scholarly journals Organization and Evolution of the Cyp2 Gene Cluster on Mouse Chromosome 7, and Comparison with the Syntenic Human Cluster*

2008 ◽  
Author(s):  
Haoyi Wang ◽  
Kyle M. Donley ◽  
Diane S. Keeney ◽  
Susan M.G. Hoffman
Keyword(s):  
Gene Cluster ◽  
Mouse Chromosome ◽  
Chromosome 7

scholarly journals Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.

2003 ◽  
Vol 111 (15) ◽  
pp. 1835-1842 ◽  
Author(s):  
Haoyi Wang ◽  
Kyle M Donley ◽  
Diane S Keeney ◽  
Susan M G Hoffman
Keyword(s):  
Gene Cluster ◽  
Mouse Chromosome ◽  
Chromosome 7

Comparative Analysis of a Conserved Zinc Finger Gene Cluster on Human Chromosome 19q and Mouse Chromosome 7

Genomics ◽  
1996 ◽  
Vol 33 (1) ◽  
pp. 112-120 ◽  
Author(s):  
Mark Shannon ◽  
Linda K. Ashworth ◽  
Michael L. Mucenski ◽  
Jane E. Lamerdin ◽  
Elbert Branscomb ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Human Chromosome ◽  
Gene Cluster ◽  
Mouse Chromosome ◽  
Zinc Finger ◽  
Chromosome 7 ◽  
Zinc Finger Gene ◽  
Chromosome 19Q

Mouse Chromosome 7

1999 ◽  
Vol 10 (10) ◽  
pp. 947-947 ◽  
Author(s):  
Robert W. Williams ◽  
Joe M. Angel ◽  
Bernadette C. Holdener ◽  
Rebecca Oakey ◽  
Kent W. Hunter
Keyword(s):  
Mouse Chromosome ◽  
Chromosome 7

scholarly journals The H19 Differentially Methylated Region Marks the Parental Origin of a Heterologous Locus without Gametic DNA Methylation

2004 ◽  
Vol 24 (9) ◽  
pp. 3588-3595 ◽  
Author(s):  
Kye-Yoon Park ◽  
Elizabeth A. Sellars ◽  
Alexander Grinberg ◽  
Sing-Ping Huang ◽  
Karl Pfeifer
Keyword(s):  
Dna Methylation ◽  
Mouse Chromosome ◽  
Germ Line ◽  
Transcriptional Silencing ◽  
Chromosome 7 ◽  
Differentially Methylated Region ◽  
Parental Origin ◽  
Imprinted Genes ◽  
Chromosome 5 ◽  
The Third

ABSTRACT Igf2 and H19 are coordinately regulated imprinted genes physically linked on the distal end of mouse chromosome 7. Genetic analyses demonstrate that the differentially methylated region (DMR) upstream of the H19 gene is necessary for three distinct functions: transcriptional insulation of the maternal Igf2 allele, transcriptional silencing of paternal H19 allele, and marking of the parental origin of the two chromosomes. To test the sufficiency of the DMR for the third function, we inserted DMR at two heterologous positions in the genome, downstream of H19 and at the alpha-fetoprotein locus on chromosome 5. Our results demonstrate that the DMR alone is sufficient to act as a mark of parental origin. Moreover, this activity is not dependent on germ line differences in DMR methylation. Thus, the DMR can mark its parental origin by a mechanism independent of its own DNA methylation.

The albino-deletion complex in the mouse defines genes necessary for development of embryonic and extraembryonic ectoderm

Development ◽  
1989 ◽  
Vol 105 (1) ◽  
pp. 175-182 ◽  
Author(s):  
L. Niswander ◽  
D. Yee ◽  
E.M. Rinchik ◽  
L.B. Russell ◽  
T. Magnuson
Keyword(s):  
Mouse Chromosome ◽  
Primitive Streak ◽  
Chromosome 7 ◽  
Complementation Analysis ◽  
Lethal Phenotype ◽  
Neural Axis ◽  
Embryological Analysis ◽  
Compound Heterozygotes

A detailed embryological analysis has been undertaken on embryos carrying the c4FR60Hd-, c5FR60Hg- or c2YPSj-albino deletions of mouse chromosome 7. Embryos homozygous for the c4FR60Hd deletion are abnormal at day 7.5 of gestation. The extraembryonic ectoderm does not develop, and primitive-streak formation and mesoderm production do not occur. In contrast, extensive development of the extraembryonic ectoderm, as well as mesoderm production, are observed in the c5FR60Hg- and c2YPSj-homozygous embryos. The mesoderm does not, however, organize into somites and the neural axis does not form. The embryos are grossly abnormal by day 8.5 of development. There are two other albino deletions (c6H and c11DSD) that are known to affect the embryo around the time of gastrulation (Niswander et al. 1988), and the lethal phenotype observed for the c4FR60Hd-homozygous embryos is similar to that described for c6H-homozygous embryos, whereas the c5FR60Hg- and c2YPSj-homozygous embryos display a phenotype that is similar to c11DSD-homozygous embryos. A detailed complementation analysis using these five deletions revealed that the c5FR60Hg, c2YPSj and c11DSD deletions could partially complement the phenotype produced by the c4FR60Hd and c6H deletions in any combination. Extensive development of the extraembryonic structures and production of mesoderm occurs in the compound heterozygotes. These results suggest that the distal breakpoints of the c5FR60Hg, c2YPSj and c11DSD deletions lie more proximal than the distal breakpoints of the c4FR60Hd and c6H deletions.(ABSTRACT TRUNCATED AT 250 WORDS)

A gene-anchored map position of the rat warfarin-resistance locus, Rw, and its orthologs in mice and humans

Blood ◽  
2000 ◽  
Vol 96 (5) ◽  
pp. 1996-1998 ◽  
Author(s):  
Michael H. Kohn ◽  
Hans-Joachim Pelz
Keyword(s):  
Linkage Analysis ◽  
Mouse Chromosome ◽  
Microsatellite Loci ◽  
Laboratory Strain ◽  
Chromosome 7 ◽  
Resistance Locus ◽  
Human Chromosomes ◽  
Genome Maps ◽  
Warfarin Resistance

Abstract The locus underlying hereditary resistance to the anticoagulant warfarin (symbol in the rat, Rw) was placed in relation to 8 positionally mapped gene-anchored microsatellite loci whose positions were known in the genome maps of the rat, mouse, and human.Rw segregated with the markers Myl2 (zero recombinants) and Itgam, Il4r, andFgf2r (one recombinant each) during linkage analysis in a congenic warfarin- and bromadiolone-resistant laboratory strain of rats. Comparative ortholog mapping between rat, mouse, and human placedRw onto mouse chromosome 7 at about 60 to 63 cM and onto one of the human chromosomes 10q25.3-26, 12q23-q24.3, and 16p13.1-p11.

Assignment of the gene for lactic dehydrogenase A to mouse chromosome 7 using mouse-human hybrids

1978 ◽  
Vol 21 (1-2) ◽  
pp. 72-76 ◽  
Author(s):  
D. O’Brien ◽  
A. Linnenbach ◽  
C.M. Croce
Keyword(s):  
Mouse Chromosome ◽  
Lactic Dehydrogenase ◽  
Chromosome 7
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