Integrating air pollution exposure in a mechanistic agent-based model of asthma: Model development and application to childhood asthma outcomes

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Ayaz Hyder*
Keyword(s):  
Air Pollution ◽  
Childhood Asthma ◽  
Model Development ◽  
Agent Based Model ◽  
Agent Based ◽  
Asthma Model ◽  
Air Pollution Exposure ◽  
Asthma Outcomes ◽  
Pollution Exposure

scholarly journals Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up

2017 ◽  
Vol 195 (10) ◽  
pp. 1373-1383 ◽  
Author(s):  
Anna Gref ◽  
Simon K. Merid ◽  
Olena Gruzieva ◽  
Stéphane Ballereau ◽  
Allan Becker ◽  
...  
Keyword(s):  
Air Pollution ◽  
Childhood Asthma ◽  
Interaction Analysis ◽  
Genome Wide ◽  
Air Pollution Exposure ◽  
Pollution Exposure

scholarly journals A multicentre study of air pollution exposure and childhood asthma prevalence: the ESCAPE project

2014 ◽  
Vol 45 (3) ◽  
pp. 610-624 ◽  
Author(s):  
Anna Mölter ◽  
Angela Simpson ◽  
Dietrich Berdel ◽  
Bert Brunekreef ◽  
Adnan Custovic ◽  
...  
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Nitrogen Dioxide ◽  
Childhood Asthma ◽  
Sensitivity Analyses ◽  
Asthma Prevalence ◽  
Birth Cohorts ◽  
Air Pollution Exposure ◽  
Meta Analyses ◽  
Pollution Exposure

The aim of this study was to determine the effect of six traffic-related air pollution metrics (nitrogen dioxide, nitrogen oxides, particulate matter with an aerodynamic diameter <10 μm (PM10), PM2.5, coarse particulate matter and PM2.5 absorbance) on childhood asthma and wheeze prevalence in five European birth cohorts: MAAS (England, UK), BAMSE (Sweden), PIAMA (the Netherlands), GINI and LISA (both Germany, divided into north and south areas).Land-use regression models were developed for each study area and used to estimate outdoor air pollution exposure at the home address of each child. Information on asthma and current wheeze prevalence at the ages of 4–5 and 8–10 years was collected using validated questionnaires. Multiple logistic regression was used to analyse the association between pollutant exposure and asthma within each cohort. Random-effects meta-analyses were used to combine effect estimates from individual cohorts.The meta-analyses showed no significant association between asthma prevalence and air pollution exposure (e.g. adjusted OR (95%CI) for asthma at age 8–10 years and exposure at the birth address (n=10377): 1.10 (0.81–1.49) per 10 μg·m-3 nitrogen dioxide; 0.88 (0.63–1.24) per 10 μg·m-3 PM10; 1.23 (0.78–1.95) per 5 μg·m-3 PM2.5). This result was consistently found in initial crude models, adjusted models and further sensitivity analyses.This study found no significant association between air pollution exposure and childhood asthma prevalence in five European birth cohorts.

scholarly journals The MEDEA childhood asthma study design for mitigation of desert dust health effects: implementation of novel methods for assessment of air pollution exposure and lessons learned

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Panayiotis Kouis ◽  
Stefania I. Papatheodorou ◽  
Maria G. Kakkoura ◽  
Nicos Middleton ◽  
Emmanuel Galanakis ◽  
...  
Keyword(s):  
Air Pollution ◽  
Clinical Outcomes ◽  
Health Effects ◽  
Childhood Asthma ◽  
Primary Schools ◽  
Desert Dust ◽  
Exposure Reduction ◽  
Air Pollution Exposure ◽  
Dust Events ◽  
Pollution Exposure

