scholarly journals Transcriptome-Wide Prediction and Measurement of Combined Effects Induced by Chemical Mixture Exposure in Zebrafish Embryos

2021 ◽  
Vol 129 (4) ◽  
Author(s):  
A. Schüttler ◽  
G. Jakobs ◽  
J.M. Fix ◽  
M. Krauss ◽  
J. Krüger ◽  
...  
Keyword(s):  
Zebrafish Embryos ◽  
Combined Effects ◽  
Chemical Mixture

scholarly journals Increased apoptosis, reduced Wnt/β-catenin signaling, and altered tail development in zebrafish embryos exposed to a human-relevant chemical mixture

Chemosphere ◽  
2021 ◽  
Vol 264 ◽  
pp. 128467
Author(s):  
Anna Smirnova ◽  
Anna Mentor ◽  
Petter Ranefall ◽  
Carl-Gustaf Bornehag ◽  
Björn Brunström ◽  
...  
Keyword(s):  
Zebrafish Embryos ◽  
Chemical Mixture ◽  
Tail Development

scholarly journals Combined effects of depleted uranium and ionising radiation on zebrafish embryos

2015 ◽  
Vol 167 (1-3) ◽  
pp. 311-315 ◽  
Author(s):  
C. Y. P. Ng ◽  
S. Pereira ◽  
S. H. Cheng ◽  
C. Adam-Guillermin ◽  
J. Garnier-Laplace ◽  
...  
Keyword(s):  
Depleted Uranium ◽  
Ionising Radiation ◽  
Zebrafish Embryos ◽  
Combined Effects

scholarly journals Combined effects of alpha particles and depleted uranium on Zebrafish ( Danio rerio ) embryos

2016 ◽  
Vol 57 (4) ◽  
pp. 343-355 ◽  
Author(s):  
Candy Y.P. Ng ◽  
Sandrine Pereira ◽  
Shuk Han Cheng ◽  
Christelle Adam-Guillermin ◽  
Jacqueline Garnier-Laplace ◽  
...  
Keyword(s):  
Alpha Particle ◽  
Danio Rerio ◽  
Depleted Uranium ◽  
Alpha Particles ◽  
High Dose ◽  
Zebrafish Embryos ◽  
Combined Effects ◽  
Spontaneous Transformation ◽  
Particle Dose ◽  
Danio Rerio Embryos

Abstract The combined effects of low-dose or high-dose alpha particles and depleted uranium (DU) in Zebrafish ( Danio rerio ) embryos were studied. Three schemes were examined—(i) [I L U L ]: 0.44 mGy alpha-particle dose + 10 µg/l DU exposure, (ii) [I H U H ]: 4.4 mGy alpha-particle dose + 100 µg/l DU exposure and (iii) [I H U L ]: 4.4 mGy alpha-particle dose + 10 µg/l DU exposure—in which Zebrafish embryos were irradiated with alpha particles at 5 h post fertilization (hpf) and/or exposed to uranium at 5–6 hpf. The results were also compared with our previous work, which studied the effects of [I L U H ]: 0.44 mGy alpha-particle dose + 100 µg/l DU exposure. When the Zebrafish embryos developed to 24 hpf, the apoptotic signals in the entire embryos, used as the biological endpoint for this study, were quantified. Our results showed that [I L U L ] and [I H U L ] led to antagonistic effects, whereas [I H U H ] led to an additive effect. The effect found for the previously studied case of [I L U H ] was difficult to define because it was synergistic with reference to the 100 µg/l DU exposure, but it was antagonistic with reference to the 0.44 mGy alpha-particle dose. All the findings regarding the four different schemes showed that the combined effects critically depended on the dose response to each individual stressor. We also qualitatively explained these findings in terms of promotion of early death of cells predisposed to spontaneous transformation by alpha particles, interacting with the delay in cell death resulting from various concentrations of DU exposure.

scholarly journals Transgenic (cyp19a1b-GFP) zebrafish embryos as a tool for assessing combined effects of oestrogenic chemicals

2013 ◽  
Vol 138-139 ◽  
pp. 88-97 ◽  
Author(s):  
Karina Petersen ◽  
Eva Fetter ◽  
Olivier Kah ◽  
François Brion ◽  
Stefan Scholz ◽  
...  
Keyword(s):  
Zebrafish Embryos ◽  
Combined Effects

