scholarly journals Cryptogenic Pyogenic Liver Abscess Due to Fusobacterium nucleatum in an Immunocompetent Patient

2020 ◽  
Author(s):  
Neeraja Swaminathan ◽  
Francisco Aguilar
Keyword(s):  
Liver Abscess ◽  
Fusobacterium Nucleatum ◽  
Pyogenic Liver Abscess ◽  
Immunocompetent Patient ◽  
Immunocompetent Host ◽  
Source Of Infection ◽  
Function Test ◽  
History Of ◽  
Anaerobic Infections ◽  
Dental Work

In this case, a 76-year-old female presented with 3–4 days of fever with no other localizing signs. Notably, she had had an untreated Fusobacterium bacteraemia approximately 8 weeks prior to admission. She underwent abdominal imaging which demonstrated a liver abscess and had percutaneous drainage of the same. Blood and pus cultures both grew Fusobacterium nucleatum, which is an unusual organism to be associated with a liver abscess, especially in an immunocompetent host with no risk factors for this condition. Interestingly, this patient did not have any history of dental work, instrumentation, liver function test (LFT) abnormalities and no extrahepatic source for the abscess. This case highlights the importance of having a high index of clinical suspicion for an occult source of infection and emphasizes the importance of following up on cultures even after discharge of a patient, since anaerobic infections such as those caused by Fusobacterium can have a largely indolent course.

scholarly journals Fusobacterium Nucleatum : An Atypical Cause of Pyogenic Liver Abscess in an Apparently Immunocompetent Patient

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Yusoff AR ◽  
Abd Razak NA ◽  
Samsuddin S ◽  
Mokhtar S
Keyword(s):  
Liver Abscess ◽  
Percutaneous Drainage ◽  
Fusobacterium Nucleatum ◽  
Pyogenic Liver Abscess ◽  
Enteric Bacteria ◽  
Operative Management ◽  
Immunocompetent Patient ◽  
Immunocompromised Status ◽  
Anaerobic Infections ◽  
Non Operative Management

Pyogenic liver abscess is an uncommon but potentially lethal infection if left untreated. Enteric bacteria and anaerobes are the most common causative organisms of pyogenic liver abscess. Although most infections are of a polymicrobial nature, monomicrobial infections are possible. An immunocompromised status and the presence of periodontal disease are the risk factors for liver abscess caused by these rare, monomicrobial anaerobic infections. Here, we report on a successful non-operative management of a case of multiloculated pyogenic liver abscess caused by Fusobacterium nucleatum in a young, healthy, immunocompetent male patient. The diagnosis was established by radiological imaging and was based on a positive aspirate culture, whereas the mainstay of treatment comprised percutaneous drainage and a prolonged course of antibiotics. Thus, the patient was successfully treated with a 2-week course of intravenous imipenem/cilastatin while he was on percutaneous drainage, and he is now doing well.

scholarly journals Concurrent fusobacterial pyogenic liver abscess and empyema

2019 ◽  
Vol 12 (10) ◽  
pp. e231994
Author(s):  
Ahmed Gohar ◽  
Fady Jamous ◽  
Mohamed Abdallah
Keyword(s):  
Septic Shock ◽  
Pleural Effusion ◽  
Liver Abscess ◽  
Rare Case ◽  
Fusobacterium Nucleatum ◽  
Pyogenic Liver Abscess ◽  
Abdominal Discomfort ◽  
History Of ◽  
Fusobacterium Varium

We present a very rare case of concurrent empyema and liver abscess caused by Fusobacterium. Our patient presented with 3-month history of subtle abdominal discomfort and cough leading to eventually presenting with marked chest pain, dyspnoea and septic shock. CT revealed a liver abscess and large right-sided pleural effusion. Drainage of the pleural effusion yielded gross pus with the growth of Fusobacterium varium, while drainage of the liver abscess yielded Fusobacterium nucleatum. The patient responded to drainage and antibiotic therapy with resolution of symptoms and decrease in the size of empyema and abscess on follow-up imaging. We also include a review if literature of related fusobacterial infections.

scholarly journals More than Pus – Primary Hepatic Epithelioid Angiomyolipoma Masquerading as Liver Abscess

2021 ◽  
pp. 1-8
Author(s):  
Wen Hao Justin Leong ◽  
Xia Huang Andrew Tan ◽  
Ennaliza Salazar
Keyword(s):  
Liver Abscess ◽  
Epigastric Pain ◽  
Epithelioid Angiomyolipoma ◽  
Rare Type ◽  
Function Test ◽  
History Of ◽  
Cluster Of Differentiation ◽  
Epithelioid Variant ◽  
Minimal Fluid ◽  
Mesenchymal Tumours

