DOES COMMUNITY VULNERABILITY AMPLIFY THE RELATIONSHIP BETWEEN TRAFFIC EXPOSURE AND ADVERSE BIRTH OUTCOMES? A UNIVERSITY-REGULATORY RESEARCH COLLABORATIVE ON ENVIRONMENTAL HEALTH INEQUALITIES

2011 ◽  
Vol 2011 (1) ◽  
Author(s):  
Rachel Morello-Frosch ◽  
Bill Jesdale ◽  
Paul English ◽  
Manuel Pastor ◽  
James Sadd ◽  
...  
Keyword(s):  
Environmental Health ◽  
Health Inequalities ◽  
Birth Outcomes ◽  
Adverse Birth Outcomes ◽  
Community Vulnerability ◽  
Traffic Exposure ◽  
The Relationship

scholarly journals A Collaborative Research Exploration of Pollutant Mixtures and Adverse Birth Outcomes by Using Innovative Spatial Data Mining Methods: The DoMiNO Project

Challenges ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 25
Author(s):  
Osnat Wine ◽  
Osmar Zaiane ◽  
Alvaro Osornio Vargas
Keyword(s):  
Data Mining ◽  
Environmental Health ◽  
Birth Outcomes ◽  
Environmental Variables ◽  
Collaborative Research ◽  
Research Process ◽  
Spatial Data Mining ◽  
Evaluation Framework ◽  
Adverse Birth Outcomes ◽  
Collaborative Process

Environmental health research is gaining interest due to the global concern of environmental factors impacting health. This research is often multifaceted and becomes complex when trying to understand the participation of multiple environmental variables. It requires the combination of innovative research methods, as well as the collaboration of diverse disciplines in the research process. The application of collaborative approaches is often challenging for interdisciplinary teams, and much can be learned from in-depth observation of such processes. We share here a case report describing initial observations and reflections on the collaborative research process of the Data Mining and Neonatal Outcomes (DoMiNO) project (2013–2018), which aimed to explore associations between mixtures of air pollutants and other environmental variables with adverse birth outcomes by using an innovative data mining approach. The project was built on interdisciplinary and user knowledge participation with embedded evaluation framework of its collaborative process. We describe the collaborative process, the benefits and challenges encountered, and provide insights from our experience. We identified that interdisciplinary research requires time and investment in building relationships, continuous learning, and engagement to build bridges between disciplines towards co-production, discovery, and knowledge translation. Learning from interdisciplinary collaborative research experiences can facilitate future research in the challenging field of environmental health.

scholarly journals Blood pressure trajectories during pregnancy and associations with adverse birth outcomes among HIV-infected and HIV-uninfected women in South Africa: a group-based trajectory modelling approach

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Thokozile R. Malaba ◽  
◽  
Annibale Cois ◽  
Hlengiwe P. Madlala ◽  
Mushi Matjila ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Birth Outcomes ◽  
Low Birthweight ◽  
Care Facility ◽  
Adverse Birth Outcomes ◽  
Multinomial Regression ◽  
Increased Risk ◽  
Trajectory Group ◽  
The Relationship ◽  
Trajectory Modelling

Abstract Background High blood pressure (BP) late in pregnancy is associated with preterm delivery (PTD); BP has also been associated with HIV and antiretroviral therapy (ART), but whether the relationship between BP assessed longitudinally over pregnancy and PTD and low birthweight (LBW) is modified by HIV/ART is unclear. We hypothesise the presence of distinctive BP trajectories and their association with adverse birth outcomes may be mediated by HIV/ART status. Methods We recruited pregnant women at a large primary care facility in Cape Town. BP was measured throughout pregnancy using automated monitors. Group-based trajectory modelling in women with ≥3 BP measurements identified distinct joint systolic and diastolic BP trajectory groups. Multinomial regression assessed BP trajectory group associations with HIV/ART status, and Poisson regression with robust error variance was used to assess risk of PTD and LBW. Results Of the 1583 women in this analysis, 37% were HIV-infected. Seven joint trajectory group combinations were identified, which were categorised as normal (50%), low normal (25%), high normal (20%), and abnormal (5%). A higher proportion of women in the low normal group were HIV-infected than HIV-uninfected (28% vs. 23%), however differences were not statistically significant (RR 1.27, 95% CI 0.98–1.63, reference category: normal). In multivariable analyses, low normal trajectory (aRR0.59, 0.41–0.85) was associated with decreased risk of PTD, while high normal (aRR1.48, 1.12–1.95) and abnormal trajectories (aRR3.18, 2.32–4.37) were associated with increased risk of PTD, and abnormal with increased risk of LBW (RR2.81, 1.90–4.15). Conclusions While HIV/ART did not appear to mediate the BP trajectories and adverse birth outcomes association, they did provide more detailed insights into the relationship between BP, PTD and LBW for HIV-infected and uninfected women.

scholarly journals Cohort profile: Prematurity Immunology in Mothers living with HIV and their infants Study (PIMS)

BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e047133
Author(s):  
Thokozile R Malaba ◽  
Landon Myer ◽  
Clive Gray ◽  
Marie-Louise Newell
Keyword(s):  
Immune Responses ◽  
Birth Outcomes ◽  
Mononuclear Cells ◽  
Clinical Care ◽  
Blood Pressure Measurement ◽  
Hiv Care ◽  
Adverse Birth Outcomes ◽  
Clinical Records ◽  
Living With Hiv ◽  
The Relationship

