scholarly journals Retracted: G-Protein–Coupled Receptor 30 and Estrogen Receptor-α Are Involved in the Proliferative Effects Induced by Atrazine in Ovarian Cancer Cells

2008 ◽  
Vol 116 (12) ◽  
pp. 1648-1655 ◽  
Author(s):  
Lidia Albanito ◽  
Rosamaria Lappano ◽  
Antonio Madeo ◽  
Adele Chimento ◽  
Eric R. Prossnitz ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
G Protein ◽  
Estrogen Receptor Α ◽  
Ovarian Cancer Cells ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals The G-Protein-Coupled Estrogen Receptor (GPER) Regulates Trimethylation of Histone H3 at Lysine 4 and Represses Migration and Proliferation of Ovarian Cancer Cells In Vitro

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 619
Author(s):  
Nan Han ◽  
Sabine Heublein ◽  
Udo Jeschke ◽  
Christina Kuhn ◽  
Anna Hester ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Estrogen Receptor ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cancer Patients ◽  
G Protein ◽  
Histone H3 ◽  
Ovarian Cancer Cells ◽  
G Protein Coupled

Histone H3 lysine 4 trimethylation (H3K4me3) is one of the most recognized epigenetic regulators of transcriptional activity representing, an epigenetic modification of Histone H3. Previous reports have suggested that the broad H3K4me3 domain can be considered as an epigenetic signature for tumor-suppressor genes in human cells. G-protein-coupled estrogen receptor (GPER), a new membrane-bound estrogen receptor, acts as an inhibitor on cell growth via epigenetic regulation in breast and ovarian cancer cells. This study was conducted to evaluate the relationship of GPER and H3K4me3 in ovarian cancer tissue samples as well as in two different cell lines (Caov3 and Caov4). Silencing of GPER by a specific siRNA and two selective regulators with agonistic (G1) and antagonistic (G15) activity were applied for consecutive in vitro studies to investigate their impacts on tumor cell growth and the changes in phosphorylated ERK1/2 (p-ERK1/2) and H3K4me3. We found a positive correlation between GPER and H3K4me3 expression in ovarian cancer patients. Patients overexpressing GPER as well as H3K4me3 had significantly improved overall survival. Increased H3K4me3 and p-ERK1/2 levels and attenuated cell proliferation and migration were observed in Caov3 and Caov4 cells via activation of GPER by G1. Conversely, antagonizing GPER activity by G15 resulted in opposite effects in the Caov4 cell line. In conclusion, interaction of GPER and H3K4me3 appears to be of prognostic significance for ovarian cancer patients. The results of the in vitro analyses confirm the biological rationale for their interplay and identify GPER agonists, such as G1, as a potential therapeutic approach for future investigations.

scholarly journals G Protein-Coupled Receptor 30 Expression Is Up-Regulated by EGF and TGFα in Estrogen Receptor α-Positive Cancer Cells

2009 ◽  
Vol 23 (11) ◽  
pp. 1815-1826 ◽  
Author(s):  
Adele Vivacqua ◽  
Rosamaria Lappano ◽  
Paola De Marco ◽  
Diego Sisci ◽  
Saveria Aquila ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Cancer Cells ◽  
G Protein ◽  
Estrogen Receptor Α ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
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