Survival analysis with measurement error in a cumulative exposure variable: radon progeny in relation to lung cancer mortality

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Donna Spiegelman* ◽  
Polyna Khudyakov ◽  
Jonathan Samet ◽  
Charles Wiggins ◽  
Xiaomei Liao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Survival Analysis ◽  
Measurement Error ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
Cumulative Exposure ◽  
Radon Progeny ◽  
Exposure Variable

BIER IV Committee Estimates of Lung Cancer Mortality Associated with Exposure to Radon Progeny

1988 ◽  
Vol 24 (1-4) ◽  
pp. 445-449
Author(s):  
W.H. Ellett ◽  
J.I. Fabrikant ◽  
R.D. Cooper (INVITED)
Keyword(s):  
Lung Cancer ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
Radon Progeny

scholarly journals Lung cancer mortality in the French cohort of titanium dioxide workers: some aetiological insights

2020 ◽  
Vol 77 (11) ◽  
pp. 795-797
Author(s):  
Irina Guseva Canu ◽  
Alan Gaillen-Guedy ◽  
Pascal Wild ◽  
Kurt Straif ◽  
Danièle Luce
Keyword(s):  
Lung Cancer ◽  
Titanium Dioxide ◽  
Cancer Mortality ◽  
Cox Regression ◽  
Lung Cancer Mortality ◽  
Cumulative Exposure ◽  
Current Evidence ◽  
Categorical Variables ◽  
Exposure Limits ◽  
Annual Average

ObjectivesTitanium dioxide (TiO2) is widely used in construction, food, cosmetic and medical industry. The current evidence on TiO2 carcinogenicity in humans is considered inadequate. As French participants of the European cohort of TiO2 workers exhibited an increase in mortality from lung cancer, we aimed at investigating whether TiO2 exposure, co-exposures or smoking can explain this increase.MethodsWe reanalysed the data of 833 French male workers (follow-up period 1968–1997) and used multiple imputation to complete their smoking status. We considered respirable TiO2 dust as primary exposure of interest, estimated as continuous cumulative (mg/m3-year) and annual average (mg/m3) concentrations and binary and 4-class categorical variables, with cut-off values of 0.3 and 2.4 mg/m3 (the German and American occupational exposure limits, respectively). For each exposure metric, we estimated HRs and associated 95% CIs, using Cox regression models adjusted for calendar period, exposure duration and smoking.ResultsThe fully adjusted model yielded a HR=3.7 (95% CI=0.79 to 17.95) for TiO2-exposed workers vs unexposed and a HR=27.33 (95% CI=4.35 to 171.84) for those exposed to >2.4 mg/m3 as annual average concentration. Employment duration was negatively related with lung cancer mortality, therefore cumulative exposure had a small effect on mortality (HR=1.03 (95% CI=0.99 to 1.08) per mg/m3-year).ConclusionThis study suggests a positive relationship between TiO2 exposure and lung cancer mortality in TiO2 workers, whatever the exposure variable used, despite a limited statistical power in some models. The results question the current evidence on TiO2 carcinogenicity in humans but need to be confirmed in other cohorts, using different statistical approaches.

CONTRIBUTION OF RADON PROGENY TO TOTAL LUNG DOSE AND ITS RELATION WITH LUNG CANCER MORTALITY AMONG FRENCH URANIUM MINERS

2011 ◽  
Vol 2011 (1) ◽  
Author(s):  
Estelle Rage ◽  
Blandine Vacquier ◽  
Eric Blanchardon ◽  
Rodrigue S. Allodji ◽  
James Marsh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
Radon Progeny ◽  
Lung Dose ◽  
Uranium Miners

Lung Cancer Mortality and Exposure to Radon Progeny in a Cohort of New Mexico Underground Uranium Miners

1991 ◽  
Vol 61 (6) ◽  
pp. 745-752 ◽  
Author(s):  
Jonathan M. Samet ◽  
Dorothy R. Pathak ◽  
Marion V. Morgan ◽  
Jay H. Lubin ◽  
Arnolfo A. Valdivia ◽  
...  
Keyword(s):  
Lung Cancer ◽  
New Mexico ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
Radon Progeny ◽  
Uranium Miners
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