scholarly journals Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts

2017 ◽  
Vol 125 (11) ◽  
pp. 117004 ◽  
Author(s):  
Nuria Matilla-Santander ◽  
Damaskini Valvi ◽  
Maria-Jose Lopez-Espinosa ◽  
Cyntia B. Manzano-Salgado ◽  
Ferran Ballester ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Perfluoroalkyl Substances ◽  
Birth Cohorts ◽  
Metabolic Outcomes

scholarly journals Perfluoroalkyl substances and lipid profile in exposed pregnant women in the Veneto Region, Italy

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
T Dalla Zuanna ◽  
G Barbieri ◽  
G Pitter ◽  
M Zare Jeddi ◽  
F Daprà ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Plasma Concentrations ◽  
Density Lipoprotein ◽  
Additive Models ◽  
Lipoprotein Cholesterol ◽  
Perfluoroalkyl Substances ◽  
Surveillance Program ◽  
Veneto Region ◽  
Exposed Population

Abstract Background Perfluoroalkyl substances (PFASs) are persistent and widespread environmental pollutants. Residents of a large area of the Veneto Region (North-Eastern Italy) were exposed to high concentrations of PFASs through drinking water from the late-1970s to 2013. PFASs have been consistently associated with raised serum lipids, but only few studies have been conducted among pregnant women, and none has stratified analyses by trimesters of gestation. Our main objective was to evaluate the association between perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) levels and lipid profiles in high-exposed pregnant women. Methods A cross-sectional analysis was conducted in 319 pregnant women (age 14-48 years) recruited in the Regional health surveillance program. Serum PFASs were measured by HPLC-MS/MS. Non-fasting serum total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were measured by enzymatic assays in automated analysers, and low-density lipoprotein cholesterol (LDL-C) was calculated. The associations between ln-transformed PFASs (and categorized into quartiles) and lipids were assessed using generalized additive models. Analyses were adjusted for potential confounders and stratified according to pregnancy trimester. Results In the first trimester, plasma concentrations of both PFOA and PFOS were positively associated with TC. However in the third trimester PFOA levels were instead inversely significantly associated with TC and LDL-C levels. Overall, both PFOA and PFOS were positively associated with HDL-C, and PFOA negatively with LDL-C. Conclusions In a small highly exposed population of pregnant women, the associations between PFASs concentrations and lipid profile were modified by trimester of gestation. Patterns late in pregnancy were different to the positive associations with LDL-C generally found. Differential transfer and bioaccumulation of lipids and PFAS in the placenta across gestation might explain our findings. Key messages This study provides evidence of different patterns of PFAS associations with lipids in pregnant women across the trimesters of gestation. The different patterns of association from general population studies sheds light on the role of fetal nutrition during pregnancy affecting both lipids and PFAS in serum.

scholarly journals The association between perfluoroalkyl substances and lipid profile in exposed pregnant women in the Veneto region, Italy

2021 ◽  
Vol 209 ◽  
pp. 111805
Author(s):  
Teresa Dalla Zuanna ◽  
David A. Savitz ◽  
Giulia Barbieri ◽  
Gisella Pitter ◽  
Maryam Zare Jeddi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Perfluoroalkyl Substances ◽  
Veneto Region

scholarly journals Concentrations of perfluoroalkyl substances in foods and the dietary exposure among Taiwan general population and pregnant women

2018 ◽  
Vol 26 (3) ◽  
pp. 994-1004 ◽  
Author(s):  
Wen-Ling Chen ◽  
Fang-Yu Bai ◽  
Ying-Chia Chang ◽  
Pau-Chung Chen ◽  
Chia-Yang Chen
Keyword(s):  
General Population ◽  
Pregnant Women ◽  
Dietary Exposure ◽  
Perfluoroalkyl Substances

Exposure to perfluoroalkyl substances was associated with estrogen homeostasis in pregnant women

2021 ◽  
pp. 150360
Author(s):  
Jiaqi Yang ◽  
Hexing Wang ◽  
Hongyi Du ◽  
Hongji Fang ◽  
Minghui Han ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Perfluoroalkyl Substances

scholarly journals Shifting Global Exposures to Poly- and Perfluoroalkyl Substances (PFASs) Evident in Longitudinal Birth Cohorts from a Seafood-Consuming Population

