CD21, FVIII antigen positive; CD34, CD8 negative. Case report. We reported a 60-year-old male with moderate nodular splenomegaly with one large hypoechogenic solid lesion and mild thrombocytopenia in whom the diagnosis of LCA was made after the elective splenectomy. Namely, histopathological and immunohistochemical data allowed a final diagnosis of classical LCA in spite of CD21 negativity. As far as we know this is the first reported CD21-negative LCA patient. Histological specimens were presented and differential diagnoses discussed. Conclusion. Littoral-cell angioma is a very rare benign splenic neoplasm that should be considered in the differential diagnosis of multinodular splenomegaly, particularly if the patient has the signs of hypersplenism.

Littoral cell angioma: A case and review of the literature

2011 ◽  
Vol 6 (3) ◽  
Author(s):  
Tarek Hanna ◽  
Deborah A. Baumgarten ◽  
Theodore M Friedman
Keyword(s):  
Review Of The Literature ◽  
Littoral Cell ◽  
Littoral Cell Angioma

scholarly journals Littoral cell angioma of the spleen: A case report

2020 ◽  
Vol 8 ◽  
pp. 2050313X2095987
Author(s):  
Vaclav Opatrny ◽  
Vladislav Treska ◽  
Tomas Waloschek ◽  
Jiri Molacek
Keyword(s):  
Case Report ◽  
Metastatic Lesion ◽  
Vascular Tumors ◽  
Rare Tumor ◽  
Littoral Cell ◽  
Littoral Cell Angioma ◽  
Uncommon Disease ◽  
Visceral Malignancy ◽  
Red Pulp

Spleen tumors are an uncommon disease. Littoral cell angioma belongs to the group of vascular tumors. It is believed that this tumor originates from the tissue of the red pulp sinuses, specifically from the cells that are lining the sinuses. If this rare tumor is diagnosed, it is necessary to search for synchronous or metachronous visceral neoplasia. Littoral cell angioma can also mimic metastatic lesion of the spleen. This case report wants to draw attention on this rare tumor of the spleen which is very often associated with other visceral malignancy.

Littoral Cell Angioma and Angiosarcoma of the Spleen: Report of Two Cases in Siblings and Review of the Literature

2011 ◽  
Vol 16 (4) ◽  
pp. 863-867 ◽  
Author(s):  
Michael Kranzfelder ◽  
Margit Bauer ◽  
Thomas Richter ◽  
Martina Rudelius ◽  
Martin Huth ◽  
...  
Keyword(s):  
Review Of The Literature ◽  
Littoral Cell ◽  
Littoral Cell Angioma
Sign in / Sign up

Export Citation Format

Share Document