scholarly journals Fundic Gland Polyposis Associated with Proton-Pump Inhibitor Use

2017 ◽  
Vol 2 (LATEST ONLINE) ◽  
Author(s):  
Kenta Hamada ◽  
Yoji Takeuchi ◽  
Tomofumi Akasaka ◽  
Hiroyasu Iishi
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Fundic Gland ◽  
Fundic Gland Polyposis

Massive fundic gland polyposis caused by chronic proton pump inhibitor therapy

2012 ◽  
Vol 153 (9) ◽  
pp. 351-356 ◽  
Author(s):  
Ivett Hegedűs ◽  
Csaba Csizmadia ◽  
Zoltán Lomb ◽  
László Cseke ◽  
Yadamsuren Enkh-Amar ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Rare Complication ◽  
Proton Pump Inhibitor Therapy ◽  
Fundic Gland ◽  
Endoscopic Removal ◽  
Fundic Gland Polyps ◽  
First Case ◽  
Fundic Gland Polyposis ◽  
Enormous Number

We report two cases of a massive fundic gland polyposis associated with protracted proton pump inhibitor (PPI) therapy. Both patients were females aged 51. On repeated endoscopy, the number of fundic gland polyps was inreasing steeply, and they resulted in a passage disorder. In the first case, the enormous number of polyps made endoscopic removal impossible, so the patient was treated by total gastrectomy. Although our case is the second reported one in the world, we would like to draw the attention to this rare complication of long lasting PPI therapy. Orv. Hetil., 2012, 153, 351–356.

scholarly journals Prevalence of gastric polypoid lesions in a single endoscopic centre

2013 ◽  
Vol 154 (20) ◽  
pp. 770-774
Author(s):  
Ágnes Anna Csontos ◽  
Bálint Fekete ◽  
Katalin Lőrinczy ◽  
Orsolya Terjék ◽  
Lajos Berczi ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Chronic Gastritis ◽  
Malignant Lesion ◽  
Fundic Gland ◽  
Hyperplastic Polyps ◽  
Gastric Polyps ◽  
Fundic Gland Polyps ◽  
Upper Gastrointestinal

Background: The prevalence of gastric polyps is unknown in Hungary. Aim: The aim of the authors was to assess the prevalence of polypoid lesions of the stomach in the endoscopic centre of the 2nd Department of Medicine, Semmelweis University. Methods: Results of upper gastrointestinal endoscopies carried out between March 2010 and June 2011 were analysed. Results: 193 cases with polyps were diagnosed in 4174 endoscopies (4.62%). Hyperplastic polyps, fundic gland polyps and malignant lesion were detected in 33.67%, 31.09% and 2.07% of the cases, respectively. Proton pump inhibitor use was more frequent among patients diagnosed with fundus gland polyps (p = 0.007), while hyperplastic polyps were diagnosed more frequently in patients with chronic gastritis (p = 0.032). Conclusions: The frequency of gastric polyps was higher than expected from data published in the literature. Long-term proton pump-inhibitor use and chronic gastritis were associated with fundus gland and hyperplastic polyps, respectively. Orv. Hetil., 2013, 154, 770–774.

scholarly journals GASTRIC FUNDIC GLAND POLYPS: CAN HISTOLOGY BE USEFUL TO PREDICT PROTON PUMP INHIBITORS USE?

2018 ◽  
Vol 55 (4) ◽  
pp. 380-384
Author(s):  
Hugo Leite de Farias BRITO ◽  
Cynthia BARROS ◽  
Marcelle Vieira FREIRE ◽  
Miraldo Nascimento da SILVA FILHO ◽  
Tereza Virgínia NASCIMENTO
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump Inhibitors ◽  
Parietal Cell ◽  
Proton Pump ◽  
Proton Pump Inhibitor Therapy ◽  
Inhibitor Therapy ◽  
Fundic Gland ◽  
Acid Therapy ◽  
Fundic Gland Polyps ◽  
Two Samples

ABSTRACT BACKGROUND: Fundic gland polyps allegedly increased in frequency in recent decades, and had attracted great attention due to possible association with prolonged proton pump inhibitor therapy. Prolonged use of this drug could cause parietal cell hyperplasia, obstruction of glandular lumen and cystic dilation of the gland. OBJECTIVE: This study aims to analyze clinical and pathological features of fundic gland polyps in patients with and without proton pump inhibitor therapy in a selected population from Brazil. METHODS: It was selected a sample of 101 Brazilian patients (78 females and 23 males), from a five years retrospective search of the files from a private pathology laboratory. The patients had an average age of 57 years and we included patients with a histological diagnosis of fundic gland polyp. The clinical data were obtained from their files and all histological slides were reviewed and examined with hematoxylin and eosin (HE) and Giemsa. RESULTS: Information about the use or non-use of proton pump inhibitors (PPI) was obtained in 84 patient files. In 17 cases we could not determine if PPI were used or not. Among those in which the information was available, a positive history of anti-acid therapy was observed in 63 (75.0%) patients. Parietal cell hypertrophy/hyperplasia and parietal cell protrusions were detected in most slides. Histological findings were identical in PPI users and PPI negative patients. Helicobacter pylori infection was detected in just two samples. Epithelial dysplasia or adenocarcinoma were not observed in our cases. Histopathological analysis of fundic gland polyps could not distinguish between PPI and non-PPI related cases. Parietal cell cytoplasmic protrusions, an alleged marker of prolonged acid suppression therapy, was detected in both groups. CONCLUSION: Histological features could not discriminate anti-acid therapy related fundic glands polyps in our patients.

Chronic Proton Pump Inhibitor Therapy Increases Fundic Gland Polyps

2008 ◽  
Vol 103 ◽  
pp. S54 ◽  
Author(s):  
Mazer Ally ◽  
Ganesh Veerappan ◽  
Timothy Duncan ◽  
Joseph Perry ◽  
Corinne Maydonovitch ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Proton Pump Inhibitor Therapy ◽  
Inhibitor Therapy ◽  
Fundic Gland ◽  
Fundic Gland Polyps
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