scholarly journals Mediastinum Teratoma Rupture: A Rare Manifestation

2019 ◽  
Author(s):  
João Tavares ◽  
Bernardo Baptista ◽  
Bebiana Gonçalves ◽  
Pedro Raimundo ◽  
Henrique Vaz Velho ◽  
...  
Keyword(s):  
Mature Teratoma ◽  
Rare Event ◽  
Anterior Mediastinum ◽  
Pathological Examination ◽  
C Reactive Protein ◽  
Good Clinical Outcome ◽  
Reactive Protein ◽  
Left Upper Lobectomy ◽  
Rare Manifestation ◽  
Neutrophilic Leucocytosis

We present the case of a 22-year-old man who presented with cough, haemoptysis and fever of 3 days’ duration. A teratoma had been diagnosed 2 years previously. Physical examination was unremarkable but laboratory tests showed anaemia, neutrophilic leucocytosis and an increase in C-reactive protein. Chest CT revealed a teratoma of the anterior mediastinum with post-obstructive pneumonitis suggestive of tumour rupture. Antibiotic treatment resulted in a good clinical outcome. The patient was submitted to a left upper lobectomy and pathological examination revealed a mature teratoma. Teratomas are germ cell tumours that are usually asymptomatic and their rupture is a rare event.

scholarly journals 387. A Rare Manifestation of a Common Disease: Tenosynovitis Associated with Clostridium difficile: Case Report and Review of Literature

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S200-S200
Author(s):  
Greta M Josephson ◽  
Saira R Ajmal
Keyword(s):  
Clostridium Difficile ◽  
Reactive Arthritis ◽  
Streptococcal Pharyngitis ◽  
Common Disease ◽  
Review Of Literature ◽  
C Reactive Protein ◽  
Unique Case ◽  
Reactive Protein ◽  
Rare Manifestation ◽  
Severe Colitis

Abstract Background Reactive arthritis typically develops following enteric or genitourinary infection. The most common offending pathogens are Chlamydia, Salmonella, Shigella, Yersinia and Campylobacter. We report a unique case of a patient with tenosynovitis attributed to Clostridium difficile (C. difficile), and review of the literature. Methods We searched PubMed for “reactive arthritis” and “C. difficile” and found 53 cases. Two additional cases were excluded as they were published in French. Results An 18-year-old healthy male presented with nine days of abdominal pain and diarrhea, and two days of pain and swelling of bilateral fingers with an erythematous/ecchymotic rash over the second and third digits. Four weeks prior to symptom onset he received antibiotics for streptococcal pharyngitis. On presentation he had diffuse abdominal tenderness and edema of the PIP/DIP joints with tenderness throughout the phalangeal soft tissue, consistent with tenosynovitis. He had a leukocyte count of 33.0 thou/ μL and C-reactive protein of 12.0 mg/dL (normal < 1.0 mg/dL). C. difficile toxin PCR was positive, toxin EIA was negative. CT scan of the abdomen/pelvis demonstrated mural thickening consistent with extensive severe colitis. He received 14 days of oral vancomycin, with complete symptom resolution, including the tenosynovitis. Our literature review revealed 22.6% (12/53) of cases had involvement of hands, although all also had involvement of other joints. Our patient’s isolated tenosynovitis of bilateral hands is unique, and has only been reported once prior to our knowledge. Literature suggests treatment of the underlying C. difficile infection should result in rapid clinical improvement of tenosynovitis symptoms, as in our patient. Conclusion C. difficile continues to pose a significant threat to health and burden on the healthcare system. The association of reactive arthritis and C. difficile was first reported in 1976, with only 53 subsequent cases reported. Reactive arthritis classically presents as asymmetrical oligo- or polyarthritis involving lower extremities or large joints. Our case demonstrates isolated tenosynovitis of the hands may also be a possible presentation. Given the continued rise of C. difficile, it is imperative that this pathogen is considered in such cases. Disclosures All authors: No reported disclosures.

scholarly journals Correlation of calprotectin serum levels with degrees of endometriosis: A cross-sectional study

