scholarly journals Cancer Incidence in World Trade Center Rescue and Recovery Workers, 2001–2008

2013 ◽  
Vol 121 (6) ◽  
pp. 699-704 ◽  
Author(s):  
Samara Solan ◽  
Sylvan Wallenstein ◽  
Moshe Shapiro ◽  
Susan L. Teitelbaum ◽  
Lori Stevenson ◽  
...  
Keyword(s):  
Cancer Incidence ◽  
World Trade ◽  
World Trade Center ◽  
Trade Center

scholarly journals Temporal Association of Cancer Incidence with World Trade Center Rescue/Recovery Work

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
David G. Goldfarb ◽  
Paolo Boffetta ◽  
Rachel Zeig-Owens ◽  
Dana Kristjansson ◽  
Jiehui Li ◽  
...  
Keyword(s):  
Cancer Incidence ◽  
World Trade ◽  
World Trade Center ◽  
Temporal Association ◽  
Trade Center

scholarly journals Ten-year cancer incidence in rescue/recovery workers and civilians exposed to the September 11, 2001 terrorist attacks on the World Trade Center

2016 ◽  
Vol 59 (9) ◽  
pp. 709-721 ◽  
Author(s):  
Jiehui Li ◽  
Robert M. Brackbill ◽  
Tim S. Liao ◽  
Baozhen Qiao ◽  
James E. Cone ◽  
...  
Keyword(s):  
Cancer Incidence ◽  
World Trade ◽  
World Trade Center ◽  
September 11 ◽  
Terrorist Attacks ◽  
The World ◽  
Trade Center

scholarly journals Cancer Incidence in World Trade Center Rescue and Recovery Workers: 14 Years of Follow-Up

2021 ◽  
Author(s):  
Jiehui Li ◽  
Janette Yung ◽  
Baozhen Qiao ◽  
Erin Takemoto ◽  
David G Goldfarb ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Cancer Incidence ◽  
World Trade ◽  
Cox Regression ◽  
World Trade Center ◽  
Cancer Registries ◽  
Increased Risk ◽  
Long Term Follow Up ◽  
Trade Center

Abstract Background Statistically significantly increased cancer incidence has been reported from 3 cohorts of World Trade Center (WTC) disaster rescue and recovery workers. We pooled data across these cohorts to address ongoing public concerns regarding cancer risk 14 years after WTC exposure. Methods From a combined deduplicated cohort of 69 102 WTC rescue and recovery workers, a sample of 57 402 workers enrolled before 2009 and followed through 2015 was studied. Invasive cancers diagnosed in 2002-2015 were identified from 13 state cancer registries. Standardized incidence ratios (SIRs) were used to assess cancer incidence. Adjusted hazard ratios (aHRs) were estimated from Cox regression to examine associations between WTC exposures and cancer risk. Results Of the 3611 incident cancers identified, 3236 were reported as first-time primary (FP) cancers, with an accumulated 649 724 and 624 620 person-years of follow-up, respectively. Incidence for combined FP cancers was below expectation (SIR = 0.96, 95% confidence interval [CI] = 0.93 to 0.99). Statistically significantly elevated SIRs were observed for melanoma-skin (SIR = 1.43, 95% CI = 1.24 to 1.64), prostate (SIR = 1.19, 95% CI = 1.11 to 1.26), thyroid (SIR = 1.81, 95% CI = 1.57 to 2.09), and tonsil (SIR = 1.40, 95% CI = 1.00 to 1.91) cancer. Those arriving on September 11 had statistically significantly higher aHRs than those arriving after September 17, 2001, for prostate (aHR = 1.61, 95% CI = 1.33 to 1.95) and thyroid (aHR = 1.77, 95% CI = 1.11 to 2.81) cancers, with a statistically significant exposure-response trend for both. Conclusions In the largest cohort of 9/11 rescue and recovery workers ever studied, overall cancer incidence was lower than expected, and intensity of WTC exposure was associated with increased risk for specific cancer sites, demonstrating the value of long-term follow-up studies after environmental disasters.

scholarly journals Cancer incidence in World Trade Center-exposed and non-exposed male firefighters, as compared with the US adult male population: 2001–2016

2021 ◽  
pp. oemed-2021-107570
Author(s):  
Mayris P Webber ◽  
Ankura Singh ◽  
Rachel Zeig-Owens ◽  
Joke Salako ◽  
Molly Skerker ◽  
...  
Keyword(s):  
New York ◽  
Cancer Incidence ◽  
World Trade ◽  
World Trade Center ◽  
Fire Department ◽  
Cancer Registries ◽  
Smoking History ◽  
Health Study ◽  
Male Population ◽  
Trade Center

ObjectiveTo compare cancer incidence in Fire Department of the City of New York (FDNY) firefighters who worked at the World Trade Center (WTC) site to incidence in a population of non-WTC-exposed firefighters, the Career Firefighter Health Study (CFHS) cohort, and to compare rates from each firefighter cohort to rates in demographically similar US males.MethodsFDNY (N=10 786) and CFHS (N=8813) cohorts included male firefighters who were active on 11 September 2001 (9/11) and were followed until death or 31 December 2016. Cases were identified from 15 state cancer registries. Poisson regression models assessed cancers in each group (FDNY and CFHS) versus US males, and associations between group and cancer rates; these models estimated standardised incidence ratios (SIRs) and adjusted relative rates (RRs), respectively. Secondary analyses assessed surveillance bias and smoking history.ResultsWe identified 915 cancer cases in 841 FDNY firefighters and 1002 cases in 909 CFHS firefighters. FDNY had: higher rates for all cancers (RR=1.13; 95% CI 1.02 to 1.25), prostate (RR=1.39; 95% CI 1.19 to 1.63) and thyroid cancer (RR=2.53; 95% CI 1.37 to 4.70); younger median ages at diagnosis (55.6 vs 59.4; p<0.001, all cancers); and more cases with localised disease when compared with CFHS. Compared with US males, both firefighter cohorts had elevated SIRs for prostate cancer and melanoma. Control for surveillance bias in FDNY reduced most differences.ConclusionsExcess cancers occurred in WTC-exposed firefighters relative to each comparison group, which may partially be explained by heightened surveillance. Two decades post-9/11, clearer understanding of WTC-related risk requires extended follow-up and modelling studies (laboratory or animal based) to identify workplace exposures in all firefighters.

