scholarly journals Prenatal Exposure to Glyphosate and Its Environmental Degradate, Aminomethylphosphonic Acid (AMPA), and Preterm Birth: A Nested Case–Control Study in the PROTECT Cohort (Puerto Rico)

2021 ◽  
Vol 129 (5) ◽  
pp. 057011 ◽  
Author(s):  
Monica K. Silver ◽  
Jennifer Fernandez ◽  
Jason Tang ◽  
Anna McDade ◽  
Jason Sabino ◽  
...  
Keyword(s):  
Puerto Rico ◽  
Preterm Birth ◽  
Prenatal Exposure ◽  
Case Control Study ◽  
Case Control ◽  
Aminomethylphosphonic Acid ◽  
Nested Case Control ◽  
Control Study

scholarly journals Factor V Leiden as a risk factor for preterm birth - a population-based nested case-control study

2011 ◽  
Vol 9 (1) ◽  
pp. 71-78 ◽  
Author(s):  
L. M. HILTUNEN ◽  
H. LAIVUORI ◽  
A. RAUTANEN ◽  
R. KAAJA ◽  
J. KERE ◽  
...  
Keyword(s):  
Risk Factor ◽  
Preterm Birth ◽  
Case Control Study ◽  
Factor V Leiden ◽  
Population Based ◽  
Case Control ◽  
Factor V ◽  
Nested Case Control ◽  
Control Study

scholarly journals Associations Between Gestational Environmental Phenols and Preterm Birth; a Nested Case-Control Study

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Michael S. Bloom ◽  
Kelly Garcia ◽  
Roy R. Gerona ◽  
Edward L. Valachovic ◽  
Victor Y. Fujimoto ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Gut microbial-related metabolite trimethylamine-N-oxide and its precursor L-carnitine are associated with spontaneous preterm birth: a nested case-control study

2019 ◽  
Author(s):  
Xing Chen ◽  
Ning Huang ◽  
Chaoqun Liu ◽  
Yue Chen ◽  
Lulu Huang ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Preterm Labor ◽  
Case Control Study ◽  
Case Control ◽  
Normal Weight ◽  
Maternal Serum ◽  
Spontaneous Preterm Birth ◽  
Nested Case Control ◽  
Related Metabolite ◽  
Control Study

Abstract Background: Gut microbiota has been proven to disease susceptibility and may lead to increased risk of preterm birth. To date, the link of gut microbial-related metabolite trimethylamine-N-oxide (TMAO), L-carnitine, and betaine, with spontaneous preterm birth (sPTB) has not been established. This study aimed to investigate the association of TMAO, L-carnitine and betaine, with sPTB risk. Methods: A nested case-control study was designed including 129 sPTB cases and 258 controls based on Guangxi Birth Cohort Study. TMAO, L-carnitine, and betaine level in maternal serum were determined by liquid chromatography with mass spectrometry. Conditional logistic regression analyses were used to examine the association between maternal serum metabolites and sPTB. Stratified analyses were further conducted according to BMI and preterm prelabor rupture of membranes. Spline analyses were performed to explore the dose-response relationship between the metabolites and sPTB.Results: Statistically significant association with decreased sPTB risk was observed for the highest L-carnitine (OR: 0.47; 95% CI: 0.23, 0.95). In risk analyses stratified by BMI, similar results were observed in normal weight gravida (BMI: 18.5~23.9 kg/cm2). The significant subtype-specific association with TMAO (OR: 0.43; 95% CI: 0.20, 0.93) and L-carnitine (OR: 0.45; 95% CI: 0.21, 0.97) were observed for preterm labor but not PPROM. Spline regression analysis indicated non-linear associations with TMAO and sPTB risk (P for nonlinearity: 0.057). Significant associations of TMAO with sPTB were observed in normal weight gravida (P = 0.028) and preterm labor subtype (P = 0.025). No statistically significant associations with sPTB risk were observed for betaine (P > 0.05).Conclusions: TMAO and L-carnitine levels in maternal serum are inversely linked with sPTB risk. Discovery of the association between gut-microbiota initiated TMAO metabolism and sPTB may open new avenues for diagnose and therapy.

scholarly journals A Statewide Nested Case–Control Study of Preterm Birth and Air Pollution by Source and Composition: California, 2001–2008

2016 ◽  
Vol 124 (9) ◽  
pp. 1479-1486 ◽  
Author(s):  
Olivier Laurent ◽  
Jianlin Hu ◽  
Lianfa Li ◽  
Michael J. Kleeman ◽  
Scott M. Bartell ◽  
...  
Keyword(s):  
Air Pollution ◽  
Preterm Birth ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study
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