Abstract Background Desert dust events in Mediterranean countries, originating mostly from the Sahara and Arabian deserts, have been linked to climate change and are associated with significant increase in mortality and hospital admissions from respiratory causes. The MEDEA clinical intervention study in children with asthma is funded by EU LIFE+ program to evaluate the efficacy of recommendations aiming to reduce exposure to desert dust and related health effects. Methods This paper describes the design, methods, and challenges of the MEDEA childhood asthma study, which is performed in two highly exposed regions of the Eastern Mediterranean: Cyprus and Greece-Crete. Eligible children are recruited using screening surveys performed at primary schools and are randomized to three parallel intervention groups: a) no intervention for desert dust events, b) interventions for outdoor exposure reduction, and c) interventions for both outdoor and indoor exposure reduction. At baseline visits, participants are enrolled on MEDena® Health-Hub, which communicates, alerts and provides exposure reduction recommendations in anticipation of desert dust events. MEDEA employs novel environmental epidemiology and telemedicine methods including wearable GPS, actigraphy, health parameters sensors as well as indoor and outdoor air pollution samplers to assess study participants’ compliance to recommendations, air pollutant exposures in homes and schools, and disease related clinical outcomes. Discussion The MEDEA study evaluates, for the first time, interventions aiming to reduce desert dust exposure and implement novel telemedicine methods in assessing clinical outcomes and personal compliance to recommendations. In Cyprus and Crete, during the first study period (February–May 2019), a total of 91 children participated in the trial while for the second study period (February–May 2020), another 120 children completed data collection. Recruitment for the third study period (February–May 2021) is underway. In this paper, we also present the unique challenges faced during the implementation of novel methodologies to reduce air pollution exposure in children. Engagement of families of asthmatic children, schools and local communities, is critical. Successful study completion will provide the knowledge for informed decision-making both at national and international level for mitigating the health effects of desert dust events in South-Eastern Europe. Trial registration ClinicalTrials.gov: NCT03503812, April 20, 2018.

scholarly journals On-road Air Pollution Exposure to Cyclists in an Agent-Based Simulation Framework

2019 ◽  
Vol 48 (2) ◽  
pp. 117-125
Author(s):  
Amit Agarwal ◽  
Ihab Kaddoura
Keyword(s):  
Air Pollution ◽  
Major Effect ◽  
Background Concentration ◽  
Exposure Level ◽  
Simulation Framework ◽  
Agent Based Simulation ◽  
Agent Based ◽  
Air Pollution Exposure ◽  
Mode Of Transport ◽  
Pollution Exposure

Bicycle is not only a sustainable mode of transport but also health benefits of bicycling due to increased physical activities are well cited. However, in urban agglomerations, on-road air pollution exposure to cyclists/pedestrians is a matter of concern which is understudied. This study proposes an approach to calculate the on-road air pollution exposure for drivers of different vehicles in an agent-based simulation framework. In the proposed approach, the breathing rate of different drivers, penetration rate, vehicle-occupancy and background concentration are taken into consideration. The approach is applied to a real-world scenario of Patna, India where non-motorized modes are in abundance. A comparison of total inhaled mass per trip for drivers of different vehicles is made and it is found that cyclists are most exposed user group. An analysis for various background concentrations for different days of the year shows that the contribution of the background concentration has a major effect on the air pollution exposure level. The outcome is spatially analyzed to identify the locations of most affected user groups mapped to their home locations. Further, the on-road air pollution exposure of business-as-usual scenario is compared with a policy case and it is found that a dedicated bicycle track can increase the exposure per trip to cyclists by 40 %.

Effect of Ambient Air pollution Exposure on Development of Childhood Asthma

Epidemiology ◽  
2007 ◽  
Vol 18 (Suppl) ◽  
pp. S180-S181 ◽  
Author(s):  
N Clark ◽  
P Demers ◽  
C Karr ◽  
M Koehoorn ◽  
L Tamburic ◽  
...  
Keyword(s):  
Air Pollution ◽  
Childhood Asthma ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Air Pollution Exposure ◽  
Pollution Exposure

scholarly journals Current pet ownership modifies the adverse association between long‐term ambient air pollution exposure and childhood asthma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiao‐Wen Zeng ◽  
Caroline J. Lodge ◽  
Adrian J. Lowe ◽  
Yuming Guo ◽  
Michael J. Abramson ◽  
...  
Keyword(s):  
Air Pollution ◽  
Childhood Asthma ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Pet Ownership ◽  
Air Pollution Exposure ◽  
Pollution Exposure
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