Association of Urine Zinc with Prevalent and Incident Diabetes in the Strong Heart Study

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Martha Powers* ◽  
Nisa Marathur ◽  
Barbara V Howard ◽  
Jason G Umans ◽  
Elisa T Lee ◽  
...  
Keyword(s):  
Incident Diabetes ◽  
Strong Heart Study ◽  
Heart Study ◽  
Urine Zinc

scholarly journals Physical Activity and Incident Diabetes in American Indians: The Strong Heart Study

2009 ◽  
Vol 170 (5) ◽  
pp. 632-639 ◽  
Author(s):  
A. M. Fretts ◽  
B. V. Howard ◽  
A. M. Kriska ◽  
N. L. Smith ◽  
T. Lumley ◽  
...  
Keyword(s):  
Physical Activity ◽  
American Indians ◽  
Incident Diabetes ◽  
Strong Heart Study ◽  
Heart Study

scholarly journals Arsenic Exposure, Arsenic Metabolism, and Incident Diabetes in the Strong Heart Study

Diabetes Care ◽  
2015 ◽  
pp. dc141641 ◽  
Author(s):  
Chin-Chi Kuo ◽  
Barbara V. Howard ◽  
Jason G. Umans ◽  
Matthew O. Gribble ◽  
Lyle G. Best ◽  
...  
Keyword(s):  
Arsenic Exposure ◽  
Incident Diabetes ◽  
Arsenic Metabolism ◽  
Strong Heart Study ◽  
Heart Study

Arsenic Exposure, Arsenic Metabolism, and Incident Diabetes in the Strong Heart Study

2014 ◽  
Vol 2014 (1) ◽  
pp. 2921
Author(s):  
Barbara V Howard ◽  
Jason G. Umans ◽  
Matthew O Gribble ◽  
Lyle Best ◽  
Kevin A Francesconi ◽  
...  
Keyword(s):  
Arsenic Exposure ◽  
Incident Diabetes ◽  
Arsenic Metabolism ◽  
Strong Heart Study ◽  
Heart Study

scholarly journals Plasma Ceramide Species Are Associated with Diabetes Risk in Participants of the Strong Heart Study

2019 ◽  
Vol 150 (5) ◽  
pp. 1214-1222 ◽  
Author(s):  
Amanda M Fretts ◽  
Paul N Jensen ◽  
Andrew Hoofnagle ◽  
Barbara McKnight ◽  
Barbara V Howard ◽  
...  
Keyword(s):  
American Indian ◽  
Multiple Testing ◽  
Meta Analysis ◽  
Arachidic Acid ◽  
Behenic Acid ◽  
Diabetes Risk ◽  
Incident Diabetes ◽  
Survival Models ◽  
Strong Heart Study ◽  
Heart Study

ABSTRACT Background Few studies have assessed the associations of ceramides and sphingomyelins (SMs) with diabetes in humans. Objective We assessed associations of 15 circulating ceramides and SM species with incident diabetes in 2 studies. Methods The analysis included 435 American-Indian participants from the Strong Heart Study (nested case-control design for analyses; mean age: 57 y; 34% male; median time until diabetes 4.3 y for cases) and 1902 participants from the Strong Heart Family Study (prospective design for analyses; mean age: 37 y; 39% male; median 12.5 y of follow-up). Sphingolipid species were measured using stored plasma samples by sequential LC and MS. Using logistic regression and parametric survival models within studies, and an inverse-variance-weighted meta-analysis across studies, we examined associations of 15 ceramides and SM species with incident diabetes. Results There were 446 cases of incident diabetes across the studies. Higher circulating concentrations of ceramides containing stearic acid (Cer-18), arachidic acid (Cer-20), and behenic acid (Cer-22) were each associated with a higher risk of diabetes. The RRs for incident diabetes per 1 SD of each log ceramide species (μM) were 1.22 (95% CI: 1.09, 1.37) for Cer-18, 1.18 (95% CI: 1.06, 1.31) for Cer-20, and 1.20 (95% CI: 1.08, 1.32) for Cer-22. Although the magnitude of the risk estimates for the association of ceramides containing lignoceric acid (Cer-24) with diabetes was similar to those for Cer-18, Cer-20, and Cer-22 (RR = 1.13; 95% CI: 1.01, 1.26), the association was not statistically significant after correction for multiple testing (P = 0.007). Ceramides carrying palmitic acid (Cer-16), SMs, glucosyl-ceramides, or a lactosyl-ceramide were not associated with diabetes risk. Conclusions Higher concentrations of circulating Cer-18, Cer-20, and Cer-22 were associated with a higher risk of developing diabetes in 2 studies of American-Indian adults. This trial was registered at clinicaltrials.gov as NCT00005134.

scholarly journals Quantitative assessment of electrocardiographic strain predicts increased left ventricular mass: the strong heart study

2002 ◽  
Vol 40 (8) ◽  
pp. 1395-1400 ◽  
Author(s):  
Peter M Okin ◽  
Richard B Devereux ◽  
Richard R Fabsitz ◽  
Elisa T Lee ◽  
James M Galloway ◽  
...  
Keyword(s):  
Left Ventricular Mass ◽  
Quantitative Assessment ◽  
Left Ventricular ◽  
Strong Heart Study ◽  
Ventricular Mass ◽  
Heart Study
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