التلوث الكيميائي للمياه وعلاقته بالإصابة بمرض الفشل الكلوي المزمن في محافظات غزة : دراسة في الجغرافية الطبية = Chemical Pollution of Water and Its Relationship with the Chronic Kidney Failure Disease : A Study in the Medical Geography

Chronic kidney disease is a major global public health problem. The peptide hormones adropin and spexin modulate many physiological functions such as energy balance and glucose, lipid and protein metabolism. However, it is unclear whether these peptides may exert effects on renal damage, tissue remodeling, and inflammatory conditions. In view of the limited information, we aimed to investigate the effect of adropin and spexin on matrix metalloproteinase and inflammatory response genes a rat model of adenine-induced chronic kidney failure. Chronic kidney failure was induced in rats by administering adenine hemisulfate. Renal function was determined in an autoanalyzer. Histopathological modifications were assessed by H&E staining. mRNA expression levels of ALOX 15, COX 1, COX 2, IL-1β, IL-10, IL-17A, IL-18 IL-21, IL-33, KIM-1, MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, NGAL, TGFβ1, TIMP-1, and TNFα in kidney tissue were measured by qPCR. Our results showed an increase of 24-h urine volume, serum creatinine, BUN, and urine protein levels in group with adenine-induced CKF. Adropin and spexin treatments decreased urine protein and 24-h urine volume. Renal damage, TIMP-1, IL-33, and MMP-2 increased after CKF induction, while COX 1, MMP-9, and MMP-13 levels were significantly reduced. Furthermore, KIM-1, TIMP-1, IL-33, and MMP-2 were downregulated by spexin treatment. Renal damage, NGAL, TIMP-1 IL-17A, IL-33, MMP-2, and MMP-3 decreased after adropin treatment, while MMP-13 levels were upregulated. Treatment with adropin+spexin decreased KIM-1, NGAL, TIMP-1, IL-1β, IL-17A, IL-18, IL-33, ALOX 15, COX 1, COX 2, TGFβ1, TNFα, MMP-2, MMP-3, and MMP-7, but increased MMP-13 levels. Our findings revealed that inflammatory response and MMP genes were modulated by adropin and spexin. These peptides may have protective effects on inflammation and chronic kidney damage progression.

Download Full-text

Complications related to dental extractions in patients with chronic kidney failure undergoing hemodialysis: a pilot study

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2021.08.004 ◽

2021 ◽

Author(s):

Natália Silva Andrade ◽

Rubens Caliento ◽

Dmitry Sarmento ◽

Marília Figueiredo ◽

Karem Lopez Ortega ◽

...

Keyword(s):

Pilot Study ◽

Kidney Failure ◽

Chronic Kidney Failure

Download Full-text

Delayed nephrologist referral and inadequate vascular access in patients with advanced chronic kidney failure

Journal of Clinical Epidemiology ◽

10.1016/s0895-4356(02)00415-8 ◽

2002 ◽

Vol 55 (7) ◽

pp. 711-716 ◽

Cited By ~ 100

Author(s):

Jerry Avorn ◽

Wolfgang C Winkelmayer ◽

Rhonda L Bohn ◽

Raisa Levin ◽

Robert J Glynn ◽

...

Keyword(s):

Vascular Access ◽

Kidney Failure ◽

Chronic Kidney Failure

Download Full-text