scholarly journals Effect of electromagnetic field exposure on chemically induced differentiation of friend erythroleukemia cells.

2000 ◽  
Vol 108 (10) ◽  
pp. 967-972 ◽  
Author(s):  
G Chen ◽  
B L Upham ◽  
W Sun ◽  
C C Chang ◽  
E J Rothwell ◽  
...  
Keyword(s):  
Electromagnetic Field ◽  
Induced Differentiation ◽  
Field Exposure ◽  
Erythroleukemia Cells ◽  
Chemically Induced ◽  
Friend Erythroleukemia Cells

scholarly journals NF-E2p18/mafK is required in DMSO-induced differentiation of Friend erythroleukemia cells by enhancing NF-E2 activity

Leukemia ◽  
1997 ◽  
Vol 11 (2) ◽  
pp. 273-280 ◽  
Author(s):  
C Francastel ◽  
V Poindessous-Jazat ◽  
Y Augery-Bourget ◽  
J Robert-Lézénès
Keyword(s):  
Induced Differentiation ◽  
Erythroleukemia Cells ◽  
Friend Erythroleukemia Cells

scholarly journals Hypomethylation of DNA during differentiation of friend erythroleukemia cells

1980 ◽  
Vol 86 (2) ◽  
pp. 366-370 ◽  
Author(s):  
JK Christman ◽  
N Weich ◽  
B Schoenbrun ◽  
N Schneiderman ◽  
G Acs
Keyword(s):  
Dimethyl Sulfoxide ◽  
Mammalian Cells ◽  
Dna Methyltransferases ◽  
Methyl Groups ◽  
Close Link ◽  
Erythroleukemia Cells ◽  
Chemically Induced ◽  
Methyl Cytosine ◽  
Friend Erythroleukemia Cells

DNA from mammalian cells has been shown to contain significant amounts of 5-methyl cytosine resulting from enzymatic transfer of methyl groups from s-adenosylmethionine to cytosine residues in the DNA polymer. The function of this modification is not known. We have found that DNA synthesized during chemically induced differentiation of friend erythroleukemia cells is hypomethylated, as measured by its ability to accept methyl groups transferred by homologous DNA methyltransferases in vitro. The extent of hypomethylation detected by this sensitive method is small, a decrease of less than 1.6 percent in 5-methylcytosine content. Hypomethylated DNA can be isolated from friend erythroleukemia cells grown in the presence of dimethyl sulfoxide, butyrate, hexamethylene-bis- acetamide, pentamethylene-bis acetamide, and ethionine. However, hypomethylated DNA is found only under conditions where differentiation is actually induced. DNA isolated from cells of a dimethyl sulfoxide- resistant subclone grown in the presence of that agent is not hypomethylated, although DNA of these cells becomes hypomethylated after growth in the presence of inducers that can trigger their differentiation. We also find that the DNA of friend erythroleukemia cells does not become hypomethylated when the cells are exposed to inducing agents in the presence of substances that inhibit differentiation. These results suggest a close link between genome modification by methylation and differentiation of friend erythroleukemia cells.

Protein Kinase Cα Is an Effector of Hexamethylene Bisacetamide-Induced Differentiation of Friend Erythroleukemia Cells

1999 ◽  
Vol 246 (2) ◽  
pp. 348-354 ◽  
Author(s):  
Conrad M. Mallia ◽  
Victoria Aguirre ◽  
Eric McGary ◽  
Yan Tang ◽  
Aline B. Scandurro ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Induced Differentiation ◽  
Hexamethylene Bisacetamide ◽  
Erythroleukemia Cells ◽  
Protein Kinase Cα ◽  
Friend Erythroleukemia Cells
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