PAST ARSENIC EXPOSURE, ARSENICAL SKIN LESIONS AND ABNORMALITY OF LUNG FUNCTION IN SOUTHWESTERN TAIWAN

2011 ◽  
Vol 2011 (1) ◽  
Author(s):  
Ling-I Hsu ◽  
Chien-Jen Chen
Keyword(s):  
Lung Function ◽  
Arsenic Exposure ◽  
Skin Lesions ◽  
Southwestern Taiwan ◽  
Arsenical Skin Lesions

Chronic low-level arsenic exposure reduces lung function in male population without skin lesions

2014 ◽  
Vol 59 (4) ◽  
pp. 655-663 ◽  
Author(s):  
Debangshu Das ◽  
Banani Bindhani ◽  
Bidisha Mukherjee ◽  
Hirak Saha ◽  
Priyanka Biswas ◽  
...  
Keyword(s):  
Lung Function ◽  
Arsenic Exposure ◽  
Skin Lesions ◽  
Male Population ◽  
Low Level

scholarly journals ARSENIC POLLUTION AND REMEDIAL MEASURES IN WEST BENGAL: AN OVERVIEW

2020 ◽  
pp. 52-56
Author(s):  
Abhijnan Bhat ◽  
Subhas Chandra Bhat
Keyword(s):  
West Bengal ◽  
Arsenic Exposure ◽  
Extended Period ◽  
Arsenic Species ◽  
Skin Lesions ◽  
Contaminated Water ◽  
Arsenic Toxicity ◽  
Delta Plain ◽  
Alternative Water ◽  
Arsenical Skin Lesions

During the past twenty years, Arsenic (As) contamination via groundwater has become a significant issue worldwide and is now a serious concern within the Indo-Bangladesh Gangetic delta. Arsenic enters physical body through contaminated groundwater consumed as beverage. Food safety in this region is facing severe consequences as bio-accumulation of Arsenic is happening through food crops irrigated with As-contaminated water. Chronic exposure to Arsenic may cause not only cancerous and non-cancer health effects. Reports suggest that about 20% population in West Bengal is very affected. Various techniques are being introduced to supply arsenic-free beverage at a reasonable cost. But a rigorous change in habit and state of mind for procuring safe beverage in those surviving in As-contaminated zones is that the most essential step towards curbing the fatal consequences of arsenic exposure. Harvesting rain water and utilization of proper purification techniques are often considered a possible alternative of safe beverage. Arsenic in groundwater above the WHO maximum permissible limit of 0.01 mg l−1 has been found in six districts of West Bengal covering a neighborhood of 34 000 km2 with a population of 30 million. at the present, 37 administrative blocks by the side of the River Ganga and adjoining areas are affected. Areas suffering from arsenic contamination in groundwater are all located within the upper delta plain, and are mostly within the abandoned meander belt. Quite 8,00,000 people from 312 villages/wards are affected with arsenic contaminated beverage and amongst them a minimum of 175 000 people show arsenical skin lesions. Thousands of tube-well waters in these six districts are analyzed for arsenic species. Hair, nails, scales, urine, liver tissue analyses show elevated concentrations of arsenic in people drinking arsenic-contaminated water for an extended period. The source of the arsenic is geological. Bore-hole sediment analyses show high arsenic concentrations in just few soil layers which is found to be related to iron-pyrites. Various social problems arise thanks to arsenical skin lesions in these districts. Poor socio-economic conditions, malnutrition, illiteracy, food habits and intake of arsenic-contaminated water for several years have aggravated the arsenic toxicity. altogether these districts, major water demands are met from groundwater and therefore the geochemical reaction, caused by high withdrawal of water could also be the explanation for arsenic leaching from the source. If alternative water resources aren't utilised, an honest percentage of the 30 million people of those six districts may suffer from arsenic toxicity within the near future.

scholarly journals Association between Multi-level Inorganic Arsenic Exposure from Drinking Water and Skin Lesions in China

2006 ◽  
Vol 3 (3) ◽  
pp. 262-267 ◽  
Author(s):  
Xiaojuan Guo ◽  
Yoshihisa Fujino ◽  
Xiaolei Ye ◽  
Jun Liu ◽  
Takesumi Yoshimura
Keyword(s):  
Drinking Water ◽  
Arsenic Exposure ◽  
Inorganic Arsenic ◽  
Skin Lesions ◽  
Multi Level

scholarly journals A Prospective Study of Arsenic Exposure From Drinking Water and Incidence of Skin Lesions in Bangladesh

2011 ◽  
Vol 174 (2) ◽  
pp. 185-194 ◽  
Author(s):  
M. Argos ◽  
T. Kalra ◽  
B. L. Pierce ◽  
Y. Chen ◽  
F. Parvez ◽  
...  
Keyword(s):  
Drinking Water ◽  
Prospective Study ◽  
Arsenic Exposure ◽  
Skin Lesions ◽  
A Prospective Study

Model Sensitivity in an Analysis of Arsenic Exposure and Bladder Cancer in Southwestern Taiwan

1999 ◽  
pp. 207-215 ◽  
Author(s):  
Knashawn H. Morales ◽  
Louise M. Ryan ◽  
Kenneth G. Brown ◽  
Tsung-Li Kuo ◽  
Chien-Jen Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Arsenic Exposure ◽  
Model Sensitivity ◽  
Southwestern Taiwan

scholarly journals Chronic Arsenic Exposure through Drinking Water and Risk of Type 2 Diabetes Mellitus: A Study from Bangladesh

