scholarly journals Prospective Associations of Early Pregnancy Metal Mixtures with Mitochondria DNA Copy Number and Telomere Length in Maternal and Cord Blood

2021 ◽  
Vol 129 (11) ◽  
Author(s):  
Anna R. Smith ◽  
Pi-I D. Lin ◽  
Sheryl L. Rifas-Shiman ◽  
Mohammad L. Rahman ◽  
Diane R. Gold ◽  
...  
Keyword(s):  
Cord Blood ◽  
Telomere Length ◽  
Early Pregnancy ◽  
Copy Number ◽  
Dna Copy Number ◽  
Metal Mixtures ◽  
Mitochondria Dna

scholarly journals Relative telomere length and mitochondria DNA copy number in ligamentum flavum of lumbar stenosis patients

2016 ◽  
Vol 7 ◽  
pp. 132
Author(s):  
Sinsuda Dechsupa ◽  
Worawat Limthongkul ◽  
Wicharn Yingsakmongkol ◽  
Weerasak Singhatanadgige ◽  
Sittisak Honsawek
Keyword(s):  
Telomere Length ◽  
Copy Number ◽  
Ligamentum Flavum ◽  
Lumbar Stenosis ◽  
Dna Copy Number ◽  
Relative Telomere Length ◽  
Mitochondria Dna

Loss of the Association between Telomere Length and Mitochondrial DNA Copy Number Contribute to Colorectal Carcinogenesis

2017 ◽  
Vol 24 (2) ◽  
pp. 323-328 ◽  
Author(s):  
Hyunsu Lee ◽  
Ji-Hyoung Cho ◽  
Won-Jin Park ◽  
Soo-Jung Jung ◽  
In-Jang Choi ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Telomere Length ◽  
Copy Number ◽  
Colorectal Carcinogenesis ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

scholarly journals Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer

2017 ◽  
Vol 14 (1) ◽  
pp. 925-929 ◽  
Author(s):  
Soo-Jung Jung ◽  
Ji-Hyoung Cho ◽  
Won-Jin Park ◽  
Yu-Ran Heo ◽  
Jae-Ho Lee
Keyword(s):  
Gastric Cancer ◽  
Mitochondrial Dna ◽  
Telomere Length ◽  
Copy Number ◽  
Diffuse Gastric Cancer ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

Associations of mitochondrial DNA copy number and deletion rate with early pregnancy loss

Mitochondrion ◽  
2020 ◽  
Vol 55 ◽  
pp. 48-53
Author(s):  
Mujin Ye ◽  
Weihui Shi ◽  
Yanhui Hao ◽  
Lanlan Zhang ◽  
Songchang Chen ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Early Pregnancy ◽  
Copy Number ◽  
Pregnancy Loss ◽  
Early Pregnancy Loss ◽  
Dna Copy Number ◽  
Deletion Rate ◽  
Mitochondrial Dna Copy Number

scholarly journals Combined Effect of Telomere Length and Mitochondrial DNA Copy Number As a Potential Biomarker Indicating PE Risk: a Case-Control Study in a Chinese Population

2022 ◽  
Author(s):  
Ruyi Zhang ◽  
Jiangbo Du ◽  
Zhendong Xiao ◽  
Yuan Jiang ◽  
Qiao Weng ◽  
...  
Keyword(s):  
Cord Blood ◽  
Telomere Length ◽  
Copy Number ◽  
Case Control Study ◽  
Quantitative Polymerase Chain Reaction ◽  
Maternal Blood ◽  
Case Control ◽  
Combined Effect ◽  
Potential Biomarker ◽  
Control Study

Abstract Purpose To explore changes of Telomere length (TL) and mitochondrial copy number (mtDNA-CN) in preeclampsia (PE) and to evaluatethe combined effect of maternal TL and mtDNA-CN on PE risk.Methods A case-control study of 471 subjects (130 PE cases and 341 age frequency matched controls) was conducted in Nanjing Drum Tower Hospital, Jiangsu Province of China. Relative telomere length (RTL) and mtDNA-CN were measured using quantitative polymerase chain reaction (qPCR) and PE risk was calculated between groups by logistic regression analyses.Results PE patients displayed longer RTL (0.48 versus 0.30) and higher mtDNA-CN (3.02 versus 2.00) in maternal bloodas well as longer cord blood RTL(0.61 versus 0.35) but lower mtDNA-CN (1.69 versus 5.49) in cord blood (all p<0.001). Exercise during pregnancy exerted an obvious effect of prolonging maternal telomere length. Multiparous, women with folic acid intake during early pregnancy and those delivered vaginally showed longer telomere length while those factors imposed no or opposite effect on RTL in PE cases. Furthermore, RTL and mtDNA-CN were positively correlated in controls (in maternal blood r=0.18, p<0.01; in cord blood r=0.19, p<0.001), but this correlation was disrupted in PE cases, no matter in maternal blood or in cord blood. Longer maternal RTL and higher mtDNA-CN were associated with higher risk of PE, and the ROC curve of RTL and mtDNA-CN in predicting PE risk presented an AUC of 0.755(95%CI: 0.698-0.812).Conclusions Interaction of TL and mtDNA-CN may play an important role in pathogenesis of PE and it could be a potential biomarker indicating PE risk.

The association between mitochondrial DNA copy number, telomere length, and tubal pregnancy

Placenta ◽  
2020 ◽  
Vol 97 ◽  
pp. 108-114
Author(s):  
Zhen Huang ◽  
Xiaoya Zhao ◽  
Huiyu Zhang ◽  
Guiling Liang ◽  
Hang Qi ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Telomere Length ◽  
Copy Number ◽  
Tubal Pregnancy ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

scholarly journals Positive association and future perspectives of mitochondrial DNA copy number and telomere length – a pilot twin study

2019 ◽  
Author(s):  
Dóra Melicher ◽  
Anett Illés ◽  
Levente Littvay ◽  
Ádám Domonkos Tárnoki ◽  
Dávid László Tárnoki ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Telomere Length ◽  
Twin Study ◽  
Copy Number ◽  
Positive Association ◽  
Future Perspectives ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number
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