scholarly journals Partitioning of benzene in blood: influence of hemoglobin type in humans and animals.

2002 ◽  
Vol 110 (3) ◽  
pp. 255-261 ◽  
Author(s):  
Mildred J Wiester ◽  
Darrell W Winsett ◽  
Judy H Richards ◽  
Donald L Doerfler ◽  
Daniel L Costa
Keyword(s):  
Hemoglobin Type

scholarly journals Electroretinogram Findings in Early-Stage Sickle Cell Retinopathy According to Hemoglobin Type

2017 ◽  
Vol 58 (7) ◽  
pp. 3262 ◽  
Author(s):  
Caroline Bottin ◽  
Julie Racine ◽  
Matthieu P. Robert ◽  
Salomon-Yves Cohen ◽  
Benedicte M. J. Merle ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Early Stage ◽  
Hemoglobin Type

Effect of hemoglobin type on the cardiorespiratory system of sheep

1965 ◽  
Vol 209 (3) ◽  
pp. 593-598 ◽  
Author(s):  
T. J. Dawson ◽  
J. V. Evans
Keyword(s):  
Oxygen Affinity ◽  
The Other ◽  
Domestic Sheep ◽  
Cardiorespiratory System ◽  
Hemoglobin Type ◽  
Lower Oxygen ◽  
Respiratory Systems ◽  
Genetically Determined ◽  
Theoretical Considerations

In domestic sheep there exist two genetically determined types of hemoglobin which have considerably different oxygen affinities. Under most conditions sheep with either of these hemoglobins exist together, apparently sheep with one type being at no gross disadvantage compared to those with the other. Theoretical considerations suggested that the tissues of sheep with the higher oxygen affinity hemoglobin (Hb-A) should be hypoxic relative to those of sheep with the lower oxygen affinity hemoglobin (Hb-B). The data obtained showed that the cardiovascular and respiratory systems of animals with different hemoglobins differed in many respects. It was concluded that the nature of these differences was such that they could be viewed as being due to adjustments by animals with Hb-A to alleviate the potential hypoxia of their tissues relative to the tissues of animals with Hb-B.

scholarly journals Paper Electrophoresis of Abnormal Hemoglobins and Its Clinical Applications

Blood ◽  
1954 ◽  
Vol 9 (9) ◽  
pp. 897-910 ◽  
Author(s):  
ARNO G. MOTULSKY ◽  
MILTON H. PAUL ◽  
E. L. DURRUM
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Fetal Hemoglobin ◽  
Paper Electrophoresis ◽  
Clinical Applications ◽  
Hemoglobin C ◽  
Hemoglobin Type ◽  
Cell Life ◽  
Practical Tool ◽  
Adult Hemoglobin

Abstract 1. Paper electrophoresis of abnormal hemoglobins is a simple and convenient technic for the study of the hereditary hemoglobinopathies. 2. A semiquantitative paper electrophoretic technic is described, which allows rather accurate quantitation of the various hemoglobin components by inspection alone. 3. For exact results, the more elaborate technics of elution or photoelectric scanning may be employed. The accuracy of these quantitative technics is illustrated by artificial mixture experiments. 4. The clinical applications of the method in the study of sickle cell disease and hemoglobin C abnormalities are discussed. Apart from the more common hemoglobin abnormalities (such as sickle cell trait, sickle cell anemia, C trait, sickle cell-hemoglobin C disease), a patient with 100 per cent hemoglobin C (homozygous hemoglobin C disease) and a Negro patient with sickle cell-thalassemia disease were discovered. Normal adult hemoglobin (hemoglobin A) was found in all other hereditary and acquired anemias studied. Slightly increased amounts of fetal hemoglobin were detected in cases of hereditary nonspherocytic hemolytic disease and aregenerative anemia. 5. This technic may be used for red cell life span determinations by serially following the disappearance of a certain hemoglobin type transfused into a patient with a different hemoglobin variety. Further applications of the technic are suggested. 6. The combination of the technics of paper electrophoresis and alkali denaturation offer an adequate, simple, and practical tool for diagnosis and investigation of hereditary hemoglobinopathies. 7. Identical apparatus and buffer may be used for serum protein electrophoresis.

Molecular identification of hereditary persistence of fetal hemoglobin type 2 (HPFH type 2) in patients from Brazil

1995 ◽  
Vol 70 (3) ◽  
pp. 159-161
Author(s):  
M. S. Gon�alves ◽  
S. Fahel ◽  
M. S. Figueiredo ◽  
E. J. Kimura ◽  
F. Nechtman ◽  
...  
Keyword(s):  
Molecular Identification ◽  
Fetal Hemoglobin ◽  
Hemoglobin Type ◽  
Hereditary Persistence

Mental Health Symptoms, Quality of Life and Barriers to Accessing Health Care in Sickle Cell Disease

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 337-337
Author(s):  
Marsha J Treadwell ◽  
Fernando Barreda ◽  
Kimberly Major ◽  
Valentino Walker ◽  
Wanda Payton ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Health Care ◽  
African American ◽  
Pediatric Patients ◽  
Cell Disease ◽  
Mental Health Symptoms ◽  
Health Symptoms ◽  
Hemoglobin Type

