scholarly journals EFFECT OF QUERCETIN ADMINISTRATION ON LIPID PROFILE, INFLAMMATORY AND OXIDATIVE STRESS MARKERS IN A RAT MODEL OF PROPYLTHIOURACIL-INDUCED HYPOTHYROIDISM

2018 ◽  
Vol 47 (2) ◽  
pp. 387-402
Author(s):  
Fatma M. Lebda ◽  
Sahar M. El Agaty ◽  
Noha N. Lasheen ◽  
Haliema A. El Sherif
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Rat Model ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
And Oxidative Stress

scholarly journals Effects of Lycium barbarum L. Polysaccharides on Inflammation and Oxidative Stress Markers in a Pressure Overload-Induced Heart Failure Rat Model

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 466 ◽  
Author(s):  
Cristina Pop ◽  
Cristian Berce ◽  
Steliana Ghibu ◽  
Iuliu Scurtu ◽  
Olga Sorițău ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Body Weight ◽  
Rat Model ◽  
Pressure Overload ◽  
Oxidative Stress Markers ◽  
Lycium Barbarum ◽  
Stress Markers ◽  
Anti Inflammatory ◽  
And Oxidative Stress

Despite recent advances in disease management and prevention, heart failure (HF) prevalence is still high. Hypertension, inflammation and oxidative stress are being investigated as important causative processes in HF. L. barbarum L. polysaccharides (LBPs) are widely used for their anti-inflammatory and antioxidant properties. Thus, the aim of the present study was to evaluate the effects of LBPs on inflammation and oxidative stress markers in a pressure overload-induced HF rat model, surgically induced by abdominal aorta banding in Wistar rats (AAB) (n = 28). Also, control rats (n = 10) were subjected to a sham operation. After echocardiographic confirmation of HF (week 24), AAB rats were divided into three groups: rats treated with LBPs for 12 weeks: 100 mg/kg body weight /day (AAB_100, n = 9), 200 mg/kg body weight /day (AAB_200, n = 7) and no-treatment group (control AAB, n = 12). After 12 weeks of treatment with LBPs, the decline of cardiac function was prevented compared to the control AAB rats. Treatment with 200 mg/kg body weight /day LBPs significantly reduced the inflammation as seen by cytokine levels (IL-6 and TNF-α) and the plasma lipid peroxidation, as seen by malondialdehyde levels. These results suggest that LBPs present anti-inflammatory and antioxidant effects with utility in a HF animal model and encourage further investigation of the cardioprotective effects of these polysaccharides.

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