scholarly journals Changes in Urinary Arsenic Methylation Profiles in a 15-Year Interval after Cessation of Arsenic Ingestion in Southwest Taiwan

2009 ◽  
Vol 117 (12) ◽  
pp. 1860-1866 ◽  
Author(s):  
Yung-Kai Huang ◽  
Ya-Li Huang ◽  
Yu-Mei Hsueh ◽  
Jimmy Tse-Jen Wang ◽  
Mo-Hsiung Yang ◽  
...  
Keyword(s):  
Arsenic Methylation ◽  
Urinary Arsenic ◽  
Arsenic Ingestion

Polymorphisms in arsenic metabolism genes, urinary arsenic methylation profile and cancer

2009 ◽  
Vol 20 (9) ◽  
pp. 1653-1661 ◽  
Author(s):  
Chi-Jung Chung ◽  
Yu-Mei Hsueh ◽  
Chyi-Huey Bai ◽  
Yung-Kai Huang ◽  
Ya-Li Huang ◽  
...  
Keyword(s):  
Methylation Profile ◽  
Arsenic Metabolism ◽  
Arsenic Methylation ◽  
Urinary Arsenic

scholarly journals Determinants of arsenic methylation efficiency and urinary arsenic level in pregnant women in Bangladesh

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Shangzhi Gao ◽  
Pi-I Lin ◽  
Golam Mostofa ◽  
Quazi Quamruzzaman ◽  
Mahmudur Rahman ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Energy Intake ◽  
Protein Intake ◽  
Arsenic Concentration ◽  
Arsenic Species ◽  
Exposure Level ◽  
Arsenic Level ◽  
Arsenic Metabolism ◽  
Arsenic Methylation ◽  
Urinary Arsenic

Abstract Background Prenatal inorganic arsenic (iAs) exposure is associated with pregnancy outcomes. Maternal capabilities of arsenic biotransformation and elimination may influence the susceptibility of arsenic toxicity. Therefore, we examined the determinants of arsenic metabolism of pregnant women in Bangladesh who are exposed to high levels of arsenic. Methods In a prospective birth cohort, we followed 1613 pregnant women in Bangladesh and collected urine samples at two prenatal visits: one at 4–16 weeks, and the second at 21–37 weeks of pregnancy. We measured major arsenic species in urine, including iAs (iAs%) and methylated forms. The proportions of each species over the sum of all arsenic species were used as biomarkers of arsenic methylation efficiency. We examined the difference in arsenic methylation using a paired t-test between first and second visits. Using linear regression, we examined determinants of arsenic metabolism, including age, BMI at enrollment, education, financial provider income, arsenic exposure level, and dietary folate and protein intake, adjusted for daily energy intake. Results Comparing visit 2 to visit 1, iAs% decreased 1.1% (p <  0.01), and creatinine-adjusted urinary arsenic level (U-As) increased 21% (95% CI: 15, 26%; p <  0.01). Drinking water arsenic concentration was positively associated with iAs% at both visits. When restricted to participants with higher adjusted urinary arsenic levels (adjusted U-As > 50 μg/g-creatinine) gestational age at measurement was strongly associated with DMA% (β = 0.38, p <  0.01) only at visit 1. Additionally, DMA% was negatively associated with daily protein intake (β = − 0.02, p <  0.01) at visit 1, adjusting for total energy intake and other covariates. Conclusions Our findings indicate that arsenic metabolism and adjusted U-As level increase during pregnancy. We have identified determinants of arsenic methylation efficiency at visit 1.

Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility

2008 ◽  
Vol 46 (3) ◽  
pp. 929-938 ◽  
Author(s):  
Yung-Kai Huang ◽  
Yeong-Shiau Pu ◽  
Chi-Jung Chung ◽  
Horng-Sheng Shiue ◽  
Mo-Hsiung Yang ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Folate Level ◽  
Arsenic Methylation ◽  
Plasma Folate ◽  
Urinary Arsenic

Urinary arsenic methylation profile in children exposed to low arsenic levels through drinking water

2008 ◽  
Vol 90 (5) ◽  
pp. 957-970 ◽  
Author(s):  
Maria M. Meza-Montenegro ◽  
Michael J. Kopplin ◽  
Jefferey L. Burgess ◽  
A. Jay Gandolfi
Keyword(s):  
Drinking Water ◽  
Methylation Profile ◽  
Arsenic Methylation ◽  
Urinary Arsenic

Urinary arsenic methylation and porphyrin profile of C57Bl/6J mice chronically exposed to sodium arsenate

2007 ◽  
Vol 379 (2-3) ◽  
pp. 235-243 ◽  
Author(s):  
Manonmanii Krishnamohan ◽  
Hui-Jie Wu ◽  
Shu-Huei Huang ◽  
Robyn Maddelena ◽  
Paul K.S. Lam ◽  
...  
Keyword(s):  
Sodium Arsenate ◽  
Arsenic Methylation ◽  
Urinary Arsenic

scholarly journals The association between gsto1 polymorphisms and arsenic methylation of prenatal arsenic exposed infants

2018 ◽  
Vol 15 (2) ◽  
pp. 223-230
Author(s):  
Tạ Thị Bình Tạ Thị Bình Tạ Thị Bình ◽  
Trần Phương Thảo ◽  
Nguyễn Khắc Hải ◽  
Nguyễn Huy Hoàng
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Arsenic Exposure ◽  
Nucleotide Polymorphisms ◽  
Glutathione S Transferase ◽  
Negative Effects ◽  
Single Nucleotide ◽  
Arsenic Methylation ◽  
Urinary Arsenic ◽  
The Difference ◽  
High Level

The trace element arsenic naturally presents in the environment. Arsenic is the essential factor to the human body at low level, however it causes environmental pollution and have negative effects to health at high level. Recently, arsenic contamination as well as its effects on public health, especially infants and children is increasingly becoming important and serious issues in worldwide. Glutathione S-transferase omega-1 (GSTO1) is a phase II enzymatic detoxification of xenobiotics in variety of animals including humans; to catalyze the arsenic methylation. The difference of urinary arsenic component in each individual may relate to the genetic polymorphism. To evaluate the variations of single nucleotide polymorphisms of GSTO1, PCR-RFLP technology was ultilized. Single nucleotide polymorphisms (SNPs) genotype of 150 cohort blood samples at GSTO1 Thr->Asn (rs15032), GSTO1 Ala->Val (rs11509439) and GSTO1 Ala->Asp (rs4925) were detected. The association between GSTO1 polymorphisms and prenatal arsenic exposure was evaluated by statistical analysis such as SPSS software version 20, t-test and oneway ANOVA. The results showed that GSTO1 Ala->Asp (rs4925) was statistically associated with MMA/iAs (p = 0.041). Differences between ratio of MMA/iAs and genotypes were checked by Tukey-Kramer method, along with oneway ANOVA showed that Individuals taking the AA genotype had higher MMA/ iAs ratio than individuals carrying the CC genotype, with a statistically significant association (p = 0.044), also clearly higher than the individuals carrying AC genotype, significant at p = 0.046. Therefore, it is possible that individuals carrying the AA genotype in the polymorphism have higher arsenic excretion than individuals with CC and AC genotypes

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