Evaluation of Developmental Toxicity, Developmental Neurotoxicity, and Tissue Dose in Zebrafish Exposed to GenX and Other PFAS

Shaza Gaballah; Adam Swank; Jon R. Sobus; Xia Meng Howey; Judith Schmid; Tara Catron; James McCord; Erin Hines; Mark Strynar; Tamara Tal

doi:10.1289/ehp5843

Evaluation of Developmental Toxicity, Developmental Neurotoxicity, and Tissue Dose in Zebrafish Exposed to GenX and Other PFAS

Environmental Health Perspectives ◽

10.1289/ehp5843 ◽

2020 ◽

Vol 128 (4) ◽

pp. 047005 ◽

Cited By ~ 12

Author(s):

Shaza Gaballah ◽

Adam Swank ◽

Jon R. Sobus ◽

Xia Meng Howey ◽

Judith Schmid ◽

...

Keyword(s):

Developmental Toxicity ◽

Developmental Neurotoxicity ◽

Tissue Dose

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Evaluation of developmental neurotoxicity: some important issues focused on neurobehavioral development

Interdisciplinary Toxicology ◽

10.2478/v10102-010-0042-y ◽

2008 ◽

Vol 1 (3-4) ◽

pp. 206-210 ◽

Cited By ~ 16

Author(s):

Michal Dubovický ◽

Pavel Kovačovský ◽

Eduard Ujházy ◽

Jana Navarová ◽

Ingrid Brucknerová ◽

...

Keyword(s):

Developmental Toxicity ◽

Mental Deficiency ◽

Developmental Neurotoxicity ◽

Physical Factors ◽

Industrial Chemicals ◽

Behavioral Testing ◽

Behavioral Alterations ◽

Neurobehavioral Development ◽

Complex Approach ◽

Testing Potential

Evaluation of developmental neurotoxicity: some important issues focused on neurobehavioral developmentExposure of the developing organism to industrial chemicals and physical factors represents a serious risk factor for the development of neurobehavioral disorders, such as attention-deficit hyperactivity disorder, autism and mental retardation. Appropriate animal models are needed to test potentially harmful effects and mechanisms of developmental neurotoxicity of various chemical substances. However, there are significant human vs. rat differences in the brain developmental profile which should be taken into account in neurotoxicity studies. Subtle behavioral alterations are hard to detect by traditional developmental toxicity and teratogenicity studies, and in many cases they remain hidden. They can however be revealed by using special behavioral, endocrine and/or pharmacological challenges, such as repeated behavioral testing, exposure to single stressful stimulus or drugs. Further, current neurobehavioral test protocols recommend to test animals up to their adulthood. However some behavioral alterations, such as anxiety-like behavior or mental deficiency, may become manifest in later periods of development. Our experimental and scientific experiences are highly suggestive for a complex approach in testing potential developmental neurotoxicity. Strong emphasis should be given on repeated behavioral testing of animals up to senescence and on using proper pharmacological and/or stressful challenges.

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