scholarly journals Pneumocephalus Associated with Aggressive Pneumococcal Meningitis

2020 ◽  
Author(s):  
Isabel I Taveira ◽  
Hipólito Nzwalo ◽  
José Sousa e Costa ◽  
Pedro Moreira
Keyword(s):  
Intensive Care Unit ◽  
Cerebrospinal Fluid ◽  
Intensive Care ◽  
Streptococcus Pneumoniae ◽  
Antibiotic Treatment ◽  
Pneumococcal Meningitis ◽  
Brain Tomography

A 44-year-old woman presented with headache and delirium. Brain tomography indicated pneumocephalus, while blood and cerebrospinal fluid cultures revealed Streptococcus pneumoniae. Despite antibiotic treatment and admission to the intensive care unit, the patient died 3 days later. Pneumocephalus in association with meningitis is very rare and may be caused by gas produced by microorganisms.

scholarly journals EVALUATION OF ANTIBIOTIC TREATMENT AND ANTIBIOTIC DE-ESCALATION IN A INTENSIVE CARE UNIT WITH SELECTIVE DIGESTIVE DECONTAMINATION

2015 ◽  
Vol 3 (Suppl 1) ◽  
pp. A2
Author(s):  
C Sánchez Ramirez ◽  
L Caipe Balcázar ◽  
S Hípola Escalada ◽  
MA Hernández Viera ◽  
M Cabrera Santana ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Antibiotic Treatment ◽  
Selective Digestive Decontamination

scholarly journals Parainfectious vasculitis due to Pneumococcal meningitis following traumatic CSF rhinorrhoea resulting in cerebellar infarction

2020 ◽  
Vol 11 (4) ◽  
pp. 102-105
Author(s):  
Ummer Karadan ◽  
Robin George Manappallil ◽  
Manoj Bhaskaran ◽  
Anoop Chandran ◽  
Ivin Panakkel Zacharia
Keyword(s):  
Cerebrospinal Fluid ◽  
Streptococcus Pneumoniae ◽  
Pneumococcal Meningitis ◽  
Cribriform Plate ◽  
Cerebellar Infarction ◽  
Traumatic Fracture ◽  
Life Threatening ◽  
Csf Rhinorrhoea ◽  
Life Threatening Complication

Parainfectious vasculitis is a rare life threatening complication of Streptococcus pneumoniae (S.pneumoniae) meningitis. There is a 19% risk of developing meningitis in the patients with cerebrospinal fluid (CSF) rhinorrhoea. The patient being reported developed CSF rhinorrhoea due to traumatic fracture of cribriform plate, followed by pneumococcal meningitis and parainfectious vasculitis resulting in cerebellar infarction.

scholarly journals Gemifloxacin Is Effective in Experimental Pneumococcal Meningitis

2000 ◽  
Vol 44 (3) ◽  
pp. 767-770 ◽  
Author(s):  
A. Smirnov ◽  
A. Wellmer ◽  
J. Gerber ◽  
K. Maier ◽  
S. Henne ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Streptococcus Pneumoniae ◽  
Standard Deviation ◽  
Pneumococcal Meningitis ◽  
Rabbit Model ◽  
Csf Levels ◽  
Experimental Pneumococcal Meningitis

ABSTRACT In a rabbit model of Streptococcus pneumoniaemeningitis, 5 mg of gemifloxacin mesylate (SB-265805) per kg/h reduced the bacterial titers in cerebrospinal fluid (CSF) almost as rapidly as 10 mg of ceftriaxone per kg/h (Δlog CFU/ml/h ± standard deviation [SD], −0.25 ± 0.09 versus −0.38 ± 0.11; serum and CSF concentrations of gemifloxacin were 2.1 ± 1.4 mg/liter and 0.59 ± 0.38 mg/liter, respectively, at 24 h). Coadministration of 1 mg of dexamethasone per kg did not affect gemifloxacin serum and CSF levels (2.7 ± 1.4 mg/liter and 0.75 ± 0.34 mg/liter, respectively, at 24 h) or activity (Δlog CFU/ml/h ± SD, −0.26 ± 0.11).

scholarly journals Cerebrospinal Fluid Penetration and Pharmacokinetics of Vancomycin Administered by Continuous Infusion to Mechanically Ventilated Patients in an Intensive Care Unit

2000 ◽  
Vol 44 (5) ◽  
pp. 1356-1358 ◽  
Author(s):  
Jacques Albanèse ◽  
Marc Léone ◽  
Bernard Bruguerolle ◽  
Marie-Laure Ayem ◽  
Bruno Lacarelle ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Cerebrospinal Fluid ◽  
Intensive Care ◽  
Continuous Infusion ◽  
The Other ◽  
Mechanically Ventilated ◽  
Mechanically Ventilated Patients ◽  
Csf Penetration ◽  
Group Serum ◽  
Ventilated Patients

ABSTRACT Cerebrospinal fluid (CSF) penetration and the pharmacokinetics of vancomycin were studied after continuous infusion (50 to 60 mg/kg of body weight/day after a loading dose of 15 mg/kg) in 13 mechanically ventilated patients hospitalized in an intensive care unit. Seven patients were treated for a sensitive bacterial meningitis and the other six patients, who had a severe concomitant neurologic disease with intracranial hypertension, were treated for various infections. Vancomycin CSF penetration was significantly higher (P< 0.05) in the meningitis group (serum/CSF ratio, 48%) than in the other group (serum/CSF ratio, 18%). Vancomycin pharmacokinetic parameters did not differ from those obtained with conventional dosing. No adverse effect was observed, in particular with regard to renal function.

scholarly journals Genetic Relationship between Streptococcus pneumoniae Isolates from Nasopharyngeal and Cerebrospinal Fluid of Two Infants with Pneumococcal Meningitis

2003 ◽  
Vol 41 (8) ◽  
pp. 3970-3972 ◽  
Author(s):  
A. L. S. S. de Andrade ◽  
F. C. Pimenta ◽  
M. C. C. Brandileone ◽  
C. A. Laval ◽  
M. L. Guerra ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Streptococcus Pneumoniae ◽  
Genetic Relationship ◽  
Pneumococcal Meningitis
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