scholarly journals Cancer in General Responders Participating in World Trade Center Health Programs, 2003–2013

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Moshe Z Shapiro ◽  
Sylvan R Wallenstein ◽  
Christopher R Dasaro ◽  
Roberto G Lucchini ◽  
Henry S Sacks ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Incidence ◽  
World Trade ◽  
Health Program ◽  
World Trade Center ◽  
September 11 ◽  
Cox Proportional Hazards ◽  
Cancer Case ◽  
Trade Center

Abstract Background Following the September 11, 2001, attacks on the World Trade Center (WTC), thousands of workers were exposed to an array of toxins known to cause adverse health effects, including cancer. This study evaluates cancer incidence in the WTC Health Program General Responder Cohort occurring within 12 years post exposure. Methods The study population consisted of 28 729 members of the General Responder Cohort enrolled from cohort inception, July 2002 to December 31, 2013. Standardized incidence ratios (SIRs) were calculated with cancer case inclusion and follow-up starting post September 11, 2001 (unrestricted) and, alternatively, to account for selection bias, with case inclusion and follow-up starting 6 months after enrollment in the WTC Health Program (restricted). Case ascertainment was based on linkage with six state cancer registries. Under the restricted criterion, hazard ratios were estimated using multivariable Cox proportional hazards models for all cancer sites combined and for prostate cancer. Results Restricted analyses identified 1072 cancers in 999 responders, with elevations in cancer incidence for all cancer sites combined (SIR = 1.09, 95% confidence interval [CI] = 1.02 to 1.16), prostate cancer (SIR = 1.25, 95% CI = 1.11 to 1.40), thyroid cancer (SIR = 2.19, 95% CI = 1.71 to 2.75), and leukemia (SIR = 1.41, 95% CI = 1.01 to 1.92). Cancer incidence was not associated with any WTC exposure index (composite or individual) for all cancer sites combined or for prostate cancer. Conclusion Our analyses show statistically significant elevations in cancer incidence for all cancer sites combined and for prostate and thyroid cancers and leukemia. Multivariable analyses show no association with magnitude or type of exposure.

NYPD Cancer Incidence Rates 1995–2014 Encompassing the Entire World Trade Center Cohort

2015 ◽  
Vol 57 (10) ◽  
pp. e101-e113 ◽  
Author(s):  
Eli J. Kleinman ◽  
Paul J. Christos ◽  
Linda M. Gerber ◽  
John P. Reilly ◽  
William F. Moran ◽  
...  
Keyword(s):  
Cancer Incidence ◽  
World Trade ◽  
World Trade Center ◽  
Incidence Rates ◽  
Trade Center ◽  
Entire World ◽  
Cancer Incidence Rates

scholarly journals Risk factors for incident prostate cancer in a cohort of world trade center responders

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Sean A. P. Clouston ◽  
Peifen Kuan ◽  
Roman Kotov ◽  
Soumyadeep Mukherjee ◽  
Patricia Thompson-Carino ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Incidence ◽  
World Trade ◽  
Proportional Hazards ◽  
Traumatic Event ◽  
World Trade Center ◽  
Cox Proportional Hazards ◽  
Stressful Events ◽  
Prostate Cancer Incidence ◽  
Trade Center

Abstract Background Despite a relatively young average age and no routine screening, prostate cancer is one of the most common cancers in men who worked at the World Trade Center (WTC) following the 9/11/2001 disaster. This study evaluated whether re-experiencing stressful memories of a traumatic event was associated with prostate cancer incidence. Methods Participants were males from one clinical center that monitors the health of first-responders (N = 6857). Monitoring began in July 2002 and occurs annually but does not include prostate cancer screening. Severity of physical exposures and of re-experiencing memories and stress responses were measured at study enrollment using standardized and validated methods in all participants. The outcome was incidence of diagnosed prostate cancer after enrollment (n = 68). Bivariate analyses provided age-adjusted incidence rates (aIR). Cox proportional hazards modeling was used to calculate incidence; hazards ratios (HR) were reported. Results The mean age of responders on 9/11/2001 was 37.9 years. Prostate cancer incidence was lowest in responders with no re-experiencing stress (aIR = 250.83/100,000 person-years, [233.41–268.25]) and highest in responders with severe re-experiencing stress (aIR = 818.49/100,000 person-years, [801.07–835.91]). Cox proportional hazards regression revealed that re-experiencing the stressful events of 9/11/2001 was associated with increased prostate cancer incidence (HR = 1.96 [1.26–3.05], P = 0.003), even upon adjusting for confounders. Conclusions This is the first study to identify a positive association between re-experiencing a traumatic event and prostate cancer incidence. Our results are consistent with recent rodent model evidence demonstrating a direct biological link between stress pathways and prostate tumorigenesis and offer new hypotheses in the causality of prostate cancer.

Sign in / Sign up

Export Citation Format

Share Document