scholarly journals Chromosomal aberrations and bone marrow toxicity.

1981 ◽  
Vol 39 ◽  
pp. 23-27 ◽  
Author(s):  
J A Heddle ◽  
M F Salamone
Keyword(s):  
Bone Marrow ◽  
Chromosomal Aberrations ◽  
Bone Marrow Toxicity

Bone marrow toxicity induced by oral benzo[a]pyrene: Protection resides at the level of the intestine and liver

1983 ◽  
Vol 70 (3) ◽  
pp. 390-401 ◽  
Author(s):  
Catherine Legraverend ◽  
David E. Harrison ◽  
Francis W. Ruscetti ◽  
Daniel W. Nebert
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Toxicity

scholarly journals Brahmarasayana protects against Ethyl methanesulfonate or Methyl methanesulfonate induced chromosomal aberrations in mouse bone marrow cells

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Kanive Parashiva Guruprasad ◽  
Advait Subramanian ◽  
Vikram Jeet Singh ◽  
Raghavendra Sudheer Kumar Sharma ◽  
Puthiya Mundyat Gopinath ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chromosomal Aberrations ◽  
Bone Marrow Cells ◽  
Ethyl Methanesulfonate ◽  
Methyl Methanesulfonate ◽  
Mouse Bone Marrow ◽  
Mouse Bone Marrow Cells ◽  
Marrow Cells

scholarly journals تثبيط التغيرات الخلوية الوراثية المستحثة بعقار MMC في الفأر الأبيض باستخدام مستخلصي نبات القريص نوع Urtica pilulifera

2007 ◽  
Vol 1 (1) ◽  
pp. 37-51
Author(s):  
Ismail Kadhum Shubber ◽  
Laith Abdel Hassan ◽  
Saadi Hamad Hilal
Keyword(s):  
Bone Marrow ◽  
Cell Division ◽  
Plant Extract ◽  
Chromosomal Aberrations ◽  
Leaf Extract ◽  
Marrow Cell ◽  
Ethanolic Extract ◽  
Genotoxic Effects ◽  
Control Drug ◽  
Cytogenetic Effects

The aim of this study was to investigate the potency of aquatic & alcoholic extracts of the leaves of Urtica pilulifera plant against mutagenecity of Mitomycine C (MMC) drug in mice.The genotoxic effects of three different concentrations 0.01, 0.1 & 0.5 mg/kg from aqueous or ethanolic extract were tested in mice. 0.01 mg/kg bw from either types of extracts were selected as non-genotoxic in comparison to control. Drug-plant extract interaction was tested using mitotic index & Chromosomal aberrations as bioindicators for detection of the potency of the plant extract in reduction of MMC-induction of cytogenetic effects. Two types of treatments were followed, either plant extracts were given before (2, 4, 6) days, or after (2, 4, 6) days, of treatment with MMC. The results revealed that 0.2 mg/kg of MMC significantly inhibited bone marrow cell division and increased the spontaneous levels of chromosomal aberration up to 20 times. Treatment of mice with aqueous or alcoholoic leaf-extract reduced significantly (p < 0.01) the genotoxic effects of MMC. This reduction was more pronounced in animals which were given the extract after treatment with MMC comparing to its treatment before the MMC exposure. These results indicated that Utrtica pilulifera leaves extract behave as bio-anti mutagen first degree and acting indirectly in the 2nd degree.

Oxyphenbutazone eye ointment

1984 ◽  
Vol 22 (22) ◽  
pp. 88-88
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Toxicity ◽  
Product Licence

We have previously considered oxyphenbutazone eye ointment (Tanderil Eye Ointment).1,2 Recently, the Licensing Authority has withdrawn the product licence for oral oxyphenbutazone because of its bone marrow toxicity.3 Oxyphenbutazone eye ointment is used for treating episcleritis: should its licence also be withdrawn?

Bone Marrow Toxicity in Cancer Treatment

2013 ◽  
pp. 41-43
Author(s):  
Stephan Mose ◽  
Stephan Mose ◽  
Brandon J. Fisher ◽  
Iris Rusu ◽  
Charlie Ma ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cancer Treatment ◽  
Bone Marrow Toxicity
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