Toxicities of microplastic fibers and granules on the development of zebrafish embryos and their combined effects with cadmium

Chemosphere ◽  
2020 ◽  
pp. 128677
Author(s):  
Haodong Cheng ◽  
Yifan Feng ◽  
Zhenghua Duan ◽  
Xinyue Duan ◽  
Shuang Zhao ◽  
...  
Keyword(s):  
Zebrafish Embryos ◽  
Combined Effects

Effects of Retinoic Acid and 1,25-Dihydroxyvitamin D3 on IFN-gamma Secretion by Mononuclear Leukocytes from Nulliparous and Postparturient Dairy Cattle

2000 ◽  
Vol 70 (3) ◽  
pp. 92-101 ◽  
Author(s):  
Burim Ametaj ◽  
Brian Nonnecke ◽  
Ronald Horst ◽  
Donald Beitz
Keyword(s):  
Retinoic Acid ◽  
Dairy Cattle ◽  
Dairy Cows ◽  
Dairy Cow ◽  
Pokeweed Mitogen ◽  
Mononuclear Leukocytes ◽  
Combined Effects ◽  
Ifn Gamma ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D

Individual and combined effects of several isomers of retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on interferon-gamma (IFN-gamma) secretion by blood mononuclear leukocytes (MNL) from nulliparous and postparturient Holstein cattle were evaluated in vitro. In the first experiment, effects on incubation period (24 to 72 hours) and time of supplementation (0 to 32 hours) with all-trans, 9-cis, 13-cis-, and 9,13-dicis-RAs (0 to 100 nM) on IFN-gamma secretion by pokeweed mitogen (PWM)-stimulated (0 and 10 mug/ml) MNL from nulliparous cattle were evaluated. In the second experiment, MNL from postparturient cows (bled at 0, 2, 4, and 16 days postpartum) were stimulated with PWM (0 and 10 mug/ml) in the presence of RA isomers (9-cis- or 9,13-dicis-RA; 0 to 100 nM), 1,25-(OH)2D3 (0 to 100 nM), or with combinations of these metabolites. The results show that individual isomers of RA had no effect on IFN-gamma secretion by PWM-stimulated MNL from nulliparous or postparturient cows. Furthermore 1,25-dihydroxyvitamin D3 inhibited IFN-gamma secretion by MNL from nulliparous and postparturient dairy cows; however, the degree of inhibition was greater when 9-cis- and 9,13-dicis-RA were also present in the cultures. Finally mononuclear leukocytes from postparturient dairy cows produced substantially less IFN-gamma than did MNL from nulliparous cattle. It is concluded that retinoic acids individually did not affect the capacity of leukocytes from dairy cattle to secrete IFN-gamma. This result is in marked contrast to studies in monogastric species indicating that RAs inhibit IFN-gamma secretion by peripheral blood T cells. Inhibition of IFN-gamma secretion by 1,25-(OH)2D3 was potentiated by 9-cis- and 9,13-di-cis-retinoics acids, suggesting that an excess of dietary vitamins A and D may compromise further the naturally immunosuppressed postparturient dairy cow. Additional research is necessary to determine if the combined effects of these metabolites on IFN-gamma secretion represent an increased susceptibility of the dairy cow to infectious diseases during the periparturient period. Lower secretion of IFN-gamma by MNL from postpartutient dairy cows, relative to nulliparous cattle, suggests that recently-calved cows are naturally immunosuppressed.

Combined effects of form- and meaning-based predictability on perceived clarity of speech.

2018 ◽  
Vol 44 (2) ◽  
pp. 277-285 ◽  
Author(s):  
Carine Signoret ◽  
Ingrid Johnsrude ◽  
Elisabet Classon ◽  
Mary Rudner
Keyword(s):  
Combined Effects

Mapping of accumulation of SeNPs in developing zebrafish embryos and larvae: a new method using SEM with energy dispersive X‐ray spectrometer

2017 ◽  
Vol 12 (7) ◽  
pp. 497-499
Author(s):  
Kalimuthu Kalishwaralal ◽  
Subhaschandrabose Jeyabharathi ◽  
Krishnan Sundar ◽  
Azhaguchamy Muthukumaran
Keyword(s):  
Energy Dispersive ◽  
New Method ◽  
Zebrafish Embryos ◽  
X Ray
Sign in / Sign up

Export Citation Format

Share Document