Inherited Thrombocytopenia and Thrombasthenia in Egyptian Children and Adolescents

2019 ◽  
Vol 36 (1-2) ◽  
pp. 171-180
Author(s):  
Iman A. Ragab ◽  
Mohsen S. Elalfy ◽  
Azza A. G. Tantawy ◽  
Mohammad T. Hamza ◽  
Marwa M. Reda ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Egyptian Children ◽  
Inherited Thrombocytopenia

scholarly journals Sleep quality and anxiety symptoms in Egyptian children and adolescents during COVID-19 pandemic lockdown

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Amira Sayed El Refay ◽  
Shaimaa A. Hashem ◽  
Hend H. Mostafa ◽  
Iman H. Kamel ◽  
Lobna S. Sherif
Keyword(s):  
Mental Health ◽  
Children And Adolescents ◽  
Low Income ◽  
Sleep Disturbances ◽  
Family Income ◽  
Anxiety Symptoms ◽  
Snowball Sampling ◽  
Contributing Factors ◽  
Online Questionnaire ◽  
Egyptian Children

Abstract Background Coronavirus Disease Pandemic 2019 has a pervasive effect on all health aspects include psychological and mental health. This study aimed to assess the hidden stressful impact of COVID-19 pandemic on Egyptian children and adolescents’ lifestyles 2 months after lockdown in Egypt by detecting symptoms of anxiety and sleep disorders. Online questionnaire was used by snowball sampling approach 2 months after lockdown targeting children and adolescents. Results The overall mean Sleep Disturbance Scale for Children score (SDSC) in participated groups was 44.6 ± 11.72. Of 765 participants 502 (65.6%) showed the symptoms suggestive of sleep disorder. Disorders of initiating and maintaining sleep were the most common among participants as 168 (33.4%) of them were suffering from it while 79 (15.7%) children were suffering from excessive somnolence. Linear stepwise regression revealed that anxiety score, understanding safety measures, and following strict quarantine measures significantly predicted SDSC (p = 0.001, 0.009, 0.046). Significant positive correlations were found between SDSC and extra screen usage, understanding safety and quarantine measures, anxiety signs, and change in child lifestyle with (p = 0.029, 0.010, 0.001 and 0.001) sequentially. Significant positive correlation was found between family income affection, SDSC, and anxiety with p value (00.001, 00.4). Conclusion Child deprived of his or her normal lifestyle is vulnerable to develop anxiety symptoms and sleep disturbances. Low income, extra screen time, and restricted quarantine measures are all contributing factors that influence children and adolescent’s mental health.

Association of ficolin-2 gene polymorphisms and susceptibility to systemic lupus erythematosus in Egyptian children and adolescents: a multicenter study

Lupus ◽  
2019 ◽  
Vol 28 (8) ◽  
pp. 995-1002 ◽  
Author(s):  
M A Elkoumi ◽  
A A Emam ◽  
M A N Allah ◽  
A H Sherif ◽  
N M Abdelaal ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Confidence Interval ◽  
Children And Adolescents ◽  
Multicenter Study ◽  
Odds Ratio ◽  
Gene Polymorphisms ◽  
Enzyme Linked Immunosorbent Assay ◽  
Promoter Polymorphisms ◽  
Intron 1 ◽  
Egyptian Children

Background Pediatric-onset SLE (pSLE) is a multisystem autoimmune disease. Recently, the ficolin-2 (FCN2) gene has emerged as a potential candidate gene for susceptibility to SLE. Objectives The objective of this study was to evaluate the association of the FCN2 gene polymorphisms at positions −986 (G/A), −602 (G/A), −4 (A/G) and SNP C/T (rs3124954) located in intron 1, with susceptibility to pSLE in Egyptian children and adolescents. Methods This was a multicenter study of 280 patients diagnosed with pSLE, and 280 well-matched healthy controls. The FCN2 promoter polymorphisms at –986 G/A (rs3124952), −602 G/A (rs3124953), −4 A/G (rs17514136) and SNP C/T (rs3124954) located in intron 1 were genotyped by polymerase chain reaction, while serum ficolin-2 levels were assessed using enzyme-linked immunosorbent assay. Results The frequencies of the FCN2 GG genotype and G allele at −986 and −602 positions were significantly more represented in patients with pSLE than in controls ( p < 0.001). Conversely, the FCN2 AA genotype and A allele at position −4 were more common in patients than in controls ( p < 0.001). Moreover, patients carrying the FCN2 GG genotype in −986 position were more likely to develop lupus nephritis (odds ratio: 2.6 (95% confidence interval: 1.4–4.78); p = 0.006). The FCN2 AA genotype at position −4 was also identified as a possible risk factor for lupus nephritis (odds ratio: 3.12 (95% confidence interval: 1.25–7.84); p = 0.024). Conclusion The FCN2 promoter polymorphisms may contribute to susceptibility to pSLE in Egyptian children and adolescents. Moreover, the FCN2 GG genotype at position −986 and AA genotype at position −4 were associated with low serum ficolin-2 levels and may constitute risk factors for lupus nephritis in pSLE.

