scholarly journals Long-term neurobehavioral health effects of methyl parathion exposure in children in Mississippi and Ohio.

2004 ◽  
Vol 112 (1) ◽  
pp. 46-51 ◽  
Author(s):  
Perri Zeitz Ruckart ◽  
Kirsten Kakolewski ◽  
Frank J Bove ◽  
Wendy E Kaye
Keyword(s):  
Health Effects ◽  
Methyl Parathion

scholarly journals Long-Term Exposure to Nanosized TiO2 Triggers Stress Responses and Cell Death Pathways in Pulmonary Epithelial Cells

2021 ◽  
Vol 22 (10) ◽  
pp. 5349
Author(s):  
Mayes Alswady-Hoff ◽  
Johanna Samulin Erdem ◽  
Santosh Phuyal ◽  
Oskar Knittelfelder ◽  
Animesh Sharma ◽  
...  
Keyword(s):  
Cell Death ◽  
Epithelial Cells ◽  
Health Effects ◽  
Stress Responses ◽  
Cell Stress ◽  
Lipid Classes ◽  
Long Term Effects ◽  
Cell Death Pathways ◽  
Pulmonary Epithelial Cells

There is little in vitro data available on long-term effects of TiO2 exposure. Such data are important for improving the understanding of underlying mechanisms of adverse health effects of TiO2. Here, we exposed pulmonary epithelial cells to two doses (0.96 and 1.92 µg/cm2) of TiO2 for 13 weeks and effects on cell cycle and cell death mechanisms, i.e., apoptosis and autophagy were determined after 4, 8 and 13 weeks of exposure. Changes in telomere length, cellular protein levels and lipid classes were also analyzed at 13 weeks of exposure. We observed that the TiO2 exposure increased the fraction of cells in G1-phase and reduced the fraction of cells in G2-phase, which was accompanied by an increase in the fraction of late apoptotic/necrotic cells. This corresponded with an induced expression of key apoptotic proteins i.e., BAD and BAX, and an accumulation of several lipid classes involved in cellular stress and apoptosis. These findings were further supported by quantitative proteome profiling data showing an increase in proteins involved in cell stress and genomic maintenance pathways following TiO2 exposure. Altogether, we suggest that cell stress response and cell death pathways may be important molecular events in long-term health effects of TiO2.

scholarly journals Contamination of food with cadmium and dioxins – influence on the human body

2019 ◽  
Vol 65 (3) ◽  
Author(s):  
Aleksandra Słojewska ◽  
Izabela Gutowska
Keyword(s):  
General Population ◽  
Health Effects ◽  
Human Body ◽  
Bone Mineralization ◽  
The Body ◽  
Food Sources ◽  
Hormonal Balance ◽  
Small Doses ◽  
Contaminated Food

Introduction: Food is a carrier of many pollutants nowadays. For cadmium and dioxins, it is the main source of these compounds in the general population. Hence, the aim of this work was to collect data on the health effects associated with exposure to cadmium and dioxins which get into the human body through food.Materials and methods: A literature review was conducted by searching the scientific Medline database (PubMed) and Google Scholar.Results: Health effects associated with a long-term exposure to low doses of cadmium and dioxins may be nonspecific and are rarely attributed to food sources. These may cause disorders affecting hormonal balance, kidney function, lipid metabolism, fertility, cognitive function, bone mineralization, and susceptibility to diseases and allergies. These compounds may also lead to cancer development.Conclusions: The general population faces the problem of longterm exposure to small doses of these substances due to their accumulation in the body, even if their amounts do not exceed the relevant standards. The health effects of this type of exposure may be significantly delayed and are not likely to be attributed to the consumption of contaminated food. Consumers wishing to reduce the amounts of these compounds delivered to the body should limit the consumption of grilled and smoked products, and should also opt for organic food.

scholarly journals Microplastics - an emerging silent menace to public health

2021 ◽  
Vol 5 (10) ◽  
Author(s):  
Li-Yin Pang ◽  
Shola Sonagara ◽  
Oreoluwatomide Oduwole ◽  
Christopher Gibbins ◽  
Ting Kang Nee
Keyword(s):  
Public Health ◽  
Health Effects ◽  
Mammalian Cells ◽  
Circulatory System ◽  
Epidemiological Studies ◽  
Specific Effects ◽  
Important Pathway ◽  
Living Organisms ◽  
Respiratory Conditions

Over the past few decades, microplastics have become increasingly ubiquitous in the environment and now contaminate the bodies of many living organisms, including humans. Microplastics, as defined here, are plastics within the size range 0.1 μm and 5 mm and are a worrying form of pollution due to public health concerns. This mini-review aims to summarise the route of entry of microplastics into humans and explore the potential detrimental health effects of microplastics. Trophic transfer is an important pathway for microplastic to be transferred across different groups of organisms, with ingestion is regarded as one of the major routes of exposure for humans. Other pathways include inhalation and dermal contact. The health consequences of microplastics manifest because these materials can translocate into the circulatory system and accumulate in the lungs, liver, kidney, and even brain, regardless of the route of entry. Health effects include gastrointestinal disturbances such as inflammation and gut microbiota disruption, respiratory conditions, neurotoxicity and potential cancers. Overall, while it is apparent that microplastics are causing adverse effects on different biological groups and ecosystems, current research is largely focused on marine organisms and aquaculture. Therefore, more studies are needed to investigate specific effects in mammalian cells and tissues, with more long-term epidemiological studies needed on human population considered to be at high-risk due to socioeconomic or other circumstance. Knowledge of the toxicity and long-term health impacts of microplastics is currently limited and requires urgent attention.

scholarly journals Medical and health surveillance in postaccident recovery: experience after Fukushima

2018 ◽  
Vol 47 (3-4) ◽  
pp. 229-240 ◽  
Author(s):  
K. Tanigawa
Keyword(s):  
Radiation Exposure ◽  
Health Effects ◽  
Large Scale ◽  
Social Issues ◽  
Well Being ◽  
Health Problems ◽  
Health Surveillance ◽  
Fukushima Accident ◽  
Difficult Situation

The accident at Fukushima Daiichi nuclear power plant occurred following the huge tsunami and earthquake of 11 March 2011. After the accident, there was considerable uncertainty and concern about the health effects of radiation. In this difficult situation, emergency responses, including large-scale evacuation, were implemented. The Fukushima Health Management Survey (FHMS) was initiated 3 months after the accident. The primary purposes of FHMS were to monitor the long-term health of residents, promote their well-being, and monitor any health effects related to long-term, low-dose radiation exposure. Despite the severity of the Fukushima accident and the huge impact of the natural disaster, radiation exposure of the public was very low. However, there were other serious health problems, including deaths during evacuation, increased mortality among displaced elderly people, mental health and lifestyle-related health problems, and social issues after the accident. The Nuclear Emergency Situations – Improvement of Medical and Health Surveillance (SHAMISEN) project, funded by the Open Project For European Radiation Research Area, aimed to develop recommendations for medical and health surveillance of populations affected by previous and future radiation accidents. This paper briefly introduces the points that have been learned from the Fukushima accident from the perspective of SHAMISEN recommendations.

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