scholarly journals Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure.

2004 ◽  
Vol 112 (3) ◽  
pp. 295-301 ◽  
Author(s):  
Armando Meyer ◽  
Frederic J Seidler ◽  
Justin E Aldridge ◽  
Charlotte A Tate ◽  
Mandy M Cousins ◽  
...  
Keyword(s):  
Adenylyl Cyclase ◽  
Rat Brain ◽  
Brain Regions ◽  
Developmental Neurotoxicity ◽  
Neonatal Exposure ◽  
Critical Periods ◽  
Adult Rat ◽  
Rat Brain Regions ◽  
Adult Rat Brain

Developmental neurotoxicity of cadmium on enzyme activities of crucial offspring rat brain regions

BioMetals ◽  
2013 ◽  
Vol 26 (6) ◽  
pp. 1013-1021 ◽  
Author(s):  
Vasileios Stolakis ◽  
Stylianos Tsakiris ◽  
Konstantinos Kalafatakis ◽  
Apostolos Zarros ◽  
Nikolina Skandali ◽  
...  
Keyword(s):  
Rat Brain ◽  
Enzyme Activities ◽  
Brain Regions ◽  
Developmental Neurotoxicity ◽  
Rat Brain Regions

scholarly journals Monoubiquitination and Cellular Distribution of XIAP in Neurons after Traumatic Brain Injury

2003 ◽  
Vol 23 (10) ◽  
pp. 1129-1136 ◽  
Author(s):  
George Lotocki ◽  
Ofelia F Alonso ◽  
Beata Frydel ◽  
W Dalton Dietrich ◽  
Robert W Keane
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Rat Brain ◽  
Brain Regions ◽  
Normal Adult ◽  
Normal Brain ◽  
Adult Rat ◽  
Moderate Traumatic Brain Injury ◽  
Adult Rat Brain ◽  
Specific Regulation

XIAP is a member of the inhibitor of apoptosis (IAP) gene family that, in addition to suppressing cell death by inhibition and polyubiquitination of caspases, is involved in an increasing number of signaling cascades. Moreover, the function and regulation of XIAP in the central nervous system (CNS) is poorly understood. In this study, the authors investigated the cell-type expression, the subcellular distribution, ubiquitination of XIAP, and levels of Smac/DIABLO in the normal adult rat brain and in brains subjected to moderate traumatic brain injury (TBI). In the normal brain, XIAP was predominantly expressed in the perinuclear region of neurons. Traumatized brains showed dramatic alterations in cellular and regional expression of XIAP early after injury. Stereologic analyses of the number of XIAP-positive cells within the hippocampus of both hemispheres showed a biphasic response. Immunoprecipitation and immunoblots of extracts derived from different brain regions demonstrated that a single ubiquitin modifies XIAP. Normal cortex contained significantly higher levels of monoubiquitinated XIAP than hippocampus. TBI induced alterations in levels of monoubiquitinated XIAP that correlated with changes in XIAP distribution and immunoreactivity, suggesting that monoubiquitination of XIAP may be a regulator of XIAP location or activity. Similar levels of Smac/DIABLO were present in lysates of normal and traumatized brains. These data demonstrate for the first time a region-specific regulation of XIAP monoubiquitination in the normal adult rat brain, and after TBI, that may be a key event in the regulation of XIAP function contributing to the pathogenesis following injury.

Increasedα2-adrenoceptor mediated regulation of adult rat brain noradrenaline overflow after chronic neonatal exposure to propranolol; a microdialysis study

1994 ◽  
Vol 646 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Marjan J.A. van Veldhuizen ◽  
Matthijs G.P. Feenstra ◽  
Margriet H.A. Botterblom ◽  
Gerald J. Boer
Keyword(s):  
Rat Brain ◽  
Neonatal Exposure ◽  
Adult Rat ◽  
Adult Rat Brain ◽  
Brain Noradrenaline ◽  
Microdialysis Study

scholarly journals Dopaminergic neuronal injury in the adult rat brain following neonatal exposure to lipopolysaccharide and the silent neurotoxicity

2011 ◽  
Vol 25 (2) ◽  
pp. 286-297 ◽  
Author(s):  
Lir-Wan Fan ◽  
Lu-Tai Tien ◽  
Baoying Zheng ◽  
Yi Pang ◽  
Rick C.S. Lin ◽  
...  
Keyword(s):  
Rat Brain ◽  
Neuronal Injury ◽  
Neonatal Exposure ◽  
Adult Rat ◽  
Adult Rat Brain
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