Air pollution and temperature on associations with DNA methylation in a mother-child cohort: an epigenome-wide analysis using penalization methods.

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Emilie Abraham* ◽  
Marie-Abèle Bind ◽  
Lise Giorgis-Allemand ◽  
Jorg Tost ◽  
Julien Galineau ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Air Pollution ◽  
Penalization Methods

Epigenome-wide analysis of long-term air pollution exposure and DNA methylation in monocytes: results from the Multi-Ethnic Study of Atherosclerosis

Epigenetics ◽  
2021 ◽  
pp. 1-17
Author(s):  
Gloria C. Chi ◽  
Yongmei Liu ◽  
James W. MacDonald ◽  
Lindsay M. Reynolds ◽  
Daniel A. Enquobahrie ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Air Pollution ◽  
Ethnic Study ◽  
Air Pollution Exposure ◽  
Pollution Exposure

scholarly journals Early Pregnancy Exposure to Ambient Air Pollution among Late-Onset Preeclamptic Cases Is Associated with Placental DNA Hypomethylation of Specific Genes and Slower Placental Maturation

Toxics ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 338
Author(s):  
Karin Engström ◽  
Yumjirmaa Mandakh ◽  
Lana Garmire ◽  
Zahra Masoumi ◽  
Christina Isaxon ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Air Pollution ◽  
Early Pregnancy ◽  
Late Onset ◽  
Dispersion Model ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Dna Hypomethylation ◽  
Increased Risk

Exposure to ambient air pollution during pregnancy has been associated with an increased risk of preeclampsia (PE). Some suggested mechanisms behind this association are changes in placental DNA methylation and gene expression. The objective of this study was to identify how early pregnancy exposure to ambient nitrogen oxides (NOx) among PE cases and normotensive controls influence DNA methylation (EPIC array) and gene expression (RNA-seq). The study included placentas from 111 women (29 PE cases/82 controls) in Scania, Sweden. First-trimester NOx exposure was assessed at the participants’ residence using a dispersion model and categorized via median split into high or low NOx. Placental gestational epigenetic age was derived from the DNA methylation data. We identified six differentially methylated positions (DMPs, q < 0.05) comparing controls with low NOx vs. cases with high NOx and 14 DMPs comparing cases and controls with high NOx. Placentas with female fetuses showed more DMPs (N = 309) than male-derived placentas (N = 1). Placentas from PE cases with high NOx demonstrated gestational age deceleration compared to controls with low NOx (p = 0.034). No differentially expressed genes (DEGs, q < 0.05) were found. In conclusion, early pregnancy exposure to NOx affected placental DNA methylation in PE, resulting in placental immaturity and showing sexual dimorphism.

Characteristics of DNA methylation changes induced by traffic-related air pollution

2016 ◽  
Vol 796 ◽  
pp. 46-53 ◽  
Author(s):  
Rui Ding ◽  
Yongtang Jin ◽  
Xinneng Liu ◽  
Ziyi Zhu ◽  
Yuan Zhang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Air Pollution

scholarly journals Air pollution and DNA methylation: effects of exposure in humans

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Christopher F. Rider ◽  
Chris Carlsten
Keyword(s):  
Dna Methylation ◽  
Air Pollution

Long-Term Outdoor Air Pollution and ‘Global’ DNA Methylation in Circulating Monocytes

2014 ◽  
Vol 2014 (1) ◽  
pp. 2680 ◽  
Author(s):  
Gloria Chi* ◽  
Yongmei Liu ◽  
James MacDonald ◽  
R. Graham Barr ◽  
Kathleen Donohue ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Air Pollution ◽  
Global Dna Methylation ◽  
Outdoor Air ◽  
Outdoor Air Pollution

Epigenome-Wide Meta-Analysis of DNA Methylation in Children related to Prenatal Particulate Air Pollution Exposure

2018 ◽  
Vol 2017 (1) ◽  
pp. 172
Author(s):  
Olena Gruzieva ◽  
Carrie V. Breton ◽  
Herman T. den Dekker ◽  
Akram Ghantous ◽  
Allan C. Just ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Air Pollution ◽  
Meta Analysis ◽  
Particulate Air Pollution ◽  
Air Pollution Exposure ◽  
Pollution Exposure

Prolonged Exposure to Particulate Air Pollution and Decreased DNA Methylation

Epidemiology ◽  
2009 ◽  
Vol 20 ◽  
pp. S45
Author(s):  
Jaime Madrigano ◽  
Andrea Baccarelli ◽  
Pantel Vokonas ◽  
Helen Suh ◽  
Valentina Bollati ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Air Pollution ◽  
Prolonged Exposure ◽  
Particulate Air Pollution
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