scholarly journals The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis

2005 ◽  
Vol 113 (6) ◽  
pp. 675-679 ◽  
Author(s):  
Neil J. MacLusky ◽  
Tibor Hajszan ◽  
Csaba Leranth
Keyword(s):  
Bisphenol A ◽  
Environmental Estrogen ◽  
Hippocampal Synaptogenesis

scholarly journals Early cerebral activities of the environmental estrogen bisphenol A appear to act via the somatostatin receptor subtype sst(2).

2002 ◽  
Vol 110 (suppl 3) ◽  
pp. 397-402 ◽  
Author(s):  
Rosa Maria Facciolo ◽  
Raffaella Alò ◽  
Maria Madeo ◽  
Marcello Canonaco ◽  
Francesco Dessì-Fulgheri
Keyword(s):  
Bisphenol A ◽  
Somatostatin Receptor ◽  
Receptor Subtype ◽  
Environmental Estrogen

Environmental estrogen bisphenol A and autoimmunity

Lupus ◽  
2015 ◽  
Vol 24 (4-5) ◽  
pp. 392-399 ◽  
Author(s):  
I Jochmanová ◽  
Z Lazúrová ◽  
M Rudnay ◽  
I Bačová ◽  
M Mareková ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Environmental Estrogen

Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancy

Life Sciences ◽  
2001 ◽  
Vol 69 (22) ◽  
pp. 2611-2625 ◽  
Author(s):  
Jong-Choon Kim ◽  
Ho-Chul Shin ◽  
Shin-Woo Cha ◽  
Woo-Suk Koh ◽  
Moon-Koo Chung ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Developmental Toxicity ◽  
Environmental Estrogen

scholarly journals Estrogen receptor 1 expression and methylation of Esr1 promoter in mouse fetal prostate mesenchymal cells induced by gestational exposure to bisphenol A or ethinylestradiol

2019 ◽  
Vol 5 (3) ◽  
Author(s):  
Ramji K Bhandari ◽  
Julia A Taylor ◽  
Jennifer Sommerfeld-Sager ◽  
Donald E Tillitt ◽  
William A Ricke ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Bisphenol A ◽  
Oral Contraceptives ◽  
Primary Cultures ◽  
Prostate Gland ◽  
Mesenchymal Cells ◽  
Urogenital Sinus ◽  
Environmental Estrogen ◽  
Mouse Prostate

Abstract Fetal/neonatal environmental estrogen exposures alter developmental programing of the prostate gland causing onset of diseases later in life. We have previously shown in vitro that exposures to 17β-estradiol (E2) and the endocrine disrupting chemical bisphenol A, at concentrations relevant to human exposure, cause an elevation of estrogen receptor α (Esr1) mRNA in primary cultures of fetal mouse prostate mesenchymal cells; a similar result was observed in the fetal rat urogenital sinus. Effects of these chemicals on prostate mesenchyme in vivo are not well understood. Here we show effects in mice of fetal exposure to the estrogenic drug in mixed oral contraceptives, 17α-ethinylestradiol (EE2), at a concentration of EE2 encountered by human embryos/fetuses whose mothers become pregnant while on EE2-containing oral contraceptives, or bisphenol A at a concentration relevant to exposures observed in human fetuses in vivo. Expression of Esr1 was elevated by bisphenol A or EE2 exposures, which decreased the global expression of DNA methyltransferase 3A (Dnmt3a), while methylation of Esr1 promoter was significantly increased. These results show that exposures to the environmental estrogen bisphenol A and drug EE2 cause transcriptional and epigenetic alterations to expression of estrogen receptors in developing prostate mesenchyme in vivo.

Exposure to the environmental estrogen bisphenol A differentially modulated estrogen receptor-α and -β immunoreactivity and mRNA in male mouse testis

Life Sciences ◽  
2003 ◽  
Vol 72 (10) ◽  
pp. 1159-1169 ◽  
Author(s):  
Toshihiro Takao ◽  
Wakako Nanamiya ◽  
Hossein Pournajafi Nazarloo ◽  
Reiko Matsumoto ◽  
Koichi Asaba ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Bisphenol A ◽  
Male Mouse ◽  
Estrogen Receptor Α ◽  
Mouse Testis ◽  
Environmental Estrogen

scholarly journals ACUTE TOXICITY OF BISPHENOL A INDUCED PHENOTYPIC CHANGES ON ZEBRAFISH (DANIO RERIO) DURING EARLY DEVELOPMENT

2018 ◽  
Vol 54 (2A) ◽  
pp. 71 ◽  
Author(s):  
Ngo Thi Mai
Keyword(s):  
Bisphenol A ◽  
Early Development ◽  
Danio Rerio ◽  
Aquatic Organisms ◽  
Cellular Responses ◽  
Relevant Information ◽  
Ecological Impacts ◽  
Environmental Estrogen ◽  
Phenotypic Analysis ◽  
Cardiac Edema

Bisphenol A (BPA) has been considered as a weak environmental estrogen, as similar to estradiol that has a potential in stimulating some cellular responses and phenotype changes. In addition, the ecological impacts of BPA to aquatic organisms have been increasingly raised at environmental relevant concentrations that potentially may affect to human health at early–life. This study used 3-day old zebrafish larvae (Danio rerio) as a model for toxicological testing. The semistatic testing was conducted to investigate the effects of different BPA concentrations (5 mg/L, 6 mg/L, 7 mg/L, 8 mg/L and 9 mg/L) that induced morphorlogical and physiological changes during the early development. As the results, the LC50-24hrs, LC50-48hrs, LC50-72hrs and LC50-96hrs were determined as 9.503 mg/L, 8.688 mg/L, 7.328 mg/L and 6.669 mg/L, respectively. Phenotypic analysis revealed that toxicity caused cardiac edema. The result obtained from this research provided relevant information for environmental and human risk assessments.

Sign in / Sign up

Export Citation Format

Share Document