scholarly journals Long-Term Fine Particulate Matter Exposure and Major Depressive Disorder in a Community-Based Urban Cohort

2016 ◽  
Vol 124 (10) ◽  
pp. 1547-1553 ◽  
Author(s):  
Kyoung-Nam Kim ◽  
Youn-Hee Lim ◽  
Hyun Joo Bae ◽  
Myounghee Kim ◽  
Kweon Jung ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Particulate Matter ◽  
Depressive Disorder ◽  
Fine Particulate Matter ◽  
Community Based ◽  
Major Depressive ◽  
Fine Particulate ◽  
Particulate Matter Exposure

Association of Short-term Particulate Matter Exposure with Suicide Death Among Major Depressive Disorder Patients: A Time-Stratified Case-Crossover Analysis

2021 ◽  
Author(s):  
In Young Hwang ◽  
Daein Choi ◽  
Jihoon Andrew Kim ◽  
Seulggie Choi ◽  
Jooyoung Chang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Particulate Matter ◽  
Depressive Disorder ◽  
Short Term ◽  
Major Depressive ◽  
Suicide Death ◽  
Case Crossover ◽  
Crossover Analysis ◽  
High Level ◽  
Particulate Matter Exposure

Abstract Objective: There is growing evidence that suggests a potential association between particulate matter (PM) and suicide. However, it is unclear that PM exposure and suicide death among major depressive disorder (MDD) patients, a high-risk group for suicide.Methods: We investigated the risk of suicide among 1,046,169 newly-diagnosed MDD patients from 2004 to 2015 within the Korean National Health Insurance Service (NHIS) database. We identified 3,372 suicide cases from January 1, 2015, to December 31, 2017, within the death statistics database of the Korean National Statistical Office. PMs with diameter less than 2.5 μm (PM2.5), less than 10 μm (PM10), and 2.5 μm to 10 μm (PM2.5-10) were considered, which were provided from the National Ambient Air Monitoring System in South Korea. Time-stratified case-crossover analysis was performed to investigate the association of particulate matter exposure to suicide events.Results: The risk of suicide was significantly high upon the high level of exposure to PM2.5-10, PM10 on lag 1 (p for trend = 0.044, 0.035, respectively). A similar association was observed in the multi-day lag model (lag 0-3). Increasing exposure to PM 2.5 was not associated with increased suicide risk.Conclusions: Short-term exposure to a high level of PM2.5-10 and PM10 was associated with an elevated risk for suicide among MDD patients, while PM2.5 did not. There is a clear dose-response relationship between short-term coarse particle exposures with suicide death among Major Depressive Disorder patients. This result will be used as an essential basis for consideration when establishing an air pollution alarm system and implementing a suicide prevention program for reducing adverse health outcomes by PM.

scholarly journals Associations Between Long‐Term Fine Particulate Matter Exposure and Mortality in Heart Failure Patients

2020 ◽  
Vol 9 (6) ◽  
Author(s):  
Cavin K. Ward‐Caviness ◽  
Anne M. Weaver ◽  
Matthew Buranosky ◽  
Emily R. Pfaff ◽  
Lucas M. Neas ◽  
...  
Keyword(s):  
Heart Failure ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Heart Failure Patients ◽  
Fine Particulate ◽  
Particulate Matter Exposure

scholarly journals Long-Term Fine Particulate Matter Exposure and Mortality From Diabetes in Canada

Diabetes Care ◽  
2013 ◽  
Vol 36 (10) ◽  
pp. 3313-3320 ◽  
Author(s):  
R. D. Brook ◽  
S. Cakmak ◽  
M. C. Turner ◽  
J. R. Brook ◽  
D. L. Crouse ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Fine Particulate ◽  
Particulate Matter Exposure

scholarly journals Fine Particulate Matter and Markers of Alzheimer’s Disease Neuropathology at Autopsy in a Community-Based Cohort

2021 ◽  
Vol 79 (4) ◽  
pp. 1761-1773
Author(s):  
Rachel M. Shaffer ◽  
Ge Li ◽  
Sara D. Adar ◽  
C. Dirk Keene ◽  
Caitlin S. Latimer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Braak Stage ◽  
Community Based ◽  
Spatiotemporal Model ◽  
Fine Particulate ◽  
Autopsy Specimens

Background: Evidence links fine particulate matter (PM2.5) to Alzheimer’s disease (AD), but no community-based prospective cohort studies in older adults have evaluated the association between long-term exposure to PM2.5 and markers of AD neuropathology at autopsy. Objective: Using a well-established autopsy cohort and new spatiotemporal predictions of air pollution, we evaluated associations of 10-year PM2.5 exposure prior to death with Braak stage, Consortium to Establish a Registry for AD (CERAD) score, and combined AD neuropathologic change (ABC score). Methods: We used autopsy specimens (N = 832) from the Adult Changes in Thought (ACT) study, with enrollment ongoing since 1994. We assigned long-term exposure at residential address based on two-week average concentrations from a newly developed spatiotemporal model. To account for potential selection bias, we conducted inverse probability weighting. Adjusting for covariates with tiered models, we performed ordinal regression for Braak and CERAD and logistic regression for dichotomized ABC score. Results: 10-year average (SD) PM2.5 from death across the autopsy cohort was 8.2 (1.9) μg/m3. Average age (SD) at death was 89 (7) years. Each 1μg/m3 increase in 10-year average PM2.5 prior to death was associated with a suggestive increase in the odds of worse neuropathology as indicated by CERAD score (OR: 1.35 (0.90, 1.90)) but a suggestive decreased odds of neuropathology as defined by the ABC score (OR: 0.79 (0.49, 1.19)). There was no association with Braak stage (OR: 0.99 (0.64, 1.47)). Conclusion: We report inconclusive associations between PM2.5 and AD neuropathology at autopsy among a cohort where 94% of individuals experienced 10-year exposures below the current EPA standard. Prior studies of AD risk factors and AD neuropathology are similarly inconclusive, suggesting alternative mechanistic pathways for disease or residual confounding.

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