2018 ◽  
Vol 37 (1) ◽  
pp. 5-12 ◽  
Author(s):  
Mst Karimon Nesha ◽  
Md Nazrul Islam ◽  
Nira Ferdous ◽  
Fahid Bin Nazrul ◽  
Johannes J Rasker
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Drinking Water ◽  
Fasting Blood Glucose ◽  
Arsenic Exposure ◽  
Skin Lesions ◽  
World Health ◽  
Chronic Arsenic Exposure

The well-documented fact that chronic arsenic exposure can lead to skin lesions, atherosclerotic diseases and cancers. The findings of association between arsenic exposure and diabetes mellitus indicate additional risk to human health. The aim of this study was to observe the association of chronic arsenic exposure from drinking water and risk of development of type 2 diabetes mellitus. To this end, a cross-sectional study was conducted in Comilla district of Bangladesh where ground water is heavily contaminated with arsenic. The individuals unexposed to arsenic were recruited from the Jhenaidah district. People with arsenic-related skin lesions were defined as subjects exposed to arsenic. Diabetes was defined if fasting blood glucose (FBG)>6.1 mmol/L following World Health Organization (WHO) guidelines. The common odds ratio for diabetes mellitus among subjects exposed to arsenic was 3.5 (95% confidence interval 1.1-10.9). After adjustment for age, sex and BMI, the Mantel-Haenszel weighted prevalence ratio was 3.5 (95% CI: 1.1-11.1); 3.7 (95% CI: 1.1-11.8) and 4.4 (95% CI: 1.1-17.2) respectively. The indicated relationships were significant (P<0.05). The observations suggested, chronic arsenic exposure through drinking water may be a risk factor of type 2 diabetes mellitus. J Bangladesh Coll Phys Surg 2019; 37(1): 5-12

scholarly journals Patient-Reported Outcomes of Arsenic-Related Skin Lesions in China

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Yajia Li ◽  
Danrong Jing ◽  
Yi Xiao ◽  
Xiaoyan Huang ◽  
Minxue Shen
Keyword(s):  
Sleep Quality ◽  
Quality Index ◽  
Patient Reported Outcomes ◽  
Rating Scale ◽  
Arsenic Concentration ◽  
Arsenic Exposure ◽  
Skin Lesions ◽  
Anxiety And Depression ◽  
Patient Reported ◽  
Chronic Arsenic Exposure

Purpose. Previous studies confirmed that chronic arsenic exposure could lead to pigmentary changes and hyperkeratosis. However, skin health-related quality of life (HRQoL) among people under lifetime arsenic exposure remains underappreciated. Our study is aimed at investigating several patient-reported outcomes in a population under chronic arsenic exposure. Patients and Methods. A cross-sectional study was conducted in communities in Shimen, China. Dermatologists performed skin examinations for participants. Patient-reported outcomes (PROs) included HRQoL, itch, sleep quality, and symptoms of anxiety and depression. The Dermatology Life Quality Index (DLQI) was used to measure skin HRQoL. The numerical rating scale (NRS) was used to measure the intensity of itching. Sleep disturbance was measured by Pittsburgh Sleep Quality Index (PSQI). Anxiety and depression were measured by two-item Generalized Anxiety Disorder (GAD-2) and Patient Health Questionnaire (PHQ-2), respectively. Results. A total of 464 participants suffering from arsenic-related skin lesions finished the assessment of DLQI. Pigmentary changes and arsenical keratosis were not associated with the patient-reported outcomes except PHQ-2. Hair arsenic exceeding 1 μg/g was associated with higher itch NRS and DLQI (P<0.05). Itch NRS (adjusted β=0.80, 95% CI: 0.70–0.90, P<0.01) and hair arsenic concentration (adjusted β=0.12, 95% CI: 0.01–0.24, P<0.05) were independently associated with the DLQI. Conclusion. HRQoL, sleep quality, and mental wellbeing are impaired in residents under chronic arsenic exposure. Itching and hair arsenic are independent risk factors for impaired HRQoL.

Analysis of T-cell proliferation and cytokine secretion in the individuals exposed to arsenic

2008 ◽  
Vol 27 (5) ◽  
pp. 381-386 ◽  
Author(s):  
R Biswas ◽  
P Ghosh ◽  
N Banerjee ◽  
JK Das ◽  
T Sau ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Opportunistic Infections ◽  
Arsenic Exposure ◽  
Skin Lesions ◽  
Cytokine Secretion ◽  
T Cell Proliferation ◽  
Internal Organs ◽  
Tnf Α ◽  
Dose Dependent

Over six million people in nine districts of West Bengal, India are exposed to very high levels of arsenic primarily through their drinking water. More than 300,000 people showed arsenic-induced skin lesions in these districts. This is regarded as the greatest arsenic calamity in the world. Chronic arsenicosis causes varied dermatological signs ranging from pigmentation changes, hyperkeratosis to non-melanocytic cancer of skin, and also malignancies in different internal organs. Higher incidences of opportunistic infections are found in the arsenic-exposed individuals, indicating that their immune systems may be impaired somehow. We have thus investigated the effect of arsenic on T-cell proliferation and cytokine secretion in 20 individuals with arsenic-induced skin lesions and compared the results with 18 arsenic-unexposed individuals. A marked dose-dependent suppression of Concanavalin A (Con A) induced T-cell proliferation was observed in the arsenic-exposed individuals compared with the unexposed ( P < 0.001) individuals. This correlated with a significant decrease in the levels of secreted cytokines by the T cells (TNF-α, IFN-γ, IL2, IL10, IL5, and IL4) in the exposed individuals ( P < 0.001). Thus it can be inferred that arsenic exposure can cause immunosuppression in humans.

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