2021 ◽  
Author(s):  
Raden Muharam ◽  
Muhammad Saiful Rizal
Keyword(s):  
Inflammatory Diseases ◽  
Inflammatory Marker ◽  
Delayed Diagnosis ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Pathological Examination ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein

Background: Endometriosis is closely associated with delayed diagnosis due to the lack of a definitive and sensitive noninvasive approach. The use of calprotectin in inflammatory process has been demonstrated in various inflammatory diseases. Calprotectin has a significant correlation with high-sensitivity C-reactive protein (hs- CRP) and could be used as an inflammatory marker. No study thus far has evaluated the correlation between calprotectin and endometriosis. Objective: To determine the correlation of calprotectin with the degree of endometriosis in order to help clinicians in establishing better early detection and management. Materials and Methods: In this cross-sectional study, 46 women referred to the Cipto Mangunkusumo, Fatmawati, and Persahabatan Hospitals in Jakarta, Indonesia between July 2017 and April 2018 were enrolled, and their blood serum were taken a day before surgery. Calprotectin serum level was treated using the Phical® ELISA method. After the diagnosis of endometriosis was confirmed through pathological examination, the final diagnosis of endometriosis could be established. The degree of endometriosis was classified according to the revised American Society for Reproductive Medicine (ASRM) classification. Results: The prevalence of minimal, mild, moderate, and severe degrees of endometriosis were 15.2, 39.1, 34.8, and 10.9%, respectively. The median serum calprotectin levels for minimal, mild, moderate, and severe endometriosis were 138.98, 121.49, 124.16, and 122.82 mg/mL, respectively. No correlation was observed between calprotectin and the degrees of endometriosis (r = –0.16, p = 0.278). Conclusion: There is no correlation between calprotectin serum levels and the degrees of endometriosis. Key words: Calprotectin, Endometriosis, C-reactive protein, Inflammation.

scholarly journals Severe extensive community acquired aspergillus infection in a full‐term infant accompanied with increases in white blood cell counts and C-reactive protein: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yanli Wang ◽  
Wenjing Chen ◽  
Wenshen Wu ◽  
Dongling Yu ◽  
Huiheng Yan ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Fungal Infections ◽  
Full Term ◽  
Pathological Examination ◽  
C Reactive Protein ◽  
Term Neonates ◽  
Aspergillus Infection ◽  
Reactive Protein ◽  
Wbc Count

Abstract Background Aspergillus infection is more common among premature infants in neonatal intensive care units, who have decreased qualitative immune defenses and need various invasive treatment procedures. It is rare in normal full-term neonates, especially in newborn babies from the community. Moreover, the white blood cell (WBC) count and C-reactive protein (CRP) level may be normal or slightly changed in fungal infections, but the neonate reported in this study had significant increases in WBC and CRP. To the best of our knowledge, this is the first report on a full-term neonate from the community with aspergillus infection accompanied by significant increases in WBC and CRP levels. Case presentation A 28-day-old infant, who received empirical antibiotic treatment for 10 days because of neonatal pneumonia, was referred to our neonatal department from the local hospital. The infant had persistent infection and multiple organ failure syndromes. Bronchoscopy and deep sputum smear were performed to identify the pathogen, which confirmed aspergillus infection in the sputum. Fluconazole was immediately administered, but the baby died after three days. Thereafter, an autopsy was performed with parental consent. There were multiple necrotic areas in the lungs and liver, and pathological examination revealed aspergillus. Conclusions The present case emphasized that community-sourced aspergillus infection can exist in full-term neonates, with significantly increased WBC count and CRP level. Advanced antibiotics were not effective in this case, and fungal infections should have been considered earlier.

908: Preoperative C-Reactive Protein Elevation as a Predictor of Localized Renal Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 301-301
Author(s):  
Yasumasa Iimura ◽  
Kazutaka Saito ◽  
Minato Yokoyama ◽  
Hitoshi Masuda ◽  
Tsuyoshi Kobayashi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Localized Renal Cell Carcinoma
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