Hepatic angiomyolipomas (AML) are rare mesenchymal tumours of which the epithelioid type is a rare type with malignant potential. We report a case of primary hepatic epithelioid angiomyolipoma masquerading as liver abscess. A 46-year-old man presented with a 5-day history of fever with epigastric pain and nausea. On the night of admission, his temperature spiked to 39°C, his blood pressure was 135/79, his heart rate 98, his liver function test revealed albumin 37 g/L, bilirubin 25 μmol/L, ALP 298 U/L, ALT 247 U/L, and AST 344 U/L. The clinical suspicion was hepatobiliary sepsis and intravenous ceftriaxone was commenced. CT of the abdomen showed an ill-defined hypodense focus in segment 4A/8 (4.5 × 3.5 cm) with a minimal fluid component implying a developing abscess or phlegmon. The images were reviewed by a radiologist and showed minimal fluid for percutaneous drainage. MRI of the liver was performed to further characterize the lesion and revealed a solid mass with nodular areas of arterial enhancement and washout, suspicious of neoplasm. Ultrasound-guided liver biopsy of the lesion was performed. Histology showed a histiocyte-rich epithelioid neoplasm consistent with the epithelioid variant of AML. Immunohistochemical staining was positive for human melanoma black 45, melan-A and cluster of differentiation 68. He successfully underwent liver resection of segment 4A/8 after 6 weeks of antibiotics. To our knowledge, this is the first reported case in the literature of primary hepatic epithelioid angiomyolipoma masquerading as liver abscess.

Fusobacterium nucleatum detected simultaneously in a pyogenic liver abscess and advanced sigmoid colon cancer

Anaerobe ◽  
2017 ◽  
Vol 48 ◽  
pp. 144-146 ◽  
Author(s):  
Ryuta Shigefuku ◽  
Tsunamasa Watanabe ◽  
Yuki Kanno ◽  
Hiroki Ikeda ◽  
Hiroyasu Nakano ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Sigmoid Colon ◽  
Liver Abscess ◽  
Fusobacterium Nucleatum ◽  
Pyogenic Liver Abscess ◽  
Sigmoid Colon Cancer

scholarly journals Liver Abscess Caused by Fusobacterium nucleatum: A Case Report

2021 ◽  
Vol 14 (4) ◽  
Author(s):  
Wenhao Wu ◽  
Wenjia Fan ◽  
Zhewen Zhou ◽  
Shouhao Wang ◽  
Chengan Xu ◽  
...  
Keyword(s):  
Liver Abscess ◽  
Pathogenic Bacteria ◽  
Anaerobic Bacteria ◽  
Fusobacterium Nucleatum ◽  
Pyogenic Liver Abscess ◽  
Microbial Detection ◽  
Specimen Collection ◽  
First Case ◽  
Positive Rate ◽  
Bacteria Culture

Introduction: Pyogenic liver abscess (PLA) is a serious infectious disease of the liver. PLA caused by Fusobacterium nucleatum is extremely rare. Here we report the first case of liver abscess caused by F. nucleatum in China. Case Presentation: The case was a 34-year-old female patient admitted to the hospital due to high fever. The diagnosis of liver abscess was confirmed by imaging studies and liver puncture. We finally confirmed the pathogen as F. nucleatum by next-generation sequencing (NGS). After the targeted anti-infective treatment, the patient recovered and discharged. Conclusions: As a new microbial detection method, NGS can still help in clinical practice. In addition, to improve the positive rate of anaerobic bacteria culture, we should pay attention to avoid contact with air in the process of specimen collection when the pathogenic bacteria are suspected to be anaerobic bacteria.

scholarly journals Therapeutic Success in Amoebic and Pyogenic Liver Abscesses

2021 ◽  
Vol 3 (1) ◽  
pp. 1-10
Author(s):  
Azhari Gani ◽  
Malahayati
Keyword(s):  
Clinical Improvement ◽  
Liver Abscess ◽  
Bed Rest ◽  
Pyogenic Liver Abscess ◽  
Therapeutic Success ◽  
The Past ◽  
History Of ◽  
Surgical Sutures ◽  
Surgery Department

A 52 year old male patient presented with complaints of upper right abdominal pain since 1 month ago, worsening in the last 1 day. Fever has been complained of since 1 month ago, fever fluctuates indefinitely, comes down with fever-reducing drugs, complained of weakness. There is nausea and vomiting, vomiting 1-2 times per day, black vomit like coffee is not there. Complained about weight loss. BAK is like strong tea. Liquid defecation has been complained of since 5 weeks ago, initially liquid defecation was accompanied by mucus and blood with a frequency of 3-4 times per day for 3 days, at that time the patient went to the health center and complaints were reduced and now liquid CHAPTER 1-2 times a day is yellow, liquid, no mucus, no blood for the past 1 month. The patient is an agricultural instructor with his daily activities going down to the farm. History. History of diabetes mellitus denied. Patients diagnosed with multiple pyogenic liver abscess were treated at RSUDZA and received bed rest therapy, 1800 kcal / day soft food diet, IVFD NaCl 0.9% 20 drops per macro minute, metronidazole drip 500 mg every 8 hours, ciprofloxacin 2x 500 mg, intravenously paracetamol 1 gram every 8 hours. The patient was treated for 17 days, on the 10th day of hospitalization the patient was performed a laparotomy and multiple incisions of the liver abscess, purulent abscess fluid mixed with blood. The abscess fluid was cultured as a result of Entamoeba Colli, and metronidazole antibiotic therapy was continued. During treatment, the patient experienced clinical improvement, the patient was opened surgical sutures on the 10th and 15th day after laparotomy, the surgical wound improved, the patient experienced clinical improvement, currently the patient is still a control at the Internal Medicine and Surgery Department at Cut Nyak Dhien Meulaboh Hospital.

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