scholarly journals Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production.

1995 ◽  
Vol 103 (12) ◽  
pp. 1136-1143 ◽  
Author(s):  
R M Sharpe ◽  
J S Fisher ◽  
M M Millar ◽  
S Jobling ◽  
J P Sumpter
Endocrinology ◽  
1992 ◽  
Vol 131 (2) ◽  
pp. 559-565
Author(s):  
J D Kirby ◽  
A E Jetton ◽  
P S Cooke ◽  
R A Hess ◽  
D Bunick ◽  
...  

1999 ◽  
Vol 39 (5-6) ◽  
pp. 617-624 ◽  
Author(s):  
D. Fernandez-Abella ◽  
D. Becu-Villalobos ◽  
I. M. Lacau-Mengido ◽  
N. Villegas ◽  
O. Bentancur

1995 ◽  
Vol 35 (4) ◽  
pp. 447 ◽  
Author(s):  
CC Pomares ◽  
DB Galloway ◽  
JHG Holmes ◽  
IJ Clarke ◽  
AJ Tilbrook

Lupins and cowpeas were fed at 0.0, 0.5, 1.0, and 2.0% liveweight (LW) to groups of 6 or 7 South Australian Merino rams for 11 weeks as supplements to a maintenance diet of grass hay. Productive and reproductive parameters were examined. Supplementation at all levels of either grain increased (P<0.001) LW, condition score, backfat thickness, and wool growth, with rams showing similar responses when given cowpeas and lupins. The weights of the pancreas of rams decreased (P<0.01) as the levels of supplementation increased. Semen characteristics (volume, concentration, motility, etc.) and response to freezing did not differ between the diets. Feeding either legume increased (P<0.001) testicular size, lupins giving a slightly greater response than cowpeas. Sperm production per g testicular tissue was not significantly altered. Increasing levels of either supplement increased (P<0.001) the weights of the seminal vesicles, more (P<0.01) so with lupins. The same effects occurred with the weight of epididymides except for rams fed cowpeas at the highest level. Histologically, the testes revealed an increase (P<0.001) in the number of round spermatogenic cell nuclei and the cross-sectional diameter of stage 8 tubules in rams after legume grain supplementation at 2.0% LW compared with controls. The response was higher in lupin-fed rams (P<0.05). Plasma luteinising hormone (LH) and follicle stimulating hormone (FSH) were measured in rams fed at maintenance or with lupins or cowpeas at 2.0% LW. Rams responded equally to all legumes. Concentrations of LH in peripheral blood increased (P<0.001) by 140% and FSH concentrations were elevated (P<0.01) 4-fold. Cowpeas, a tropical grain legume similar in nutrient composition to lupins, have similar potential when used as a supplement to improve productive and reproductive capabilities of Merino rams.


Reproduction ◽  
1994 ◽  
Vol 100 (1) ◽  
pp. 315-321 ◽  
Author(s):  
L. Johnson ◽  
G. K. Carter ◽  
D. D. Varner ◽  
T. S. Taylor ◽  
T. L. Blanchard ◽  
...  

1960 ◽  
Vol XXXIV (III) ◽  
pp. 411-429 ◽  
Author(s):  
Melvin J. Fregly ◽  
Kenneth M. Cook

ABSTRACT The anti-thyroid drugs, thiouracil, propylthiouracil, and methimazole, prevented both development of elevated blood pressure and cardiac hypertrophy usually accompanying kidney encapsulation with latex envelopes. These drugs also reduced elevated blood pressure of rats with hypertension of 13 to 40 weeks' duration prior to drug administration. Addition of desiccated thyroid powder to diet containing an anti-thyroid drug overcame the anti-hypertensive effect of the latter. Withdrawal of thyroid powder only was followed by return of blood pressure to previous low level within 3 weeks. The results suggest that the anti-hypertensive effect of these drugs is related directly to the hypothyroidism produced rather than to extrathyroidal effects of the drugs. Comparison of potencies of the 3 drugs in terms of anti-hypertensive effect, inhibition of growth rate, increase in testicular size, and increase in thyroid size suggests that propylthiouracil and methimazole are equally potent per unit weight of drug. Thiouracil has approximately half the potency of the other two.


Author(s):  
Muftau Shittu ◽  
Suleiman Folorunsho Ambali ◽  
Joseph Olusegun Ayo ◽  
Mohammed Umaru Kawu ◽  
Aishat Omobolanle Olatunji

Author(s):  
Danielle Estanislau Coelho Silva ◽  
Jurandy Mauro Penitente-Filho ◽  
Domingos Lollobrigida Souza Neto ◽  
Bruna Waddington ◽  
Renan Reis de Oliveira ◽  
...  

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