scholarly journals In vivo mutations in human blood cells: biomarkers for molecular epidemiology.

1993 ◽  
Vol 99 ◽  
pp. 135-141 ◽  
Author(s):  
R J Albertini ◽  
J A Nicklas ◽  
J C Fuscoe ◽  
T R Skopek ◽  
R F Branda ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Human Blood ◽  
Blood Cells ◽  
Human Blood Cells

The metabolism of α-2′ -deoxythioguanosine in murine tumor cells

1968 ◽  
Vol 46 (7) ◽  
pp. 655-661 ◽  
Author(s):  
G. A. LePage
Keyword(s):  
Cell Growth ◽  
Tumor Cells ◽  
Human Blood ◽  
Blood Cells ◽  
Carcinoma Cells ◽  
Ehrlich Carcinoma ◽  
Human Blood Cells ◽  
Murine Tumor Cells ◽  
Rna And Dna

Preparations of α-2′-deoxythioguanosine (α-TGdR) completely free of β-2′-deoxythioguanosine (β-TGdR) were made and labeled with radiosulfur. A purified preparation of nucleoside phosphorylase obtained from human blood cells was found to be active on the β-anomer but completely inactive on the α-anomer. This property of the enzyme was used to characterize metabolites of α-TGdR. α-TGdR and β-TGdR were both found to be converted to the corresponding mono-, di-, and tri-phosphates and incorporated into the nucleic acids of Mecca lymphosarcoma cells in vivo. α-TGdR appeared predominantly in the terminal nucleoside positions of RNA and DNA. β-TGdR appeared predominantly in the nucleotide chain. Both Mecca lymphosarcoma and Ehrlich carcinoma cells formed significant quantities of analog nucleotides at all three levels of phosphorylation, probably exceeding the levels of guanine nucleotides in the cells for an appreciable time. The findings further support a correlation reported earlier between the incorporation of 6-thioguanine into DNA and the inhibition of cell growth.

DNA-damaging effect of cyclophosphamide on human blood cells in vivo and in vitro studied with the single-cell gel test (comet assay)

1995 ◽  
Vol 25 (3) ◽  
pp. 180-187 ◽  
Author(s):  
Andreas Hartmann ◽  
Kathleen Herkommer ◽  
Michael Glück ◽  
Günter Speit
Keyword(s):  
Comet Assay ◽  
Single Cell ◽  
Human Blood ◽  
Blood Cells ◽  
Human Blood Cells

scholarly journals Imaging human blood cells in vivo with oblique back-illumination capillaroscopy

2020 ◽  
Vol 11 (5) ◽  
pp. 2373 ◽  
Author(s):  
Gregory N. McKay ◽  
Nela Mohan ◽  
Nicholas J. Durr
Keyword(s):  
Human Blood ◽  
Blood Cells ◽  
Human Blood Cells

scholarly journals Biological Effects of Echinacea Purpurea on Human Blood Cells

2009 ◽  
Vol 60 (2) ◽  
pp. 165-172 ◽  
Author(s):  
Gordana Joksić ◽  
Sandra Petrović ◽  
Ivana Joksić ◽  
Andreja Leskovac
Keyword(s):  
Human Blood ◽  
Blood Cells ◽  
Biological Effects ◽  
Echinacea Purpurea ◽  
Adverse Health Effects ◽  
Dicentric Chromosomes ◽  
Human Blood Cells ◽  
Before And After ◽  
Radiation Workers

Biological Effects of Echinacea Purpurea on Human Blood CellsThe aim of this study was to investigate radioprotective properties of Echinacea purpurea tablets in vivo. We analysed lymphocyte chromosome aberrations (CA), micronuclei (MN), apoptosis of leukocytes and haematological parameters in a group of radiation workers who were identified as carrying dicentric chromosomes in their lymphocytes. All radiation workers were taking two 275 mg Echinacea tablets b.i.d., according to a pharmacist's recommendation. All parameters were analysed before and after the two-week treatment. At the end of the treatment lymphocyte CA frequency dropped significantly, and the number of apoptotic cells increased. The inverse lymphocyte-to-granulocyte ratio at the beginning of the study changed to normal at its end. In conclusion, biological effects observed after administration of Echinacea purpurea preparation suggest that it may be beneficial for the prevention of adverse health effects in workers exposed to ionising radiation.

Resonance impedance sensing of human blood cells

2008 ◽  
Vol 145-146 ◽  
pp. 29-36 ◽  
Author(s):  
Siyang Zheng ◽  
Mandheerej S. Nandra ◽  
Chi-Yuan Shih ◽  
Wei Li ◽  
Yu-Chong Tai
Keyword(s):  
Human Blood ◽  
Blood Cells ◽  
Impedance Sensing ◽  
Human Blood Cells
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