scholarly journals A Quantitative Meta-Analysis of the Relation between Occupational Benzene Exposure and Biomarkers of Cytogenetic Damage

2020 ◽  
Vol 128 (8) ◽  
pp. 087004
Author(s):  
Bernice Scholten ◽  
Jelle Vlaanderen ◽  
Rob Stierum ◽  
Lützen Portengen ◽  
Nat Rothman ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Cytogenetic Damage ◽  
Benzene Exposure

scholarly journals Meta-analysis of Multiple Myeloma and Benzene Exposure.

2001 ◽  
Vol 11 (6) ◽  
pp. 249-254 ◽  
Author(s):  
Tomoko Sonoda ◽  
Yoshie Nagata ◽  
Mitsuru Mori ◽  
Tadao Ishida ◽  
Kohzoh Imai
Keyword(s):  
Multiple Myeloma ◽  
Meta Analysis ◽  
Benzene Exposure

scholarly journals Occupational benzene exposure and the risk of genetic damage: a systematic review and meta-analysis

2019 ◽  
Author(s):  
Yanhua Zhou ◽  
Kun Wang ◽  
Boshen Wang ◽  
Yuepu Pu ◽  
Juan Zhang
Keyword(s):  
Meta Analysis ◽  
Damage Index ◽  
Tail Length ◽  
Control Group ◽  
Tail Moment ◽  
Genetic Damage ◽  
China National Knowledge Infrastructure ◽  
Low Concentration ◽  
Benzene Exposure ◽  
Study Results

Abstract Background To systematically evaluate the influence of benzene exposure on the genetic damage index of workers, and to explore the influence of low concentration benzene exposure on workers’ genetic damage index using 3.25mg/m3 as the boundary value, in order to provide a basis for improved prevention and control of the harm from benzene exposure to the occupational population. Methods We conducted a search of five databases, including Pub Med, Web of Science,China National Knowledge Infrastructure(CNKI), Wan Fang Data and Chongqing VIP, to identify relevant articles up to December 25, 2018. Two researchers independently extracted and carefully evaluated the data according to the inclusion and exclusion criteria of the literature. The imported articles were managed by Endnote X7, and the data were extracted and sorted by Excel 2013. We utilized Stata 12.0 software to perform the meta-analysis in the present study. Results A total of 68 eligible articles were finally included for the synthetic analyses. The meta-analysis results showed that occupational benzene exposure led to significantly increased Micronucleus (MN) frequency, Sister chromatid exchange (SCE) frequency, Chromosome aberration (CA) frequency, Olive Tail moment (OTM), Tail moment (TM), Tail length (TL), and Tail DNA% (T DNA%) compared to the control group (P < 0.05), and the pooled effect value estimates were 1.36, 0.98, 0.76, 1.06, 0.96, 1.78, and 1.42, respectively. Subsequent analysis of the effect of low concentration benzene exposure on genetic damage found significantly increased MN frequency increased compared with the control group (P < 0.05). Conclusions Occupational benzene exposure can affect multiple genetic damage indicators. Even at an exposure concentration lower than 3.25mg/m3, benzene exposure has genotoxicity. These data provide an important scientific basis for the further revision of occupational disease prevention strategies in China. At the same time, increased attention should be focused on the health monitoring of the occupational population exposed to benzene, and health management should be strengthened to improve the health of the occupational population.

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