Abstract Abstract 337 Background: Individuals with sickle cell disease (SCD) face a number of barriers as they attempt to access timely and appropriate health care. We previously reported that adult and pediatric patients with SCD differed on some barriers reported, with adults citing more barriers related to insurance and provider knowledge and attitudes. Patients' emotional status, including worry, frustration and anger, were also reported barriers to accessing health care. However, there has been limited research formally assessing mental health symptoms as potential barriers to accessing health care in SCD. Objective: To investigate the relation between mental health symptoms, quality of life and reported barriers to accessing healthcare. We hypothesized that 1) mental health symptoms would be predictive of reported barriers, for adults with SCD compared with children, and 2) quality of life would be inversely related to the number of reported barriers, for adults and children. Methods: 112 patients with SCD were enrolled in a cross sectional study. Pediatric patients and their parents, and adults with SCD completed screening measures of depression (Patient Health Questionnaire-9 or Children's Depression Inventory) and anxiety (Generalized Anxiety Disorder- 7 or Multidimensional Anxiety Scale for Children-10) and were categorized with no, mild, moderate or severe symptoms. They also completed quality of life measures (SF 36v2® or PedsQL®) and a validated checklist of barriers to accessing healthcare for SCD. Results: Participants were 35 children (M age 9.5, 1– 17 years) and their parents, and 77 adults (M age 31.2, 18 – 68 years); 53% female; 75% African American; 71% diagnosed with Hgb SS. Sixty one percent of adults reported moderate to severe depressive symptoms, compared with 4% of children (p <.001). Thirty-six percent of adults reported moderate to severe symptoms of anxiety, compared with 12% of children (p <.05). Adults reported significantly worse quality of life in the Physical (M =53.0, SD =23.7) and Mental Health (M =49.4, SD =23.2) domains compared with children (Physical M =65.6, SD =21.4, p <.05 and Mental Health M =66.0, SD =17.9, p <.01). In regression analyses, we found that, with gender and hemoglobin type controlled for, depression was predictive of number of barriers faced for adult (R2 =.27, β = 3.57 ±.88, n = 74) but not pediatric patients (R2 =.26, β = 5.68 ± 2.54, n = 26). Anxiety was predictive of number of barriers faced for adults (R2 =.28, β = 3.99 ±.94, n = 75) but not pediatric patients (R2 =.13, β = 2.13 ± 1.96, n = 26). Greater number of barriers faced was predictive of worse quality of life in the Mental Health domain for both adults and pediatrics, controlling for gender and hemoglobin type (R2 =.19, β = −.98 ±.26, n = 73 for adults and R2 =.28, β = −1.06 ±.36, n = 33 for pediatrics). In the Physical domain, greater number of barriers faced was predictive of worse quality of life for adults but not pediatrics, controlling for gender and hemoglobin type (R2 =.18, β = −.97 ±.26, n = 73 for adults and R2 =.15, β = −1.03 ±.46, n = 33 for pediatrics). Conclusion: Adults with SCD reported a higher prevalence of moderate to severe symptoms of depression and anxiety, compared with children with SCD and the general African American population. Mental health symptoms were predictive of difficulties with accessing health care for adult more so than pediatric patients. There is an urgent need to address barriers to health care for patients with SCD; to prevent morbidity in pediatrics that may contribute to impaired quality of life in adulthood; and to improve mental health services available to adults in particular. Disclosures: No relevant conflicts of interest to declare.

scholarly journals DEVELOPMENTAL CHANGES OF ERYTHROPOIESIS IN CULTURED CHICK BLASTODERMS

1971 ◽  
Vol 51 (2) ◽  
pp. 440-451 ◽  
Author(s):  
Helen K. Hagopian ◽  
Vernon M. Ingram
Keyword(s):  
Cell Population ◽  
Developmental Changes ◽  
Erythroid Cell ◽  
Synthetase Activity ◽  
Red Cell ◽  
Cell Type ◽  
Cell Cycle Time ◽  
Population Kinetics ◽  
Area Vasculosa ◽  
Hemoglobin Type

The erythropoietic area of very early chick embryos was cultured as a tissue for up to nine days to study the changes in red cell type and hemoglobin type, the cell cycle time, the cell population kinetics, and the DNA synthetase activity of these cells. It was found that the area vasculosa without the participation of the embryo proper contained the information and the timing mechanism required to produce not only the early primitive erythroid cell population, but also in due course, the later definitive cell type, each with its appropriate hemoglobin types. Also the precursors of the definitive cell type are active in DNA synthesis and therefore are probably in cycle very early in the culture period.

scholarly journals Hemoglobin Type Analysis of Ryukyu and Tokara Native Horses

1991 ◽  
Vol 62 (4) ◽  
pp. 351-353
Author(s):  
Yukinori EGUCHI ◽  
Yasutsugu NAKASHIMA ◽  
Minoru OSHIRO ◽  
Masao SUGAMATA ◽  
Hiroshi TAKEI ◽  
...  
Keyword(s):  
Type Analysis ◽  
Hemoglobin Type
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