scholarly journals Glucose Homeostasis following Diesel Exhaust Particulate Matter Exposure in a Lung Epithelial Cell-Specific IKK2-Deficient Mouse Model

2019 ◽  
Vol 127 (5) ◽  
pp. 057009 ◽  
Author(s):  
Sufang Chen ◽  
Minjie Chen ◽  
Wei Wei ◽  
Lianglin Qiu ◽  
Li Zhang ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Epithelial Cell ◽  
Mouse Model ◽  
Glucose Homeostasis ◽  
Diesel Exhaust ◽  
Deficient Mouse ◽  
Diesel Exhaust Particulate ◽  
Lung Epithelial ◽  
Particulate Matter Exposure ◽  
Exhaust Particulate

scholarly journals Lactic Acid Bacteria Ameliorate Diesel Exhaust Particulate Matter-Exacerbated Allergic Inflammation in a Murine Model of Asthma

Life ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 260
Author(s):  
Sun Woo Jin ◽  
Gi Ho Lee ◽  
Min Jung Jang ◽  
Gyeong Eun Hong ◽  
Jae Young Kim ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Particulate Matter ◽  
Lactic Acid Bacteria ◽  
Diesel Exhaust ◽  
Immunoglobulin E ◽  
Therapeutic Potential ◽  
Airway Remodeling ◽  
Cell Hyperplasia ◽  
Diesel Exhaust Particulate ◽  
Exhaust Particulate

Several air pollution components such as sulfur dioxide, ozone, nitrogen dioxide, and diesel exhaust particulate matter (DEPM) have been linked to the development of asthma. In this study, we investigated the therapeutic potential of three lactic acid bacteria species, Lactobacillus plantarum GREEN CROSS Wellbeing (GCWB)1001, Pediococcus acidilactici GCWB1085, and Lactobacillus rhamnosus GCWB1156, in preventing DEPM-exacerbated asthma in mice. BALB/c mice were first sensitized with ovalbumin (OVA) and were either challenged with OVA or DEPM (DEPM-exacerbated asthma model) by intranasal instillation. All three strains showed no hemolytic activity, suggesting a good safety profile. Oral administration of lactic acid bacteria reduced OVA + DEPM-induced inflammatory infiltration, goblet cell hyperplasia, airway remodeling, and the levels of proinflammatory cytokines and chemokines in bronchoalveolar lavage fluid (BALF). The probiotics also attenuated OVA + DEPM-induced immunoglobulin E (IgE) levels in serum and in BALF, and significantly reduced caspase-3 activity, total collagen level, and matrix metalloproteinase (MMP)-9 activity. In conclusion, lactic acid bacteria such as L. plantarum GCWB1001, P. acidilactici GCWB1085, and L. rhamnosus treatment in mice with asthma showed significant efficacy in preventing lung inflammation exacerbated by DEPM administration.

scholarly journals Geniposide, a Principal Component of Gardeniae Fructus, Protects Skin from Diesel Exhaust Particulate Matter-Induced Oxidative Damage

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Ly Thi Huong Nguyen ◽  
Sang Hyun Ahn ◽  
Uy Thai Nguyen ◽  
In Jun Yang ◽  
Heung Mook Shin
Keyword(s):  
Particulate Matter ◽  
Diesel Exhaust ◽  
Principal Component ◽  
Skin Lesions ◽  
Hacat Cells ◽  
Ros Production ◽  
Protective Effects ◽  
Skin Damage ◽  
Diesel Exhaust Particulate ◽  
Exhaust Particulate

Gardeniae Fructus (GF) is the fruit of Gardenia jasminoides Ellis and is traditionally prescribed to treat pyogenic infections and skin ulcers. This study investigated the protective effects of GF and the underlying mechanism responsible for these effects on diesel exhaust particulate matter- (DEP-) induced skin damage. The protective effects of an ethanolic extract of GF (GFE) and its constituents (geniposidic acid, gardenoside, geniposide, chlorogenic acid, and genipin) were examined by analyzing reactive oxygen species (ROS) production, apoptosis, and tight junction (TJ) protein expression in HaCaT cells. Treatment with GFE dose-dependently inhibited intracellular ROS production and apoptosis by regulating the protein expressions of Bax, Bcl-2, and cytochrome C in DEP-stimulated (100 μg/ml) HaCaT cells. Mechanistic studies revealed that the protective effects of GFE were related to its activation of Nrf2 and HO-1 signaling in HaCaT cells. Geniposide, a main constituent of GFE, enhanced the expression of occludin in DEP-stimulated HaCaT cells. Furthermore, topical application of geniposide reduced the expressions of 8-OHdG and Bax and increased the expression of occludin in the dorsal skin lesions of DEP-stimulated mice. Gardeniae Fructus and its main component geniposide are potential candidates for the repair of DEP-induced skin damage due to their antioxidant and antiapoptotic activities.

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