PurposePrematurity Immunology in Mothers living with HIV and their infants Study (PIMS) is a prospective cohort study in South Africa investigating the association between antiretroviral therapy (ART) use, preterm delivery (PTD) and small-for-gestational age (SGA) live births. PIMS main hypotheses are that ART initiation in pregnancy and ART-induced hypertension are associated with PTD and SGA respectively and that reconstitution of cellular immune responses in women on ART from before pregnancy results in increases in PTD of GA infants.ParticipantsPregnant women (n=3972) aged ≥18 years regardless of HIV status recruited from 2015 to 2016 into the overall PIMS cohort (2517 HIV-negative, 1455 living with HIV). A nested cohort contained 551 women living with HIV who were ≤24 weeks’ GA on ultrasound: 261 initiated ART before pregnancy, 290 initiated during the pregnancy.Findings to dateWomen in the overall cohort were followed antenatally through to delivery using routine clinical records; further women in the nested cohort were actively followed up until 12 months post partum, with data collected on maternal health (HIV care and ART use, clinical care and intercurrent clinical history). Other procedures conducted on the nested cohort included physical examinations (anthropometry, blood pressure measurement), assessment of fetal growth (ultrasound), maternal and infant phlebotomy for storage of plasma, RNA and peripheral blood mononuclear cells, collection of delivery specimens (placenta and cord blood) and infant 12-month developmental assessment. Preliminary findings have contributed to our understanding of risk factors for adverse birth outcomes, and the relationship between pregnancy immunology, HIV/ART and adverse birth outcomes.Future plansUsing specimens collected from study participants living with HIV throughout pregnancy and first year of life, the PIMS provides a valuable platform for answering a variety of research questions focused on temporal changes of immunology markers in women whose immune status is altered by HIV infection, and how ART initiated during the pregnancy affects immune responses. The relationship between these immunological changes with adverse birth outcomes as well as possible longer-term impact of exposure to ART in fetal and early life will be explored. Additionally, further active and passive follow-up of mothers and their infants is planned at school-going age and beyond to chart growth, morbidity and development, as well as changes in family circumstances.

scholarly journals Linking Social Vulnerability and Adverse Birth Outcomes in the Southeast United States

2021 ◽  
Author(s):  
Hoda Fotovvat ◽  
Christopher T. Emrich
Keyword(s):  
United States ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Birth Outcomes ◽  
Social Vulnerability ◽  
National Average ◽  
Adverse Birth Outcomes ◽  
House Values ◽  
Vulnerability Indicators ◽  
The Relationship

Abstract Background This study aims to explore the relationship between social vulnerability (SoVI)indicators (race/ethnicity, population structure, socioeconomic status, housing structure, and access/functional needs) with low birth weight (LBW) and preterm delivery (PTD) rates across the Southeastern United States. Methods Annual low birth weight and premature birth rates for all counties were collected between 2000 and 2015. LBW and PTD were recoded into two categories below (0) and above (1) the annual national average for each year. Multinomial logistic regression (MLR) was employed to conduct regression analysis to investigate the relationship. Results Twenty-six and twenty-four different social vulnerability indicators were influential in predicting low birth weight rates and preterm delivery across the SE United States from 2005–2015, respectively. Racial and ethnic variables were among the most frequent influential social vulnerability indicators of low birth weights. Like race and ethnicity, counties with low and medium house values have a higher likelihood of low LBW compared to counties with higher house values. Unlike LBW, race and ethnic characteristics influence PTD rates across the study area in different ways. Whereas LBW rates are driven up in counties with low/medium Hispanic populations compared to high percentage counties, PTD is more strongly associated with Black communities. Further, population structure and socioeconomic status indicators provide the most robust indication of counties more likely to have higher PTD than the national average. Conclusion Influential variables point toward a dire need to comprehensively understand the links between social vulnerability and LBW and PTD. Moving toward a comprehensive view of social vulnerability borne out of the hazards literature provides a more robust understanding of the drivers of adverse birth outcomes that has rarely been addressed in the literature.

scholarly journals RELATIONSHIP BETWEEN EARLY CHILDHOOD CARIES AND ADVERSE BIRTH OUTCOMES

2021 ◽  
Vol 31 (3) ◽  
pp. 196-200
Author(s):  
Abdulla Varoneckas ◽  
Kotryna Jasinskaitė ◽  
Asta Varašiūtė
Keyword(s):  
Early Childhood ◽  
Birth Outcomes ◽  
Early Childhood Caries ◽  
Scientific Evidence ◽  
Case Control ◽  
Adverse Birth Outcomes ◽  
Healthy Children ◽  
Cross Sectional ◽  
The Relationship ◽  
Childhood Caries

Purpose: The aim of this review was to assess the relationship between adverse birth outcomes and early childhood caries. Methods: Two reviewers searched different databases from February 2020. Results: 1376 articles were shown after the initial electronic databases search. The authors identified 10 studies investigating the incidence of dental caries among children with primary dentition, covering 79284 children, with their age ranging from 0,5 to 6 years. The studies were published from 2010 to 2020 and included retrospective, cohort, case control and cross-sectional studies. Conclusion: The found scientific evidence demonstratedthat children with adverse birth outcomes are more likely to experience caries than healthy children.

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