Impact of phthalate exposure during early, mid, and late in utero development in relation to ADHD symptoms at 6-11 years of age

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Deborah J. Watkins* ◽  
John D. Meeker ◽  
Lourdes Schnaas ◽  
Maritsa Solano-Gonzalez ◽  
Erika Osorio-Valencia ◽  
...  
Keyword(s):  
In Utero ◽  
Adhd Symptoms ◽  
Phthalate Exposure ◽  
In Utero Development

scholarly journals Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair

2014 ◽  
Vol 42 (15) ◽  
pp. 9807-9820 ◽  
Author(s):  
Meghan Larin ◽  
David Gallo ◽  
Laura Tamblyn ◽  
Jay Yang ◽  
Hudson Liao ◽  
...  
Keyword(s):  
Dna Damage ◽  
Fanconi Anemia ◽  
Congenital Abnormalities ◽  
Bone Marrow Failure ◽  
In Utero ◽  
Critical Threshold ◽  
Growth Defects ◽  
Repair Defect ◽  
In Utero Development ◽  
Crosslink Repair

AbstractIndividuals with Fanconi anemia (FA) are susceptible to bone marrow failure, congenital abnormalities, cancer predisposition and exhibit defective DNA crosslink repair. The relationship of this repair defect to disease traits remains unclear, given that crosslink sensitivity is recapitulated in FA mouse models without most of the other disease-related features. Mice deficient in Mus81 are also defective in crosslink repair, yet MUS81 mutations have not been linked to FA. Using mice deficient in both Mus81 and the FA pathway protein FancC, we show both proteins cooperate in parallel pathways, as concomitant loss of FancC and Mus81 triggered cell-type-specific proliferation arrest, apoptosis and DNA damage accumulation in utero. Mice deficient in both FancC and Mus81 that survived to birth exhibited growth defects and an increased incidence of congenital abnormalities. This cooperativity of FancC and Mus81 in developmental outcome was also mirrored in response to crosslink damage and chromosomal integrity. Thus, our findings reveal that both pathways safeguard against DNA damage from exceeding a critical threshold that triggers proliferation arrest and apoptosis, leading to compromised in utero development.

Impact of pathogenic PPARG variants on pregnancy outcomes and in utero development

Placenta ◽  
2021 ◽  
Vol 112 ◽  
pp. e73-e74
Author(s):  
Camille Gosseaume ◽  
Thierry Fournier ◽  
Isabelle Jeru ◽  
Isabelle Missotte ◽  
Catherine Pienkowski ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
In Utero ◽  
In Utero Development

scholarly journals In Utero Development of the Fetal Gall Bladder in the Korean Population

2008 ◽  
Vol 9 (1) ◽  
pp. 54 ◽  
Author(s):  
Min Hoan Moon ◽  
Jeong Yeon Cho ◽  
Ju Hee Kim ◽  
Young Ho Lee ◽  
Sung Il Jung ◽  
...  
Keyword(s):  
Gall Bladder ◽  
In Utero ◽  
Korean Population ◽  
In Utero Development

scholarly journals Impact of prenatal maternal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later

2021 ◽  
Vol 118 (15) ◽  
pp. e2014464118
Author(s):  
Jill M. Goldstein ◽  
Justine E. Cohen ◽  
Klara Mareckova ◽  
Laura Holsen ◽  
Susan Whitfield-Gabrieli ◽  
...  
Keyword(s):  
Sex Differences ◽  
Functional Connectivity ◽  
Proinflammatory Cytokines ◽  
Brain Activity ◽  
In Utero ◽  
Anterior Cingulate ◽  
Hippocampal Activity ◽  
Brain Circuitry ◽  
Anti Inflammatory ◽  
In Utero Development

Stress is associated with numerous chronic diseases, beginning in fetal development with in utero exposures (prenatal stress) impacting offspring’s risk for disorders later in life. In previous studies, we demonstrated adverse maternal in utero immune activity on sex differences in offspring neurodevelopment at age seven and adult risk for major depression and psychoses. Here, we hypothesized that in utero exposure to maternal proinflammatory cytokines has sex-dependent effects on specific brain circuitry regulating stress and immune function in the offspring that are retained across the lifespan. Using a unique prenatal cohort, we tested this hypothesis in 80 adult offspring, equally divided by sex, followed from in utero development to midlife. Functional MRI results showed that exposure to proinflammatory cytokines in utero was significantly associated with sex differences in brain activity and connectivity during response to negative stressful stimuli 45 y later. Lower maternal TNF-α levels were significantly associated with higher hypothalamic activity in both sexes and higher functional connectivity between hypothalamus and anterior cingulate only in men. Higher prenatal levels of IL-6 were significantly associated with higher hippocampal activity in women alone. When examined in relation to the anti-inflammatory effects of IL-10, the ratio TNF-α:IL-10 was associated with sex-dependent effects on hippocampal activity and functional connectivity with the hypothalamus. Collectively, results suggested that adverse levels of maternal in utero proinflammatory cytokines and the balance of pro- to anti-inflammatory cytokines impact brain development of offspring in a sexually dimorphic manner that persists across the lifespan.

Beta-cell β1 integrin deficiency affects in utero development of islet growth and vascularization

2020 ◽  
Vol 381 (1) ◽  
pp. 163-175
Author(s):  
Phyo Wei Win ◽  
Amanda Oakie ◽  
Jinming Li ◽  
Rennian Wang
Keyword(s):  
Beta Cell ◽  
In Utero ◽  
Β1 Integrin ◽  
In Utero Development

scholarly journals Associations between in utero phthalate exposure and non-nutritive suck

2019 ◽  
Vol 3 ◽  
pp. 428-429
Author(s):  
Watkins D ◽  
Zimmerman E ◽  
Manjourides J ◽  
Hines M ◽  
Huerta-Montañez G ◽  
...  
Keyword(s):  
In Utero ◽  
Phthalate Exposure
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