2018 ◽  
Vol 52 (6) ◽  
pp. 3738-3747 ◽  
Author(s):  
Clifton Dassuncao ◽  
Xindi C. Hu ◽  
Flemming Nielsen ◽  
Pál Weihe ◽  
Philippe Grandjean ◽  
...  
Keyword(s):  
Perfluoroalkyl Substances ◽  
Birth Cohorts

The effects of gut microbiota on metabolic outcomes in pregnant women and their offspring

2018 ◽  
Vol 9 (9) ◽  
pp. 4537-4547 ◽  
Author(s):  
You Lv ◽  
Zi Yan ◽  
Xue Zhao ◽  
Xiaokun Gang ◽  
Guangyu He ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gut Microbiota ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Metabolic Diseases ◽  
Health Issues ◽  
Metabolic Outcomes

Metabolic diseases such as gestational diabetes mellitus and obesity during pregnancy have become severe health issues due to adverse pregnant outcomes in recent years.

scholarly journals Assessing the relationship between perfluoroalkyl substances, thyroid hormones and binding proteins in pregnant women; a longitudinal mixed effects approach

2015 ◽  
Vol 77 ◽  
pp. 63-69 ◽  
Author(s):  
Vivian Berg ◽  
Therese Haugdahl Nøst ◽  
Solrunn Hansen ◽  
Astrid Elverland ◽  
Anna-Sofía Veyhe ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Pregnant Women ◽  
Binding Proteins ◽  
Mixed Effects ◽  
Perfluoroalkyl Substances ◽  
The Relationship

scholarly journals Maternal Diet and the Serum Metabolome in Pregnancy: Robust Dietary Biomarkers Generalizable to a Multiethnic Birth Cohort

2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Russell J de Souza ◽  
Meera Shanmuganathan ◽  
Amel Lamri ◽  
Stephanie A Atkinson ◽  
Allan Becker ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Birth Cohort ◽  
Diet Quality ◽  
Hippuric Acid ◽  
Maternal Diet ◽  
Birth Cohorts ◽  
Cross Sectional ◽  
Serum Metabolites ◽  
Dietary Biomarkers ◽  
Specific Serum

ABSTRACT Background Advances in metabolomics are anticipated to decipher associations between dietary exposures and health. Replication biomarker studies in different populations are critical to demonstrate generalizability. Objectives To identify and validate robust serum metabolites associated with diet quality and specific foods in a multiethnic cohort of pregnant women. Design In this cross-sectional analysis of 3 multiethnic Canadian birth cohorts, we collected semiquantitative FFQ and serum data from 900 women at the second trimester of pregnancy. We calculated a diet quality score (DQS), defined as daily servings of “healthy” minus “unhealthy” foods. Serum metabolomics was performed by multisegment injection-capillary electrophoresis-mass spectrometry, and specific serum metabolites associated with maternal DQSs were identified. We combined the results across all 3 cohorts using meta-analysis to classify robust dietary biomarkers (r > ± 0.1; P < 0.05). Results Diet quality was higher in the South Asian birth cohort (mean DQS = 7.1) than the 2 white Caucasian birth cohorts (mean DQS <3.2). Sixty-six metabolites were detected with high frequency (>75%) and adequate precision (CV <30%), and 47 were common to all cohorts. Hippuric acid was positively associated with healthy diet score in all cohorts, and with the overall DQS only in the primarily white Caucasian cohorts. We observed robust correlations between: 1) proline betaine—citrus foods; 2) 3-methylhistidine—red meat, chicken, and eggs; 3) hippuric acid—fruits and vegetables; 4) trimethylamine N-oxide (TMAO)—seafood, meat, and eggs; and 5) tryptophan betaine—nuts/legumes. Conclusions Specific serum metabolites reflect intake of citrus fruit/juice, vegetables, animal foods, and nuts/legumes in pregnant women independent of ethnicity, fasting status, and delays to storage across multiple collection centers. Robust biomarkers of overall diet quality varied by cohort. Proline betaine, 3-methylhistidine, hippuric acid, TMAO, and tryptophan betaine were robust dietary biomarkers for investigations of maternal nutrition in diverse populations.

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