scholarly journals An Improbable Case of Ascites

2020 ◽  
Author(s):  
Virginia Visconti ◽  
Andre Fernandes ◽  
Ismenia Oliveira
Keyword(s):  
Prostate Cancer ◽  
Cancer Metastasis ◽  
Specific Antigen ◽  
Abdominal Distension ◽  
Abdominal Ultrasound ◽  
Malignant Ascites ◽  
Prostatic Specific Antigen ◽  
Computerised Tomography ◽  
Peritoneal Implant ◽  
Prostate Cancer Metastasis

Prostate cancer is the most frequent malignancy seen in males, with about 15% of cases showing metastatic disease at diagnosis, most commonly in bones (vertebrae, ribs, long bones). However, peritoneal metastasis with malignant ascites is extremely rare and may be overlooked by physicians. We report the case of a 77-year-old man presenting with symptoms of abdominal distension, nausea and weight loss. Abdominal ultrasound and computerised tomography confirmed ascites, peritoneal carcinomatosis and an enlarged prostate. Serum and ascitic prostatic-specific antigen were both elevated. Prostate biopsy identified a prostate adenocarcinoma, while biopsy of a peritoneal implant identified a prostate cancer metastasis, which responded well to hormonal therapy.

Prostate cancer metastasis to the testis: an unexpected presentation of a solitary recurrence

2021 ◽  
Vol 14 (3) ◽  
pp. e237853
Author(s):  
Conor McCann ◽  
Anna Doherty ◽  
Ciaran Flynn ◽  
Colin Mulholland
Keyword(s):  
Prostate Cancer ◽  
Cancer Metastasis ◽  
External Beam Radiotherapy ◽  
New Left ◽  
Specific Antigen ◽  
Metastatic Spread ◽  
Histopathological Analysis ◽  
Good Recovery ◽  
Prostate Cancer Metastasis ◽  
History Of

A 74-year-old man with a history of prostate cancer was referred to the urology team with a new left sided testicular lump. He had a background of prostate cancer 4 years previous which had been treated with external beam radiotherapy and androgen deprivation therapy, both of which had been completed. Concurrently, he also had evidence of biochemical recurrence of prostate cancer with a rising prostate-specific antigen (PSA). He underwent a left radical orchidectomy. Following histopathological analysis, this was found to be metastatic spread from his prostate cancer. Subsequent staging showed no evidence of metastatic spread elsewhere. The patient made a good recovery following surgery and his PSA levels returned to undetectable levels. He received no further treatment for metastatic prostate cancer.

scholarly journals Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Sun Shin ◽  
Yong Hyun Park ◽  
Seung-Hyun Jung ◽  
Sun-Hee Jang ◽  
Mee Young Kim ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Metastasis ◽  
Expression Profiles ◽  
Specific Antigen ◽  
Appropriate Treatment ◽  
Mirna Expression Profiles ◽  
Prostate Cancer Metastasis ◽  
Risk Scoring ◽  
Noninvasive Markers ◽  
Exosomal Mirna

AbstractPredicting the risk of metastasis before starting prostate cancer (PCa) treatment can minimize the overtreatment of indolent cases and help choosing appropriate treatment. The levels of circulating microRNAs (miRNAs) from body fluids can be used as noninvasive prognostic biomarkers. In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR-142-3p, miR-451, and miR-636. When evaluating clinical factors together, miR-21, miR-451, miR-636, and preoperative prostate-specific antigen (PSA) level remained significant in the multivariate analysis. Based on them, we developed a “Prostate Cancer Metastasis Risk Scoring (PCa-MRS)” model. The PCa-MRS showed superior stratification power (AUC = 0.925) to preoperative PSA or clinical Gleason score. Patients with high scores showed significantly poorer biochemical recurrence-free survival than those with low scores (P = 6.53 × 10−10). Our results showed the potential of urinary exosomal miRNAs as noninvasive markers for predicting metastasis and prognosis in PCa patients.

scholarly journals Metastatic prostate cancer with malignant ascites: A case report and literature review

2013 ◽  
Vol 7 (3-4) ◽  
pp. e248-50 ◽  
Author(s):  
Ifeanyi Ani ◽  
Mark Costaldi ◽  
Robert Abouassaly
Keyword(s):  
Prostate Cancer ◽  
Renal Failure ◽  
African American Male ◽  
Voiding Dysfunction ◽  
Specific Antigen ◽  
Malignant Ascites ◽  
Metabolic Abnormalities ◽  
Prostatic Specific Antigen ◽  
Urinary Tract Symptoms ◽  
Lower Urinary

Malignant ascites from advanced prostate cancer is a rare entity with only few cases reported. It represents a poor prognosis. We report a case of a 57 year old African American male presenting with weight loss, lower urinary tract symptoms, and voiding dysfunction, found to be in renal failure with metabolic abnormalities associated with significant abdominal distention and pain.  CT imaging showed ascites which was pathologically confirmed by immunostaining and cytological identification of malignant cells. Prostate biopsy identified high grade prostate cancer which responded to hormonal therapy with a significant decrease in serum prostatic specific antigen (PSA). Ascites was managed with paracentesis and renal failure with hemodialysis as needed.

scholarly journals Alveolar soft part sarcoma mimics prostate cancer metastasis

2019 ◽  
Vol 2019 (12) ◽  
pp. 507-509
Author(s):  
Daniel R Principe ◽  
Nisha A Mohindra ◽  
Hidayatullah G Munshi ◽  
Suneel D Kamath
Keyword(s):  
Prostate Cancer ◽  
Cancer Metastasis ◽  
Soft Part ◽  
Specific Antigen ◽  
Cancer Staging ◽  
Response To Therapy ◽  
Leg Pain ◽  
Alveolar Soft Part Sarcoma ◽  
Lung Lesions ◽  
Prostate Cancer Metastasis

Abstract A 61-year-old man presented to the oncology clinic with Gleason 9 (4 + 5) prostate cancer. Staging CT showed multiple nodules in both lungs. Since the lung lesions were too small for biopsy, he was started on anti-androgen therapy for suspected metastatic, hormone-sensitive prostate cancer. While his prostate-specific antigen decreased from 32 to <0.1 ng/ml, the multiple lung lesions showed no response on subsequent imaging. The patient presented during follow-up with severe right leg pain, at which time magnetic resonance imaging revealed a large, hyperintense mass in the femur. The mass was resected along with two lung nodules, with pathology demonstrating metastatic alveolar soft part sarcoma. This serves as an important reminder that lesions suspicious for metastases may be due to cancers of multiple primary origins, particularly if the pattern of metastasis is atypical or there is varied response to therapy.

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