Assessment of health-related quality of life in Egyptian children and adolescents with congenital adrenal hyperplasia

2020 ◽  
Vol 33 (2) ◽  
pp. 295-304
Author(s):  
Noha Musa ◽  
Noha Asem ◽  
Shaza Basyony ◽  
Lubna Fawaz
Keyword(s):  
Quality Of Life ◽  
Congenital Adrenal Hyperplasia ◽  
Children And Adolescents ◽  
Hospital Admissions ◽  
Hormonal Control ◽  
Physical Domain ◽  
Adrenal Hyperplasia ◽  
Egyptian Children ◽  
Health Related

AbstractBackgroundCongenital adrenal hyperplasia (CAH) is a chronic disorder causing adrenal insufficiency and hyperandrogenism affecting the quality of life (QOL). The objective of the study was to assess the health-related QOL (HRQOL) in Egyptian children and adolescents with CAH and to identify factors affecting it.MethodsThis cross-sectional study included 200 CAH patients (with 21-hydroxylase deficiency [21-OHD]) who were assessed according to their age, sex, clinical phenotype, timing of genitoplasty, hospital admissions within the last year, compliance to treatment, regularity of follow-up, presence of complications and hormonal control. HRQOL was assessed using the World Health Organization (WHO)QOL-BREF questionnaire with four domains analyzed independently including physical, psychological, social and environmental domains, with higher scores indicating better QOL.ResultsThe study included 140 females and 60 males with a mean age of 6.6 ± 4.5 years, and 88% were salt-wasting (SW). Older patients had significantly lower QOL scores (r = − 0.151, p = 0.033). The physical domain correlated significantly with the degree of virilization (r = − 0.491, p = 0.001) and frequency of hospitalization (r = − 0.495, p < 0.001). The psychological domain was affected by age (r = − 0.157, p = 0.026) and timing of genitoplasty (r = − 0.326, p = 0.001), while the social domain was affected by age (r = −0.277, p < 0.005) and pubertal stage (r = − 0.195, p = 0.006). Females had lower scores at the psychological domain (p < 0.001), whereas males had lower scores at the physical domain (p = 0.003). Salt-losing patients had lower scores at the physical domain (p = 0.001). Patients with good hormonal control had higher scores at the physical domain (p = 0.03). Genitoplasty affected both psychological and social domains (p = 0.003 and 0.01, respectively). Patients with hypertension and hirsutism had lower QOL scores (p < 0.05).ConclusionsHRQOL was relatively more affected in CAH patients with older age, poor hormonal control, high frequency of hospital admissions and those who developed complications.

Quality of Life in Egyptian Children and Adolescents with Sickle Cell Anemia

2017 ◽  
Vol 34 (1-2) ◽  
pp. 109-118
Author(s):  
Mohamed Abdel-Mohsen Ellabody ◽  
Hisham Ahmed Ramy ◽  
Naglaa Fathy Mahmoud
Keyword(s):  
Quality Of Life ◽  
Children And Adolescents ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Egyptian Children

scholarly journals Cutaneous manifestations among Egyptian children and adolescents with type 1 diabetes

2016 ◽  
Vol 64 (1) ◽  
pp. 44-49 ◽  
Author(s):  
Randa M. Youssef ◽  
Amany Ibrahim ◽  
Iman M. Amin ◽  
Hend M. Soliman ◽  
Amany Ali
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Cutaneous Manifestations ◽  
Egyptian Children

scholarly journals Prevalence and pattern of dyslipidemia in an Egyptian children and adolescents with type 1 diabetes

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Hend Soliman ◽  
Amany Ibrahim
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Children And Adolescents ◽  
Glycosylated Hemoglobin ◽  
Laboratory Data ◽  
Density Lipoprotein ◽  
Diabetes Duration ◽  
Egyptian Children ◽  
Diabetic Children

Abstract Background Hyperglycemia and dyslipidemia are commonly found metabolic abnormalities in diabetic children and adolescents and both increase the risk of cardiovascular disease. This study aimed to assess the prevalence and the pattern of dyslipidemia in Egyptian children and adolescents with type 1 diabetes (T1DM) and determine its relation with the glycemic control. Results This retrospective study included 806 children and adolescents with T1DM; 358 (44.42%) males and 448 (55.58%) females. Their mean age was 11.71 ± 3.6 years. Clinical and laboratory data were recruited from patients’ files. Laboratory data include the most recent fasting lipid profile (triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL)), and the mean glycosylated hemoglobin (HbA1c) levels over the preceding year presented in percentage were calculated. Dyslipidemia in children and adolescents with T1DM represented 70.47% (568 patients). No statistically significant differences were detected between patients with and without dyslipidemia. As regards the pattern of dyslipidemia, high LDL and low HDL were the most frequent abnormalities in the study group; 62.16%, 60.21%, respectively. Patients with poor glycemic control (HbA1c > 7.5%) represent 73.45% and they were significantly older, with longer diabetes duration and higher TC, TG, and LDL compared to patients with good glycemic control. Significant positive correlations were found between HbA1c, TG, TC, and LDL with the age and diabetes duration. Conclusion We detected high prevalence of dyslipidemia in children and adolescents with T1DM. Therefore, dyslipidemia should be screened for in earlier ages in Egyptian children and adolescents suffering from T1DM. Programs directed to the prevention of dyslipidemia should be conducted, particularly for this group, in order to prevent/delay cardiovascular complications related to dyslipidemia. Also, parents should receive proper education targeting the prevention, control, and care of their diabetic children with dyslipidemia.

Dyslipidemia in Egyptian children and adolescents with type 1 diabetes mellitus.

2017 ◽  
Vol 34 (2) ◽  
pp. 104-107
Author(s):  
Mohamed M. El Bakry ◽  
Amira I. Mansour ◽  
Marwa E. Ahmed ◽  
Hamada E. Sptan
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Egyptian Children
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