scholarly journals Erratum: “Hydroxylated Polybrominated Biphenyl Ethers Exert Estrogenic Effects via Nongenomic G Protein–Coupled Estrogen Receptor Mediated Pathways”

2018 ◽  
Vol 126 (6) ◽  
pp. 069001 ◽  
Author(s):  
Lin-Ying Cao ◽  
Xiao-Min Ren ◽  
Yu Yang ◽  
Bin Wan ◽  
Liang-Hong Guo ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Estrogenic Effects ◽  
Polybrominated Biphenyl ◽  
G Protein Coupled

scholarly journals Hydroxylated Polybrominated Biphenyl Ethers Exert Estrogenic Effects via Non-Genomic G Protein–Coupled Estrogen Receptor Mediated Pathways

2018 ◽  
Vol 126 (5) ◽  
pp. 057005 ◽  
Author(s):  
Lin-Ying Cao ◽  
Xiao-Min Ren ◽  
Yu Yang ◽  
Bin Wan ◽  
Liang-Hong Guo ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Estrogenic Effects ◽  
Polybrominated Biphenyl ◽  
G Protein Coupled

Tricresyl phosphate isomers exert estrogenic effects via G protein-coupled estrogen receptor-mediated pathways

2020 ◽  
Vol 264 ◽  
pp. 114747
Author(s):  
Xiaoya Ji ◽  
Na Li ◽  
Mei Ma ◽  
Kaifeng Rao ◽  
Rong Yang ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Tricresyl Phosphate ◽  
Estrogenic Effects ◽  
G Protein Coupled

Known and emerging factors modulating estrogenic effects of endocrine-disrupting chemicals

2014 ◽  
Vol 22 (1) ◽  
pp. 87-98 ◽  
Author(s):  
Wanglong Zhang ◽  
Yu Luo ◽  
Li Zhang ◽  
Qian Cai ◽  
Xuejun Pan
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Posttranslational Modification ◽  
Splice Variants ◽  
Physiological Responses ◽  
Endocrine Disrupting Chemicals ◽  
Estrogenic Effects ◽  
Endocrine Disrupting ◽  
G Protein Coupled ◽  
Estrogen Receptor 1

A variety of endocrine-disrupting chemicals (EDCs) have estrogenic effects and are termed xenoestrogens (XEs). The genomic pathway mediated by estrogen receptors (ERs) has been considered the major explanation for the estrogenic effects elicited by XEs. Presently, nongenomic pathways have achieved considerably more attention because the genomic pathways cannot fully elucidate many biological and physiological responses. Genomic and nongenomic pathways act either separately or cooperatively. XEs activate a variety of signaling pathways and downstream kinases, which in turn alter the posttranslational modification and activation of ERs. Classical ERs and their splice variants reside at the membrane and mediate rapid effects cooperatively with G protein-coupled estrogen receptor 1 (GPER), G protein, and many other signaling molecules. GPER seems more effective in mediating the synthetic chemical-induced effects. There are also feedback and feedforward mechanisms between both pathways. Numerous factors may affect both pathways. Recently, some new layers of regulation on the estrogenic effects were identified. In this review, we summarize these multiple regulation layers and discuss the newly identified factors.

scholarly journals Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway

2017 ◽  
Vol 51 (19) ◽  
pp. 11423-11430 ◽  
Author(s):  
Lin-Ying Cao ◽  
Xiao-Min Ren ◽  
Chuan-Hai Li ◽  
Jing Zhang ◽  
Wei-Ping Qin ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Bisphenol A ◽  
G Protein ◽  
Estrogenic Effects ◽  
Estrogen Receptor Pathway ◽  
G Protein Coupled ◽  
Bisphenol Af

scholarly journals G Protein-Coupled Estrogen Receptor 1 (GPER) as a Novel Target for Schizophrenia Drug Treatment

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Danielle S Macêdo ◽  
Lia Lira Olivier Sanders ◽  
Raimunda das Candeias ◽  
Cyntia de Freitas Montenegro ◽  
David Freitas de Lucena ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptors ◽  
G Protein ◽  
Brain Inflammation ◽  
Antipsychotic Treatment ◽  
New Class ◽  
Estrogen Receptor Modulators ◽  
Novel Target ◽  
G Protein Coupled ◽  
Estrogen Receptor 1

Abstract The observation that a person’s sex influences the onset age of schizophrenia, the course of the disease, and antipsychotic treatment response suggests a possible role for estrogen receptors in the pathophysiology of schizophrenia. Indeed, treatment with adjunctive estrogen or selective estrogen receptor modulators (SERMs) are known to reduce schizophrenia symptoms. While estrogen receptors (ER)α and ERβ have been studied, a third and more recently discovered estrogen receptor, the G protein-coupled estrogen receptor 1 (GPER), has been largely neglected. GPER is a membrane receptor that regulates non-genomic estrogen functions, such as the modulation of emotion and inflammatory response. This review discusses the possible role of GPER in brain impairments seen in schizophrenia and in its potential as a therapeutic target. We conducted a comprehensive literature search in the PubMed/MEDLINE database, using the following search terms: “Schizophrenia,” “Psychosis,” “GPER1 protein,” “Estrogen receptors,” “SERMS,” “GPER1 agonism, “Behavioral symptoms,” “Brain Inflammation.” Studies involving GPER in schizophrenia, whether preclinical or human studies, have been scarce, but the results are encouraging. Agonism of the GPER receptor could prove to be an essential mechanism of action for a new class of “anti-schizophrenia” drugs.

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