scholarly journals Polybrominated Diphenyl Ethers Induce Developmental Neurotoxicity in a Human in Vitro Model: Evidence for Endocrine Disruption

2010 ◽  
Vol 118 (4) ◽  
pp. 572-578 ◽  
Author(s):  
Timm Schreiber ◽  
Kathrin Gassmann ◽  
Christine Götz ◽  
Ulrike Hübenthal ◽  
Michaela Moors ◽  
...  
Keyword(s):  
Endocrine Disruption ◽  
Polybrominated Diphenyl Ethers ◽  
In Vitro Model ◽  
Developmental Neurotoxicity ◽  
Diphenyl Ethers ◽  
Model Evidence ◽  
Vitro Model

495 A new in vitro model for testing developmental neurotoxicity

2003 ◽  
Vol 144 ◽  
pp. s133
Author(s):  
Ellen Fritsche ◽  
Ulrike Hübenthal ◽  
Josef Abel
Keyword(s):  
In Vitro Model ◽  
Developmental Neurotoxicity ◽  
Vitro Model

miRNA profiling as a tool for developmental neurotoxicity pathway analysis in human in vitro model

2013 ◽  
Vol 221 ◽  
pp. S153-S154
Author(s):  
Anna Price ◽  
Marco Fabbri ◽  
Maria Grazia Sacco ◽  
Laura Gribaldo ◽  
David Pamies ◽  
...  
Keyword(s):  
Pathway Analysis ◽  
In Vitro Model ◽  
Developmental Neurotoxicity ◽  
Mirna Profiling ◽  
Vitro Model

An in vitro model for investigation of vitamin A effects on wound healing

2021 ◽  
pp. 1-6
Author(s):  
Hoda Keshmiri Neghab ◽  
Mohammad Hasan Soheilifar ◽  
Gholamreza Esmaeeli Djavid
Keyword(s):  
Wound Healing ◽  
Endothelial Cell ◽  
Vitamin A ◽  
In Vitro Model ◽  
Cellular Proliferation ◽  
Endothelial Cell Migration ◽  
Normal Fibroblast ◽  
Anti Inflammatory ◽  
Vitro Model

Abstract. Wound healing consists of a series of highly orderly overlapping processes characterized by hemostasis, inflammation, proliferation, and remodeling. Prolongation or interruption in each phase can lead to delayed wound healing or a non-healing chronic wound. Vitamin A is a crucial nutrient that is most beneficial for the health of the skin. The present study was undertaken to determine the effect of vitamin A on regeneration, angiogenesis, and inflammation characteristics in an in vitro model system during wound healing. For this purpose, mouse skin normal fibroblast (L929), human umbilical vein endothelial cell (HUVEC), and monocyte/macrophage-like cell line (RAW 264.7) were considered to evaluate proliferation, angiogenesis, and anti-inflammatory responses, respectively. Vitamin A (0.1–5 μM) increased cellular proliferation of L929 and HUVEC (p < 0.05). Similarly, it stimulated angiogenesis by promoting endothelial cell migration up to approximately 4 fold and interestingly tube formation up to 8.5 fold (p < 0.01). Furthermore, vitamin A treatment was shown to decrease the level of nitric oxide production in a dose-dependent effect (p < 0.05), exhibiting the anti-inflammatory property of vitamin A in accelerating wound healing. These results may reveal the therapeutic potential of vitamin A in diabetic wound healing by stimulating regeneration, angiogenesis, and anti-inflammation responses.

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